Vol 20, No 4 (2012)

Articles

IDENTIFICATION HERPES INFECTION, RUBELLA VIRUS IN THE FETUS AND NEWBORN WITH MALFORMATIONS AND SIGNS OF INTRAUTERINE INFECTION

Repina I.B., Feklisova L.V., Kalugina M.U., Klochkov S.A.

Abstract

The examination of smears prints 79 dead fetuses, miscarriages, babies with abnormalities and signs of intrauterine infection in order to determine the frequency of infection with herpes viruses: human herpes virus type 6 (HHV-6), cytomegalovirus (CMV), Epstein-Barr virus (EBV) and rubella virus clarify features of current ante- and neonatal period, causes of death, the definition of histological markers of intrauterine infection.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):8-13
pages 8-13 views

CHARACTERISTICS AND TRENDS OF PRIMARY DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS IN RYAZAN REGION

Panin I.V., Dobin V.L., Oskin D.N.

Abstract

The article is devoted to drug-resistant tuberculosis in the Ryazan region. There is a tendency to the increase of the amount of tubercular patients among women of middle ages. It is stated that in the period from 1999 to 2007 mycobacteria’s structure of drug-resistance has not changed considerably. The exception was a dramatic increase of cases with simultaneous drug-resistance to the four first-line antibiotics. The direct interdependence between the character of drug-resistance and the speed and intensity of tuberculosis microorganisms growth has not been found yet.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):14-19
pages 14-19 views

DIAGNOSTIC VALUE OF THE IMMUNE TO ASSESS THE SEVERITY OF LYMPHOPROLIFERATIVE DISEASE, COMPLICATED BY AN OPPORTUNISTIC INFECTION

Bulieva N.B., Pachotina V.A., Korkin A.L., Uschakov V.F., Schaschkova T.V., Chermeneva N.M.

Abstract

We have studied the results of the survey of cellular and humoral immunity in 260 patients lymphoproliferative diseases, complicated by the development of opportunistic infections. The study of the immunological characteristics of the cells allows you to set the source of origin of the pathological clone of the total diversity of morphologically similar forms limphoproliferativee disease.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):20-27
pages 20-27 views

INFLUENCE OF DEMOGRAPHIC AND TERRITORIAL FACTORS ON PHARMACOEPIDEMIOLOGICAL CHARACTERISTICS OF MEDICINES SUPPLY FOR ASTHMATIC PATIENTS

Karakulova E.V.

Abstract

The pharmacoepidemiological research of medicines supply for asthmatic patients with the influence of the demographic characteristics of patients and a territorial factor was made. The Defined Daily Dose methodology was used. It was determined more intensive consumption of asthma controller therapies in the regional center and more intensive use of symptomatic therapy in the regional districts. Differences in using anti-asthmatic drugs between groups of patients differentiated by sex and age were also found.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):28-33
pages 28-33 views

EXPERIMENTAL VALIDATION OF A GEL BASED ON CHITOSAN ACETATE FOR THE TREATMENT OF BURNS

Pogorelov M.V., Kalinkevich O.V., Ivakhnyuk T.V., Moskalenko F.R., Bonchev S.D., Danilchenko S.N., Sklyar A.M., Kalinkevich A.N., Sikora V.Z., Romanyuk A.N.

Abstract

In the work in vivo test of the gel based on chitosan with additions of miramistin, methyluracil and ascorbic acid were performed. The gel was prepared by solution of 2% chitosan in 0.5% acetic acid during 24h with the subsequent filtration through the glass filter with the average pore size. To obtain the modified gels the above mentioned substances were added to the solution in the proper concentrations. In vivo investigations were conducted using laboratory male rats with the modeled burns of IIB degree, which were randomized in the control and experimental groups. The last 3 days after application of burns, twice a day the wound surface was treated with different modifications of chitosan-based gels. Histological study has shown the decrease of inflammation reaction and edema in biopsy material, acceleration of epithelization on the wound surface and decrease of wound repair terms by 2-3 days. Microbiological investigation revealed the high bacteriostatic action of chitosan gel against the most species of burn surface microflora, which allowed avoiding infectious complications.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):34-45
pages 34-45 views

FINASTERIDE INFLUENCE ON P-GLYCOPROTEIN FUNCTIONAL ACTIVITY

Yakusheva E.N., Chernykh I.V.

Abstract

In the research on rabbits influence of finasteride on the functional activity of the protein efflux transporter P-glycoprotein (Pgp) was studied. Pgp activity was assessed by pharmacokinetic analysis of it’s marker substrate fexofenadine. It was found that the 14-days course of finasteride administration leads to tissue-specific induction of Pgp functional activity in liver and kidney.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):46-50
pages 46-50 views

THE PROBLEM OF THE PREVENTIVE MEASURES OF THE RAIL CAR BUILDING PLANT WORKERS‘ HEALTH DISORDER

Istomin A.V., Sinoda V.A., Shushkova T.S., Ustyushin B.V.

Abstract

The priority factors of the rail car building plant workers' health risk have been detected. The mordibility analysis has been carried out, the risks diseases have been determined. The integral assessment of the functional state of workers' organism has been given. Some hygienic recommendations to provide the safety work conditions and retain the workers’ health have been worked out.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):51-57
pages 51-57 views

DYNAMICS OF TRAFFIC INTENSITY OF MOTOR VEHICLES AND AIR POLLUTION BY THEIR EMISSIONS

Lyapkalo A.A., Dementiev A.A., Tsugran A.M.

Abstract

There are results of sampling study of longstanding dynamics of traffic intensity of motor vehicles, transport conditions and emissions of the main pollutants into the atmospheric air. It is detected that in 1991-2009 on the road traffic routes of the city there was a significant increase in the traffic intensity and deterioration of transport conditions that resulted in a significant increase in air pollution by the emissions of the motor vehicles.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):58-62
pages 58-62 views

CAUSE-EFFECT RELATIONS OF THE ROAD TRAFFIC TRAUMATISM OF CHILDREN

Dedov A.A., Chizhik-Poleiko A.N., Tsomaya V.V.

Abstract

The article is devoted to the uncovering and analysis of the cause-effect relations determining common factors of the origin, prevention, prophylaxis of the road traffic accidents with the participation of children of the preschool age and the primary school age.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):63-69
pages 63-69 views

MEDICAL AND SOCIAL RISK FACTORS FEW CHILDREN URBAN HOUSEHOLDS (FOR EXAMPLE, THE CITY OF RYAZAN)

Medvedeva O.V., Panfilova T.N.

Abstract

The analysis of medical and social risk factors of urban households having few children. Identifying the reasons why families refuse from birth, will determine the reserve births, to develop proposals aimed at optimizing the management of reproductive health and measures to encourage childbirth in region.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):70-72
pages 70-72 views

THE CHARACTERISTISTICS OF ATMOSPHERE POLLUTION BY PRODUCTS OF AUTOMOBILE FUEL COMBUSTION IN THE TERRITORY OF THE ASTRAKHAN REGION IN DYNAMICS FROM 2000 - 2009

Romankova J.N.

Abstract

An investigation of atmosphere pollution by products of automobile fuel combustion was carried on in the Astrakhan region in dynamics from 2000 to 2009. As a result statistically factual stature of unhealthy chemical substances was uncovered. Most chemical substances concentration, possessing action summatsiya, exceeded 1,0 (unit) throughout the entire period of observation. The atmosphere pollution index was characterized as high since 2003.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):73-78
pages 73-78 views

THE SYSTEM OF QUALITY CONTROL OF RENDERING OF MEDICAL CARE IN A MULTI-FUNCTIONAL MEDICAL-PREVENTIVE INSTITUTION

Anichenko P.N., Chirkov V.A.

Abstract

This article describes one of the most effective forms of management of a modern medical institution - a meeting on the organization of management and quality of medical aid. The meeting is held once in a quarter for the improvement of management quality, better continuity between the departments, the organization of the activities of the organization in accordance with the requirements of standards ISO of a series 9001 and is an effective tool for transformation, significantly improves the performance of a medical institution, as well as allow superior integration of the individual processes in a single system.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):79-81
pages 79-81 views

APPROACHES TO FORMATION OF DIFFERENTIAL CAPITATION IN THE STATUTORY HEALTH INSURANCE

Artemeva G.B., Hecht I.A.

Abstract

Modernization of the system of obligatory medical insurance within realization of “Obligatory medical insurance in Russian Federation” law presupposes the usage of graded per capital normatives for the calculation of local obligatory medical insurance programs financing. For the purpose, apart from sex-age coefficients of medical care consumption, it is supposed to use additional indicators characterizing the level of health (sickness rate, mortality, primary disablement) and also such indicators as sanitary-epidemiological and ecological wellbeing of the local areas and the level of medical care availability.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):82-86
pages 82-86 views

PROGNOSTIC VALUE OF MATRIX METALLOPROTEINASE-9 IN THE COURSE OF LEFT VENTRICULAR REMODELING DURING HOSPITAL PERIOD OF ACUTE MYOCARDIAL INFARCTION

Trufanov K.V., Rakita D.R., Vulekh V.M., Nikiforov L.V., Axentiev S.B., Yakushina M.S.

Abstract

Serum matrix metalloproteinase-9 (MMP-9) was assayed at 3-4 days after the first acute myocardial infarction symptoms onset in 36 patients (40-72 years old, 83% male, 89% ST-elevation). Serum concentration of MMP-9 had association with neither sizes nor function of the left ventricular of the heart (LV) assessed by echocardiography performed during hospital admission and before discharge. In contrast, anterior infarction, higher arterial blood pressure during index admission and wall motion index score (WMIS) turned to have positive correlation with LV sizes.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):87-91
pages 87-91 views

EFFECT OF ACUPUNCTURE ON MOTILITY OF THE LARGE INTESTINE IN PATIENTS WITH IRRITABLE BOWEL SYNDROME

Kusnetsov P.S., Butov M.A., Rychagova V.O.

Abstract

As shown by the data of computed electrogastroenterocolography, acupuncture can successfully be used to arrest symptoms associated with disorders in the motor function of the large intestine, in particular, to eliminate pain, constipation and diarrhea in patients with irritable bowel syndrome.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):92-98
pages 92-98 views

ON TIMELY DETECTION OF ACUTE PYELONEPHRITIS PATIENTS WITH DIABETES

Anisimova N.E., Aristarkhov V.G.

Abstract

The paper analyzes data for early detection of acute pyelonephritis in patients with diabetes. The study was conducted from 2006 to 2011 GG The study group included 149 patients with UCP. During the analyzed period (2007-2011 years) was an increase in frequency of the isolation of microbial inoculation microflora from 47.8 to 53.4%. Predominant pathogen infections of the upper urinary tract in patients with diabetes was E.coli - 80-85%, enterococci isolated in 5-6,6%, Pseudomonas, (primarily P. Aeroginosa) at 1.7-3% Streptococcus - 0,7-2,2%.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):99-101
pages 99-101 views

STUDY OF SYSTEMIC INFLAMMATION IN PATIENTS BRONCHIAL ASTHMA IN COMBINATION WITH METABOLIC SYNDROME

Sysoeva M.S., Solovieva A.V., Nikiforova L.V., Rakita D.R.

Abstract

In order to study the systemic inflammation in patients with associated pathology a survey included 48 patients with bronchial asthma, 34 of them were diagnosed with metabolic syndrome, had been performed. In patients with bronchial asthma in association with metabolic syndrome systemic inflammation was more expressed in comparison with patients without metabolic syndrome. An inverse relation between the parameters of respiratory function and C-reactive protein level had been revealed, and it’s concentration increased with the degree of abdominal obesity, severity of atherogenic disorders, fasting glucose levels, with the presence of type 2 diabetes.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):102-106
pages 102-106 views

COMPARATIVE STRUCTURAL-FUNCTIONAL ORGANIZATION OF EPILEPTIC PATIENTS WITH DIFFERENT SEIZURE TYPES

Krivtsova A.Y., Zhadnov V.A.

Abstract

Recent decades have seen significant achievements in scientific research in various fields of epileptology. The tendency of modern neurophysiology is the study of the organization of the nervous processes in terms of the system. A variant of this approach is the theory of functional systems P.K. Anohina. Neurophysiological study was performed of 82 patients with partial, secondary and primary generalized seizure types. It was revealed that the functional structural organization of patients with epilepsy with different types of seizures is vary.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):107-112
pages 107-112 views

PATOGMONICHNYE SYMPTOMS OF CARDIAC ARRHYTHMIAS IN THE AGE STAGES OF CHILD DEVELOPMENT

Ascheulova T.V., Grebova L.P.

Abstract

We studed symptoms arytmies in different age of children. The children had jame peculiarity evolution in any age, structure hard and other organs and systems (displasies and inborn measurements). This symptoms helped to diagnostic arythmies timely.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):113-117
pages 113-117 views

OPERATION NEUROTIZATION FOR IRREPERABLE NERVE DEFECTS OF UPPER EXTRIMITIES

Khodjamurodov G.M.

Abstract

In the article the problem of irreperable nerve defects is being considered as well as the possibilities to solve this problem through the operations of neurotization. In total 10 operations of neurotization were performed which is simple on technical performance and to achieve the same results identical to the direct reconstruction of nerves. Achieved results is stimulating for more wides application in cases when the direct reconstruction is more complicated and time and work consuming.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):118-122
pages 118-122 views

A CONDITION OF CONNECTIVE TISSUE AND A BLOOD FLOW IN THE SPERMATIC CORD IN MEN WITH INGUINAL HERNIAS, AS FACTORS OF SURGICAL TACTICS OF TREATMENT

Fedoseev A.V., Muravyev S.Y., Uspenskiy I.I., Faleev V.V.

Abstract

The paper studies the influence of severity of undifferentiated connective tissue dysplasia and changes in blood flow through the vessels of the spermatic cord in 36 men with inguinal hernias who underwent open Preperitoneal hernioplasty with “PROLENE” mesh. The average term of life with hernia was 21,5 months. Symptoms of connective tissue dysplasia revealed in 35 (97,2%) patients. The average speed of blood flow decreases from 11,9 cm/s in patients with mild UCTD to 9 cm/s - with a severe and shortage of blood flow increased from 12,5% to 25%. The difference between average speed of blood flow on the affected and healthy side, which before surgery was 2,78 cm/s, decreased to 1,0 cm/s, i.e. almost three times. Deficiency of blood flow before the herniotomy was 19,62%, after surgical treatment - 5,45%. Tension methods of hernioplasty cause a persistent decrease in average speed of blood flow on the affected side, even after several years.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):123-130
pages 123-130 views

PECULIARITIES OF DIAGNOSTICS AND TREATMENT POSTTRAUMATIC HEMOBILIA

Huseinov A.Z., Karapysh D.V., Petushkov L.L.

Abstract

The article describes the exploration and currency of posttraumatic hemobilia in the surgical department. The frequency of the disease is 0,18 - 3%. The lethality in case of hemobilia is still high (20-40%) in spite of the new diagnostic and treatment methods usage. The concrete clinic example demonstrates probable mistakes in diagnostics and possible methods to liquidate them; the algorithm of treatment is defined. The article describes further ways of posttraumatic hemobilia diagnostic improvement in the conditions of the surgery department in Russian Federation. The method of selective angiography should be installed necessarily as an invasive method of diagnostics and treatment of these conditions in the stationary of the 21 st century.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):131-135
pages 131-135 views

MORPHOLOGICAL STUDY OF STRUCTURE PULP USAGE THE INTEGRATED PRODUCT

Chen W., Morozova S.I., Kazantseva G.P., El Uazzani M., Bezmen S.A., Babuchkina E.S.

Abstract

In an experimental evaluation of the effectiveness of an integrated preparation based on royal jelly and phytoecdysteroids in the treatment of deep caries.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):136-141
pages 136-141 views

RESEARCHING OF CARBOHYDRATE STRUCTURE OF SOME FAMILY ASTERACEAE PLANTS

Botov A.Y., Severin A.P., Yatsuk V.Y., Siplivaya L.E.

Abstract

In this article we have presented the results of the carbohydrate composition (water-soluble polysaccharide complex and pectins) research of some Asteraceae family species. We have also determined qualitative and quantitative composition of water-soluble polysaccharide complex and pectins by means of physico-chemical methods. The possibility of expanding resource base has been shown for obtaining medicinal products. It has become possible through the introduction of new medicinal plants of Erigeron genus and integrated use of the genus Artemisia plants.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):142-145
pages 142-145 views

ISOLATION, PHYSICOCHEMICAL RESEARCH AND DETERMINATION OF SOLUBILIZATING ACTIVITY TANACETUM VULGARE FLOWERS POLYSACCHARIDES

Kirichenko E.E., Sytchev Y.A., Chekulaeva G.Y.

Abstract

From Tanacetum vulgare flowers was isolated polysaccharide; some of its physicochemical properties and solubilizating activity were studied, and also was suggested a new standardization method of this plant’s raw product.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):146-150
pages 146-150 views

CORRECTION OF ENDOTHELIAL DYSFUNCTION: CURRENT STATUS OF THE PROBLEM (LITERATURE REVIEW)

Suchkov I.A.

Abstract

The abstract represents major causes, consequences and methods of correction of endothelial dysfunction according to the data published in Russian and foreign literature.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):151-157
pages 151-157 views

MODERN TECHNOLOGIES OF TREATMENT OF CANDIDIASIS OF ORAL MUCOSA

Mezhevikina G.S., Morozova S.I., Savelyeva N.A., Bezmen S.A.

Abstract

The article is devoted to the review of the modern literary data regarding modern medicines used for treatment of candidiasis of oral mucosa. Classification, summary, harmful effects of modern medicines are described separately.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):158-163
pages 158-163 views

NEW CONCEPTS OF PHARMACODYNAMICS OF ECDYSTEROIDS

Shchulkin A.V., Yakusheva E.N., Davydov V.V., Darmograi V.N.

Abstract

In the review possible mechanisms of action of ecdysteroids in an organism of mammals are discussed: introduction in the lipid membrane; interaction with the special membrane receptors; interaction with the regulatory site of the receptors of the different molecules; activation nonspecial adaptation program.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):164-169
pages 164-169 views

OPTICAL COHERENT THE TOMOGRAPHY IN DIAGNOSTICS AMBLYOPIA AT CHILDREN

Sokolov V.A., Al-Sharufi A.K.

Abstract

One of the most often of the reasons of incomplete visual acuity is its functional decrease - amblyopia. It is observed amblyopia at ametropia high degrees, at astigmatism, it is especial at anizometropia, more often at a squint, at cataracts, congenital cataracts, optical nistagm, and also at patients with functional frustration of the central nervous system. Optical coherent tomography (OCT) has allowed to see objective changes of the central departments of a retina at amblyopia. However the data on these of change are inconsistent. The review is devoted to role OCT in diagnostics amblyopia.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):170-173
pages 170-173 views

ON REHABILITATION OF DRUG ADDICTS IN PREVENTING DRUG CRIME

Turovsky I.V.

Abstract

The article deals with the legal aspects of teaching social rehabilitation of drug addicts in the system of crime prevention.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):174-179
pages 174-179 views

"PAID" MEDICINE IN THE RUSSIAN FEDERATION: THEORY AND PRACTICE

Boyko I.B., Boyko O.I.

Abstract

Actual problems of national health care - health care in the "paid" and "free" versions. Author's opinion on this issue is based on the provisions of the legislation in the health and status of the delivery of health services.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):180-184
pages 180-184 views

MODERN STATE OF THE PROBLEM IMPACTS MULTIPLE INTENSIVE LABOUR IN MEDICINE

Kharitonov V.I.

Abstract

This article presents the theoretical and practical aspects of the problem of intensive labour medicine influences multifactorial. Is the need to take into account the quantitative contribution of factors with the concomitant action for predicting the degree of real professional risk injury and prioritization of proposed preventive measures. Shows the importance of experimental and industrial research to assess the composite factors of different nature on individual reactions.
I.P. Pavlov Russian Medical Biological Herald. 2012;20(4):185-188
pages 185-188 views

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