Prerequisites to improvement of predictive model of childhood Hodgkin’s lymphoma

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Abstract


Background. Calculation of relative tumor burden in Hodgkin’s lymphoma patients is the simplest and significant parameter which can be used in daily clinical practice as a risk factor. The aim of study was the assessment of influence of relative tumor burden on the late results of a disease. Material and methods. This research included data on 126 patients with Hodgkin’s lymphoma aged from 0 till 18 years (middle age of 11 years), treated risk-adapted treatment according to the DAL-HD and SPBLH-05. Boys was 70, girls - 56 (a ratio 1,25 : 1). Fifty-eight patients (46 %) are stratified in favorable risk group, 50 (39,7 %) - in intermediate risk group, and 50 (39,7 %) are included in unfavorable risk group. Results. Overall survival at 5 years was 93 % (range 91-95 %), event-free survival - 88 % (85-91 %). The average relative tumor burden was 129,4 cm3/m2 (7-609,7 cm3/m2). When carrying out ROC-analysis value of 122,7 cm3/m2 (р ˂ 0,0001) appeared the critical parameter, which worsen the prognosis of a disease. Overall survival in a patients cohort with this volume was 69,6 %, with the volume less than 122,7 cm3/m2 overall survival was 97,2 % (р = 0,00002). Conclusions. The relative tumor burden is the parameter which is significantly reducing survival rates in children with Hodgkin’s lymphoma. Opinion on interrelation of clinical and laboratory parameters with “sarkoma’s saturation” or tumor volume as end result of immunological frustration, it is represented the most perspective direction of studying of Hodgkin’s lymphoma.

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About the authors

Svetlana Aleksandrovna Kulyova

N.N. Petrov Research Institute of Oncology

Email: Kulevadoc@yandex.ru
MD, PhD, Dr Med Sci, Professor, Head. Department of Children`s Chemotherapy and Combined Modality Therapy

Andrei Petrovich Karitsky

N.N. Petrov Research Institute of Oncology

Email: Kulevadoc@yandex.ru
MD, PhD, Head. Hospital

Svetlana Viacheslavovna Ivanova

N.N. Petrov Research Institute of Oncology

Email: Kulevadoc@yandex.ru
Department of Children`s Chemotherapy and Combined Modality Therapy

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Copyright (c) 2015 Kulyova S.A., Karitsky A.P., Ivanova S.V.

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