Blood-brain barrier: peculiarities of structural and functional organization in patients with glioblastoma
- Authors: Sklyar S.S.1,2, Trashkov A.P.2,3, Matsko M.V.4,5,6, Konevega A.L.2,3, Kopaeva M.Y.3, Cherepov A.B.3, Tsygan N.V.7,2, Safarov B.I.1, Voinov N.E.1, Vasiliev A.G.8
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Affiliations:
- Polenov Russian Neurosurgical Institute — the Branch of Almazov National Medical Research Centre
- B.P. Konstantinov Petersburg Nuclear Physics Institute of National Research Centre “Kurchatov Institute”
- National Research Center “Kurchatov Institute”
- Clinical Scientific-Practical Center of Oncology
- Saint Petersburg State University
- St. Petersburg Medico-Social Institute
- Kirov Military Medical Academy
- St. Petersburg State Pediatric Medical University
- Issue: Vol 13, No 5 (2022)
- Pages: 99-108
- Section: Reviews
- URL: https://journals.eco-vector.com/pediatr/article/view/119982
- DOI: https://doi.org/10.17816/PED13599-108
Cite item
Abstract
The research of the blood-brain barrier began at the turn of the 18th–19th centuries. To date due to the large number of studies conducted, it is obvious that this system has an impossibly complex structure at the organ, tissue and molecular genetic levels. Scientific interest in the changes in the blood-brain barrier that occur during pathological neoplastic processes is increasing. As it turned out, the restructuring of this system is an important and integral stage in the pathogenesis of glioblastoma, a tumor of the central nervous system with the most unfavorable prognosis. Heterogeneous structure with the formation of areas of altered cellular composition, uneven and uncontrolled permeability, provided by a large number of transport vesicles and the destruction of tight contacts between endotheliocytes, active outflow of molecules from the parenchyma due to the continuous synthesis of new portions of ABC-carrier proteins, the creation of an immature vascular network under the influence of high expression of VEGF by tumor cells — the main characteristics of the hematopoietic barrier, formed in glioblastoma and supporting its survival. The further research of the features of the structure and mechanisms of functioning of the blood-brain barrier in glioblastoma is a new and promising task in modern neuro–oncology, the solution of which will not only expand the understanding of the biology of the most common and malignant brain tumor but will also improve the effectiveness of treatment of patients and improve the prognosis.
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About the authors
Sofia S. Sklyar
Polenov Russian Neurosurgical Institute — the Branch of Almazov National Medical Research Centre; B.P. Konstantinov Petersburg Nuclear Physics Institute of National Research Centre “Kurchatov Institute”
Author for correspondence.
Email: s.sklyar2017@yandex.ru
MD, PhD, Junior Research Associate, Laboratory of Neurooncology, Polenov Russian Neurosurgical Institute – the Branch of Almazov National Medical Research Centre; Junior Research Associate, Center for Preclinical and Clinical research, St. Petersburg B.P. Konstantinov Institute of Nuclear Physics
Russian Federation, Saint Petersburg; Saint PetersburgAlexander P. Trashkov
B.P. Konstantinov Petersburg Nuclear Physics Institute of National Research Centre “Kurchatov Institute”; National Research Center “Kurchatov Institute”
Email: alexander.trashkov@gmail.com
Head, Center of Preclinical and Clinical Research, St. Petersburg B.P. Konstantinov Institute of Nuclear Physics; Head of the Neurocognitive Research Resource Center, National Research Center Kurchatov Institute
Russian Federation, Saint Petersburg; MoscowMarina V. Matsko
Clinical Scientific-Practical Center of Oncology; Saint Petersburg State University; St. Petersburg Medico-Social Institute
Email: marinamatsko@mail.ru
MD, PhD, Dr. Sci. (Med.), Leading Research Associate, Clinical Scientific-Practical Center of Oncology; Assistant Professor, Department of Oncology, Saint Petersburg State University; Associate Professor, Department of Oncology, St. Petersburg Medico-Social Institute
Russian Federation, Saint Petersburg; Saint Petersburg; Saint PetersburgAndrey L. Konevega
B.P. Konstantinov Petersburg Nuclear Physics Institute of National Research Centre “Kurchatov Institute”; National Research Center “Kurchatov Institute”
Email: konevega_al@pnpi.nrcki.ru
MD, PhD, Head, Department of Molecular and Radiation Biophysics, St. Petersburg B.P. Konstantinov Institute of Nuclear Physics; Head of the Department of Biomedical Technologies, National Research Center Kurchatov Institute
Russian Federation, Saint Petersburg; MoscowMarina Yu. Kopaeva
National Research Center “Kurchatov Institute”
Email: m.kopaeva@mail.ru
Research Associate, Laboratory of Neuroscience National Research Center Kurchatov Institute
Russian Federation, MoscowAnton B. Cherepov
National Research Center “Kurchatov Institute”
Email: ipmagus@mail.ru
Lead Engineer, Center for Neurocognitive Research
Russian Federation, MoscowNikolai V. Tsygan
Kirov Military Medical Academy; B.P. Konstantinov Petersburg Nuclear Physics Institute of National Research Centre “Kurchatov Institute”
Email: 77th77@gmail.com
MD, PhD, Dr. Sci. (Med.), Associate Professor, Department Neurology, Kirov Military Medical Academy; Leading Research Associate, St. Petersburg B.P. Konstantinov Institute of Nuclear Physics
Russian Federation, Saint Petersburg; Saint PetersburgBobir I. Safarov
Polenov Russian Neurosurgical Institute — the Branch of Almazov National Medical Research Centre
Email: safarovbob@mail.ru
MD, PhD, Head, 4th Department
Russian Federation, Saint PetersburgNikita E. Voinov
Polenov Russian Neurosurgical Institute — the Branch of Almazov National Medical Research Centre
Email: nik_voin@mail.ru
Neurosurgeon
Russian Federation, Saint PetersburgAndrei G. Vasiliev
St. Petersburg State Pediatric Medical University
Email: avas7@mail.ru
MD, PhD, Dr. Sci. (Med.), Head, Pathophysiology Department
Russian Federation, Saint PetersburgReferences
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