Open Access Open Access  Restricted Access Access granted  Restricted Access Subscription or Fee Access

Vol 10, No 4 (2012)

Articles
How Barbara McClintock discovered transposable elements in maize
- -.
Abstract
The paper describes the early part of Barbara McClintock`s work on DNA transposons in maize, in which she discovered the Ac-Ds family of mobile "controlling elements". An account is first given of the cytology of the system that was used to generate intact chromosomes having "sticky" (broken) ends. Cytogenetical aspects of the chromatid and chromosome breakage-fusion-bridge cycles, deriving from breakage, are then described, which leads on to the way in which variegation in phenotypes of the maize kernels could be "read" in terms of chromosome breakage. The "genetic earthquake" event of 1944, triggered by introducing broken chromosomes into a zygote from both parents, lead to the discovery of Ds and Ac. Finding mobility of Ds from one chromosomal location to another was pure serendipity: the transposition showed itself while experiments were being undertaken to accurately map Ds. A similar chance observation revealed transposition of Ac as well, and then the relationship between the two elements was elucidated in terms of their autonomous and non-autonomous nature.
Ecological genetics. 2012;10(4):3-13
views
CRISIS OF THE TRADITIONAL VARIABILITY CONCEPT: ON THE WAY TO A NEW PARADIGM
Tikhodeyev O.N.
Abstract
The traditional concept of variability meets a lot of contradictions. These contradictions could be successfully overcome, when such variability aspects as a molecular nature of varieties, their heritability, and the factors directly determining organism phenotype, are clearly distinguished. The partition between hereditary and non-hereditary variability also needs correction since multiple intermediate phenomena are known. A more detailed classification is suggested, which reflects three autonomous aspects of heritability. This approach could be used as a basis for a new paradigm in the notion of variability.
Ecological genetics. 2012;10(4):56-65
views
Population epigenetics, ecotoxicology and human diseases
Patkin E.L., Sofronov H.A.
Abstract
The review critically examines the current state of population epigenetics. Possible mechanisms of intergenerational inheritance of epigenetic and epigenomic modifications as a condition of population epigenetics reality are examined. Special attention is paid to the role of external factors, including diet and various chemical compounds as modulators of the epigenome, and the possible inheritance of epigenetic variability characteristics under the influence of such environmental factors. The role of epigenetic mechanisms in the etiology and susceptibility to complex human diseases is considered.
Ecological genetics. 2012;10(4):14-28
views
ANALYSIS OF ASSOCIATION OF LIPID METABOLISM GENES POLYMORPHISM WITH BMI, WAIST CIRCUMFERENCE AND BLOOD LIPIDOGRAM PARAMETERS IN WOMEN
Tarkovskaia I.V., Glotov O.S., Ditkina E.Y., Vashukova E.S., Glotov A.S., Kurilov R.V., Pugacheva I.V., Belonog O.L., Makhrova I.A., Aseev M.V., Ivashchenko T.E., Baranov V.S.
Abstract
Using the PCR-RFLP method we have studied polymorphism of 36 genes involved in lipid metabolism in 212 women, residents of the North-West Region of Russia (St. Petersburg), aged 18 to 77. We found an association of polymorphism in several candidate genes with body mass index, waist circumference, total cholesterol level, low density lipoprotein cholesterol level and very low density lipoprotein cholesterol level. We propose a logistic regression model for a primary assessment of these parameters in women based on corresponding genetic markers tests.
Ecological genetics. 2012;10(4):66-76
views
A study of genetic markers of human height
Glotov A.S., Vashukova E.S., Glotov O.S., Kurilov R.V., Tarkovskaia I.V., Ditkina E.Y., Pugacheva I.V., Belonog O.L., Makhrova I.A., Pakin V.S., Aseev M.V., Ivashchenko T.E.
Abstract
A population study of polymorphisms of EFEMP1, ZBTB38, HHIP, LCORL, ADAMTSL3, CDH13, JAZF1, IGF1R, GHSR, CABLES1, IFNG, VDR3, and IGFBP3 genes, which possibly influence human height, was carried out using PCR-RFLP. Population frequencies of alleles and genotypes for these genes were established. A correlation between the rs572169 variant of GSHR gene and male height was found . We suggest a model for prediction of human height on the basis of logistic regression method. The obtained data indicate a possibility to assess human height on the basis of genetic markers.
Ecological genetics. 2012;10(4):77-84
views
Developmental genetics and symbiotic potential of cyanobacteria
Khudyakov I.Y.
Abstract
Many cyanobacteria can differentiate specialized cells – heterocysts that fix nitrogen aerobically, akinetes able to survive under unfavorable conditions, and hormogonia providing a means of dispersal. Of great importance for evolution of the biosphere was the ability of cyanobacteria to establish symbioses with eukaryotic organisms that was a prerequisite for the emergence of chloroplasts. This review describes the genes and regulatory systems that control differentiation of specialized cells and the ability of cyanobacteria to establish symbiotic associations with a variety of hosts.
Ecological genetics. 2012;10(4):29-39
views
ANALYSIS OF INTERACTION OF PEA (Pisum sativum L.) SYMBIOTIC GENES Sym33 AND Sym42 WHOSE MUTATIONS RESULT IN ABNORMALITES DURING INFECTION THREAD DEVELOPMENT
Tsyganov V.E., Tsyganova A.V., Voroshilova V.A., Borisov A.U., Tikhonovich I.A.
Abstract
Using pea single mutant lines SGEFix–-2 (sym33) and RisFixV (sym42), which are characterized by different abnormalities during symbiotic nodule development, including thickening of infection threads’ walls, a double mutant RBT4 line, carrying a pair of symbiotic genes sym33 and sym42 was constructed. The epistasis of the mutant allele sym33 over the mutant allele sym42 with respect to the histological and ultrastructural organisation of nodules was shown. Thus, it was demonstrated that Sym33 gene functions earlier in symbiotic nodule development than Sym42 gene.
Ecological genetics. 2012;10(4):50-55
views
Genotoxicity evaluation of drinking water and rates of population morbidity in North Kazakhstan oblast
Larikova N.V., Baboshkina S.V., Likhodumova I.N., Beletskaya N.P., Puzanov A.V., Kirillov V.V., Gorbachev I.V.
Abstract
The genotoxicity assay of drinking water in regional centers of North Kazakhstan oblast is carried out by a cytogenetic ana-telophase method using barley root tips. It is shown that drinking water of North Kazakhstan oblast is able to cause cytogenetic damages. A direct correlation between genotoxic properties of drinking water and the rates of congenital abnormalities, malignant neoplasms (by one of the most common localization in the oblast – a stomach cancer), gastric and duodenal ulcers among the population are revealed.
Ecological genetics. 2012;10(4):40-49
views

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies