电邮这篇文章 Original experimental model of tuberculosis and lung cancer
- 作者: Kudriashov G.G.1, Nefedov A.O.1, Tochilnikov G.V.2, Zmitrichenko Y.G.2, Krylova Y.S.1, Dogonadze M.Z.1, Zabolotnyh N.V.1, Dyakova M.E.1, Esmerdyaeva D.S.1, Vitovskaya M.L.1, Gavrilov P.V.1, Azarov A.A.1, Zhuravlev V.Y.1, Vinogradova T.I.1, Yablonskii P.K.1
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隶属关系:
- St. Petersburg Research Institute of Phthisiopulmonology
- N.N. Petrov Oncology Research Institute
- 期: 卷 13, 编号 5 (2022)
- 页面: 33-42
- 栏目: Original studies
- URL: https://journals.eco-vector.com/pediatr/article/view/110977
- DOI: https://doi.org/10.17816/PED13533-42
- ID: 110977
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BACKGROUND: The potential relationship between pulmonary tuberculosis and lung cancer has been the subject of intense interest over the past few decades. Nevertheless, the features of the pathogenesis of concomitant pathology remain poorly studied.
AIM: The ain of the study to develop an experimental model of the concomitant pathology of tuberculosis and lung cancer.
MATERIALS AND METHODS: The study was performed on mice of the C57BL/6 line at the age of two months in four groups: 1st — intact mice (n = 12), 2nd — mice without a tumor infected with tuberculosis (n = 24), 3rd — tumor-bearing mice not infected with tuberculosis (n = 23), 4th — tumor-bearing mice infected with tuberculosis (n = 24). Individual and group parameters were evaluated using the SPSS Statistica v23 software package.
RESULTS: Tumor was developed at the site of primary transplantation in all mice from groups 3 and 4, which was confirmed by visual assessment and the results of histological examination. Tumor growth in the main group was significantly less than in the control group of the tumor, which may be due to intoxication against the background of tuberculosis infection. All infected mice from groups 2 and 4 developed pulmonary tuberculosis, confirmed by computed tomography of the lungs, bacteriological and histological examination of lung samples. Mycobacterial load in the lungs was the highest in animals with concomitant pathology of tuberculosis and tumor. The survival rate of mice was determined to a large extent by tumor growth rather than by the progression of tuberculosis infection.
CONCLUSIONS: The results of the study indicate the possibility of creating an experimental biological model of the concomitant pathology of tuberculosis and lung cancer in mice. The features of the course of the concomitant pathology were revealed: Lewis lung epidermoid carcinoma develops more slowly in tuberculosis infected animals than in the tumor control group; the development of the tuberculosis process in mice with a tumor occurs more intensively than in the tuberculosis infection control group. The survival rate of mice with concomitant pathology is determined more by the intensity of tumor growth than by the progression of tuberculosis.
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作者简介
Grigorii Kudriashov
St. Petersburg Research Institute of Phthisiopulmonology
编辑信件的主要联系方式.
Email: dr.kudriashov.gg@yandex.com
MD, PhD, Senior Research Associate, Thoracic Surgery Center
俄罗斯联邦, Saint PetersburgAndrey Nefedov
St. Petersburg Research Institute of Phthisiopulmonology
Email: herurg78@mail.ru
MD, PhD, Senior Research Associate, Thoracic Surgery Center
俄罗斯联邦, Saint PetersburgGrigorii Tochilnikov
N.N. Petrov Oncology Research Institute
Email: gr75@mail.ru
MD, PhD, Head of the Scientific Laboratory of Cancer Chemoprophylaxis and Oncopharmacology
俄罗斯联邦, Saint PetersburgYuliya Zmitrichenko
N.N. Petrov Oncology Research Institute
Email: zmitrichenko@gmail.com
Junior Research Associate, Scientific Laboratory of Cancer Chemoprophylaxis and Oncopharmacology
俄罗斯联邦, Saint PetersburgYuliya Krylova
St. Petersburg Research Institute of Phthisiopulmonology
Email: emerald2008@mail.ru
MD, PhD, Senior Research Associate, Center for Molecular Biomedicine
俄罗斯联邦, Saint PetersburgMarine Dogonadze
St. Petersburg Research Institute of Phthisiopulmonology
Email: marine-md@mail.ru
MD, PhD, Senior Research Associate
俄罗斯联邦, Saint PetersburgNataliya Zabolotnyh
St. Petersburg Research Institute of Phthisiopulmonology
Email: info@spbniif.ru
MD, PhD, Dr. Sci. (Med.), Leading Research Associate
俄罗斯联邦, Saint PetersburgMarina Dyakova
St. Petersburg Research Institute of Phthisiopulmonology
Email: info@spbniif.ru
MD, PhD, Senior Research Associate
俄罗斯联邦, Saint PetersburgDilyara Esmerdyaeva
St. Petersburg Research Institute of Phthisiopulmonology
Email: info@spbniif.ru
MD, PhD, Senior Research Associate
俄罗斯联邦, Saint PetersburgMaria Vitovskaya
St. Petersburg Research Institute of Phthisiopulmonology
Email: mariavit72@mail.ru
MD, PhD, Senior Research Associate
俄罗斯联邦, Saint PetersburgPavel Gavrilov
St. Petersburg Research Institute of Phthisiopulmonology
Email: spbniifrentgen@mail.ru
MD, PhD, Leading Research Associate
俄罗斯联邦, Saint PetersburgArtem Azarov
St. Petersburg Research Institute of Phthisiopulmonology
Email: azardoc0@gmail.com
Postgraduate Student
俄罗斯联邦, Saint PetersburgVyacheslav Zhuravlev
St. Petersburg Research Institute of Phthisiopulmonology
Email: vy.zhuravlev@spbniif.ru
MD, PhD, Leading Research Associate
俄罗斯联邦, Saint PetersburgTatyana Vinogradova
St. Petersburg Research Institute of Phthisiopulmonology
Email: ti.vinogradova@spbniif.ru
MD, PhD, Dr. Sci. (Med.), Project Leader
俄罗斯联邦, Saint PetersburgPiotr Yablonskii
St. Petersburg Research Institute of Phthisiopulmonology
Email: piotr_yablonskii@mail.ru
MD, PhD, Dr. Sci. (Med.), Director
俄罗斯联邦, Saint Petersburg参考
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