Influence of certain factors on adherence to treatment in glaucoma patients in clinical practice
- Authors: Malyshev A.V.1,2, Apostolova A.S.3, Sergienko A.A.2,4, Teshev A.F.2,5, Karapetov G.Y.1,2, Ashhamahova M.K.2,5, Midaev U.I.2,5
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Affiliations:
- Professor S.V. Ochapovsky Regional Clinical Hospital No. 1
- Maykop State Technological University
- Vision Care Clinic “3Z”
- Children’s Regional Clinical Hospital, Krasnodar
- Adygean Republican Clinical Hospital
- Issue: Vol 16, No 2 (2023)
- Pages: 39-48
- Section: Original researches
- Submitted: 11.01.2023
- Accepted: 02.06.2023
- Published: 14.07.2023
- URL: https://journals.eco-vector.com/ov/article/view/121356
- DOI: https://doi.org/10.17816/OV121356
- ID: 121356
Cite item
Abstract
BACKGROUND: Up to 80% of patients do not comply with the treatment regimen, and this leads to the progression of the disease.
AIM: The aim of this study is the analysis of adherence to treatment based on a questionnaire survey of glaucoma patients.
MATERIALS AND METHODS: 139 patients with glaucoma were questioned. The mean age was 67.19 ± 0.84 years, 63.3% were women, 36.7% were men. 73.4% were city residents, 26.6% — village residents. 26% were diagnosed less than a year before, 34.5% — 1–5 years before, 39.5% — 5 years or more before. 47.5% received only medical therapy, the rest had a history of surgery as well. Statistical processing of the obtained results was carried out using the standard statistical analysis software package SPSS Statistics 16.0. The parameters with a normal distribution were presented as M ± m, where M is the mean value, m is the standard error of the mean.
RESULTS: On average, patients received 2.1 ± 0.08 molecules in 1.64 ± 0.06 vials. 48% of patients did not observe the frequency of visits to the ophthalmologist. Violation of adherence was present in 40.5% of cases, the main reason was forgetfulness (51%), 24.5% did not buy the medication on time, discomfort on instillation was reported in 7% of cases, systemic side effects — in 3.5%, other reasons — in 14%. Adherence does not depend on the duration of glaucoma, the number of vials, the place of residence. Contraindications to the prescription of β-blockers were present in 30% of cases.
CONCLUSIONS: The study has confirmed that nearly half of patients are non-adherent to treatment due to forgetfulness.
Full Text
About the authors
Alexey V. Malyshev
Professor S.V. Ochapovsky Regional Clinical Hospital No. 1; Maykop State Technological University
Email: mavr189@narod.ru
ORCID iD: 0000-0002-1448-9690
MD, Dr. Sci. (Med.), head of the ophthalmology Department of Scientific Research Institution; chief ophthalmologist of the Ministry of Health of the Krasnodar Territory; head of the ophthalmology Department; professor of the Ophthalmology Department; corresponding member of RANH
Russian Federation, Krasnodar; Maikop, Republic of AdygeaAnastasiya S. Apostolova
Vision Care Clinic “3Z”
Author for correspondence.
Email: apostolovan@mail.ru
ORCID iD: 0009-0006-3177-4342
MD, Cand. Sci. (Med.), ophthalmologist, ophthalmologist of diagnostic Department
Russian Federation, KrasnodarAleksey A. Sergienko
Maykop State Technological University; Children’s Regional Clinical Hospital, Krasnodar
Email: eyesurg@mail.ru
ORCID iD: 0000-0002-0285-4080
MD, Cand. Sci. (Med.), ophthalmologist; assistant professor
Russian Federation, Maikop, Republic of Adygea; KrasnodarAdam F. Teshev
Maykop State Technological University; Adygean Republican Clinical Hospital
Email: adam.teshev@gmail.com
ORCID iD: 0009-0002-2434-7538
ophthalmologist, head of the Ophthalmology Department; assistant; chief ophthalmologist of the Ministry of Health of the Republic of Adygea
Russian Federation, Maikop, Republic of Adygea; Maikop, Republic of AdygeaGarry Y. Karapetov
Professor S.V. Ochapovsky Regional Clinical Hospital No. 1; Maykop State Technological University
Email: garry.karapetov@gmail.com
ORCID iD: 0000-0002-1511-1219
MD, Cand. Sci. (Med.), ophthalmologist; assistant professor
Russian Federation, Krasnodar; Maikop, Republic of AdygeaMarina K. Ashhamahova
Maykop State Technological University; Adygean Republican Clinical Hospital
Email: mashkhamakhova@gmail.ru
ORCID iD: 0009-0000-0838-2013
ophthalmologist; assistant
Russian Federation, Maikop, Republic of Adygea; Maikop, Republic of AdygeaUmar I. Midaev
Maykop State Technological University; Adygean Republican Clinical Hospital
Email: Umarmidaev@mail.ru
ORCID iD: 0009-0006-7813-211X
ophthalmologist; assistant
Russian Federation, Maikop, Republic of Adygea; Maikop, Republic of AdygeaReferences
- Neroev VV, Kiseleva OA, Bessmertny AM. The main results of a multicenter study of epidemiological features of primary open-angle glaucoma in the Russian Federation. Russian Ophthalmological Journal. 2013;(4):4–7. (In Russ.)
- Machekhin VA, Phabrikantov OL. With regard to early detection and medical examination of patients with glaucoma. Practical medicine. 2013;3(1):44–47. (In Russ.)
- Rossetti L, Digiuni M, Giovanni M, et al. Blindness and glaucoma: A multicenter data review from 7 academic eye clinics. PLoSONE. 2015;10(8): e0136632. doi: 10.1371/journal.pone.0136632
- Peters D, Bengtsson B, Heijl A. Lifetime risk of blindness in open-angle glaucoma. Am J Ophthalmol. 2013;156(4):724–730. doi: 10.1016/j.ajo.2013.05.027
- Kalouda P, Keskini C, Anastasopoulos E, Topouzis F. Achievements and limits of current medical therapy of glaucoma. Bettin P, Khaw PT, editors. Glaucoma surgery. 2017;59:1–14. doi: 10.1159/000458482
- Wolfram C, Stahlberg E, Pfeiffer N. Patient-reported nonadherence with glaucoma therapy. J Ocul Pharmacol Ther. 2019;35(4): 223–228. doi: 10.1089/jop.2018.0134
- Olthoff CMG, Schouten JSAG, van de Borne BW, Webers CAB. Noncompliance with ocular hypotensive treatment in patients with glaucoma or ocular hypertension. Ophthalmology. 2005;112(6): 953–961. DOI: 10.1016/ j.ophtha.2004.12.035
- Alekseev VN, Malevannaya OA, Nader Samih El Haj. The reasons of low adherence in primary open-angle glaucoma patients treatment. Ophthalmology Reports. 2010;3(4):37–39. (In Russ.)
- Neroyev VV, Zolotarev AV, Karlova EV, et al. Influence of treatment adherence on the progression of primary open-angle glaucoma in clinical setting. The Russian Annals of Ophthalmology. 2019;135(6):42–51. (In Russ.) doi: 10.17116/oftalma201913506142
- Garudadri C, Senthil S, Khanna RC, et al. Prevalence and risk factors for primary glaucomas in adult urban and rural populations in the Andhra Pradesh Eye Disease Study. Ophthalmology. 2010;117(7):1352–1359. doi: 10.1016/j.ophtha.2009.11.006
- Kiseleva OA, Robustova OV, Bessmertny AM, et al. Rasprostranennost’ pervichnoi glaukomy u predstavitelei raznykh ras i ehtnicheskikh grupp v mire. Ophthalmology in Russia. 2013;10(3):5–8. (In Russ.) doi: 10.18008/1816-5095-2013-3-5-8
- Neroev VV, Kiseleva OA, Bessmertny AM. The main results of a multicenter study of epidemiological features of primary open-angle glaucoma in the Russian Federation. Russian Ophthalmological Journal. 2013;6(3):43–46. (In Russ.)
- Grishchuk AS, Yuryeva TN, Shchuko AG, et al. Assessment of glaucoma morbidity in Irkutsk region. Kazan medical journal. 2013;94(6):885–889. (In Russ.) doi: 10.17816/KMJ1811
- Egorov EA, Astakhova YuS, Ericheva VP, editors. Natsional’noe rukovodstvo po glaukome. Dlya praktikuyushchikh vrachei. Moscow: GEOTAR-Media, 2015. 456 p. (In Russ.)
- Newman-Casey PA, Robin AL, Blachley T, et al. The most common barriers to glaucoma medication adherence: a cross-sectional survey. Ophthalmology. 2015;122(7):1308–1316. doi: 10.1016/j.ophtha.2015.03.026
- Makogon SI, Onishchenko AL, Makogon AS. Treatment adherence in elderly and senile patients with primary open-angle glaucoma. National Journal glaucoma. 2019;18(4):3–13. (In Russ.) doi: 10.25700/NJG.2019.04.01
- Frech S, Kreft D, Guthoff RF, Doblhammer G. Pharmacoepidemiological assessment of adherence and influencing co-factors among primary open-angle glaucoma patients — An observational cohort study. PlosONE. 2018;13(1): e0191185. doi: 10.1371/journal.pone.0191185
- Malishevskaya TN, Dolgova IG, Shatskikh SV, et al. Differential approach to primary open-angle glaucoma treatment. National Journal glaucoma. 2017;16(3):12–17. (In Russ.)
- Lovpache DN, Zavadski PC, Zvereva OG, et al. Compliance and persistence in patients with primary open-angle glaucoma through the doctor opinions. National Journal glaucoma. 2020;19(2):11–21. (In Russ.) doi: 10.25700/NJG.2020.02.02