电邮这篇文章 Clinical implication of the Hydrogen Breath Test for diagnosis of lactose intolerance and overgrows syndrome in infants
- 作者: Korniyenko Y.A.1, Kubalova S.S.1, Dmitriyenko M.A.2, Dzhagatspanyan I.E.2
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隶属关系:
- Saint-Petersburg State Pediatric Medical University
- Association of Medicine and Analytics
- 期: 卷 4, 编号 1 (2013)
- 页面: 9-15
- 栏目: Articles
- URL: https://journals.eco-vector.com/pediatr/article/view/1178
- DOI: https://doi.org/10.17816/PED419-15
- ID: 1178
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详细
The aim of this study was to estimate the diagnostic value of the Hydrogen Breath Test (HBT) in diagnosis of lactose intolerance (LI) and overgrows syndrome (OS) in infants with functional gastrointestinal disorders (FGD). 102 infants from 1 to 6 months with FGD symptoms were investigated by HBT with lactose, fecal microbiota were examined by culture and real time PCR, fecal calprotectin was measured. LI was found in 37 % FGD infants, OS in 60 %. Calprotectin level was 445 ± 28 mg/g in OS and 195 ± 27 mg/g in infants without OS. Microbiota was altered in all FGD infants with increase of Cl. difficile, St. aureus. Infants with LI got Lactase Baby, infants with OS-L. reuteri in infant formula NAN Comfort or in drops Rela Life. Both were effective in elimination of FGD symptoms. Calprotectin level and microbiota disturbances were better after treatment.
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作者简介
Yelena Korniyenko
Saint-Petersburg State Pediatric Medical University
Email: elenkornienk@yandex.ru
MD, Prof., Head of the Gastroenterology Department, Faculty of Postgraduate Education
Saida Kubalova
Saint-Petersburg State Pediatric Medical University
Email: saidakubalova@mail.ru
Postgraduate Student, Gastroenterology Department, Faculty of Postgraduate Education
Marina Dmitriyenko
Association of Medicine and Analytics
Email: mari_alexa@mail.ru
PhD, General Director
Igor Dzhagatspanyan
Association of Medicine and Analytics
Email: drjie@mail.ru
PhD, Director of the Development Department
参考
- Готтшалк Г. Метаболизм бактерий. — М., Мир, 1982.
- Коваленко А. А., Гасилина Т. В., Бельмер С. В. Метеоризм: норма и патология // Лечащий врач. — 2008. — № 2. — С. 38–43. http://ip.medart.tomsk.ru/ucm/search/result.xml?query=rec.id %3D %22 %D0 %9B653687 %2F2008 %2F2 %22.
- Bedell G. N., Marhall R., Dubois A. B. et al. Measurement of the volume of gas in the gastrointestinal tract; values in normal subjects and ambulatory patients // J. Clin. Invest. — 1956. — Vol. 35. — P. 336–345.
- Bouhnik Y., Alain S., Attar A. et al. Bacterial populations contaminating the upper gut in patients with small intestinal bacterial overgrowth syndrome // Am. J. Gastroenterol. — 1999. — Vol. 94. — P. 1327–1331.
- Corazza G. R., Strocchi A., Rossi R. Sorbitol malabsorption innormal volunteers and in patients with coeliac disease // Gut. — 1988. — Vol. 29. — P. 44–48.
- Corazza G. R., Menozzi M. G., Strocchi A. et al. The diagnosis of small bowel bacterial overgrowth. Reliability of jejunal culture and inadequacy of breath hydrogen testing // Gastroenterology. — 1990. — Vol. 98. — P. 302–309.
- Di Camillo M., Witter F. R., Bronner Y. et al. Hydrogen breathtest for diagnosis of lactose malabsorption: the importance of timing and the number of breath samples // Can. J. Gastroenterol. — 2006. — Vol. 20. — P. 265–268.
- Gasbarrini A., Corazza G. R., Gasbarrini G., Montalto M. 1st Rome H 2-Breath Testing Consensus Conference Working Group. Methodology and indications of H 2-breath testing in gastrointestinal diseases: the Rome Consensus Conference // Aliment. Pharmacol. Ther. — 2009, Mar 30. — Vol. 29(suppl. 1). — P. 1–49.
- Hawrelak J. A., Myers S. P. The causes of intestinal dysbiosis: a review // Altern. Med. Rev. — 2004. — Vol. 9. — P. 180–197.
- Husebye E. The pathogenesis of gastrointestinal bacterial overgrowth // Chemotherapy. — 2005. — Vol. 51. — P. 1–22.
- Koshini R., Dai S. C., Lezcano S. et al. A systematic review of diagnostic tests for small intestinal bacterial overgrowth // Dig. Dis. Sci. — 2008. — Vol. 53. — P. 1443–1454.
- Levitt M. D. Volume and composition of human intestinal gas determined by means of an intestinal washout technique // N. Engl. J. Med. — 1971. — Vol. 284. — P. 1394–1398.
- Levitt M. D., Donaldson R. M. Use of respiratory hydrogen (H2) excretion to detect carbohydrate malabsorption // J. Lab. Clin. Med. — 1970. — Vol. 75. — P. 937–945.
- Newcomer A. D., McGill D. B., Thomas P. J. et al. Prospective comparison of indirect methods for detecting lactase deficiency // N. Engl. J. Med. — 1975. — Vol. 293. — P. 1232–1235.
- Strocchi A., Corazza G. R., Anania C. Quality control study of H 2 breath testing for the diagnosis of carbohydrate malabsorption in Italy // Ital. J. Gastroenterol. Hepatol. — 1997. — Vol. 29. — P. 122–127.
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