Hormonal regulation of postnatal growth from birth to age six months in Small-for-Gestational - Age children

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Abstract


This article is devoted to the investigation hormonal mechanisms of postnatal growth from birth to age six months in small for gestational age children (SGA) with asymmetrical and asymmetrical IUGR. The IGF-1 and GH levels, insulin sensitivity (by homeostasis model assessment (HOMA-IR)) were measured blood at 3 and 6 months of age. The prospective study includes 40 SGA infants (group 1) - 24 - with asymmetrical (1a) and 16 with symmetrical IUGR babies (1b) and 17 appropriate for gestational age (AGA) infants (group 2). Most SGA infants showed rapid, or “catch-up” postnatal growth. Symmetrical IUGR infants with “catch-up” growth had higher IGF-1 and growth GH levels at 3 month of age than asymmetrical IUGR with “catch-up” growth (p < 0,05). From 3 to 6 months of age 77 % of infants with “catch-up” growth showed retardation of growth velocity. At 6 month of age SGA infants with “catch-up” growth had lower IGF-1, GH blood levels and HOMA-IR than at 3 months of age (p < 0,05). Infants without “catch-up” growth had similar hormone levels at 3 and 6 months of age. We suppose, that these changes of “GH - IGF-1” axis and insulin sensitivity at age 3 and 6 months in SGA infants are the mechanisms, which promote the postnatal growth. It can be assumed that the same mechanisms may underlie metabolic disorders in later life.

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About the authors

Kristina F Islamova

Federal Almazov North-West Medical Reserch Centre

Author for correspondence.
Email: kislamova81@mail.ru

Russian Federation Researcher. Research laboratory of Physiology and Pathology of the newborns

Dmitriy O Ivanov

St Petersburg State Pediatric Medical University

Email: doivanov@yandex.ru

Russian Federation MD, PhD, Dr. Med. Sc, Prof, Acting Rector

Yuriy V Petrenko

St Petersburg State Pediatric Medical University

Email: alez1964@yandex.ru

Russian Federation MD, PhD, Acting Rector of clinical work

Elizaveta A Kurzina

Federal Almazov North-West Medical Reserch Centre

Email: elizavetakurzina@yandex.ru

Russian Federation MD, PhD, neonatologist of department of neonates diseases

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Copyright (c) 2016 Islamova K.F., Ivanov D.O., Petrenko Y.V., Kurzina E.A.

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