Primary hyperparathyroidism in childhood

Cover Page

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Primary hyperparathyroidism is a disease caused by excessive production of parathyroid hormone by the parathyroid glands. Most often, sporadic cases of the disease occur. In the family form of hyperparathyroidism, as well as in the syndrome of multiple endocrine neoplasia, the disease is caused by genetic changes. In manifest forms of the disease, hyperparathyroidism leads to destruction and deformation of bone tissue, osteoporosis, urolithiasis, cholelithiasis, pancreatitis, peptic ulcer disease, and disorders of mineral and electrolyte metabolism. Bone manifestations of the disease can lead to disability of the child. The article presents the experience of surgical treatment of 15 children, patients with primary hyperparathyroidism, aged from 6 to 18 years old, 10 of them girls and 5 boys operated in the period from 1973 to 2017. The main methods of diagnosis of the disease, the difficulties of timely diagnostic are discussed. The features of laboratory indicators of clinical manifestations of the disease are clearly shown. The clinical manifestations of primary hyperparathyroidism in children differed from adults more heavily damage of bone tissue with the development of gross deformities of the limbs. In 8 (57.3%) of 15 children, manifest forms of the disease were diagnosed. In 7 (46.7%) children, parathyroid adenomas were detected and removed during surgery for various thyroid diseases. In two patients, parathyroid adenomas were removed during operations performed for a genetically confirmed syndrome of multiple endocrine neoplasia of type IIa. In this study, the features of adenoma localization of the parathyroid gland, the possibility of surgical treatment and the dynamics of clinical manifestations after surgery are discussed. Proper treatment allowed to achieve full recovery.

Full Text

Restricted Access

About the authors

Alexandr V. Gostimsky

St. Petersburg State Pediatric Medical University

Author for correspondence.
Email: gostimsky@mail.ru

MD, PhD, Dr Med Sci, Professor, Head, Department of General Medical Practice

Russian Federation, St. Petersburg

Zoya S. Matveeva

St. Petersburg State Pediatric Medical University

Email: ikar122@list.ru

MD, PhD, Assistant Professor, Department of Hospital Surgery with Traumatology and Military Surgery Courses

Russian Federation, St. Petersburg

Anatoliy F. Romanchishen

St. Petersburg State Pediatric Medical University

Email: afromanchishen@mail.ru

MD, PhD, Dr Med Sci, Professor, Head, Department of Hospital Surgery with Traumatology and Military Surgery Courses

Russian Federation, St. Petersburg

Igor V. Karpatskiy

St. Petersburg State Pediatric Medical University

Email: ivspb@mail333.com

MD, PhD, Associate Professor, Department of General and Medical Chemistry

Russian Federation, St. Petersburg

Sergey S. Peredereev

St. Petersburg State Pediatric Medical University

Email: speredereev@yandex.ru

Resident doctor, Surgical Department No 3

Russian Federation, St. Petersburg

Oleg V. Lisovskiy

St. Petersburg State Pediatric Medical University

Email: oleg.lisovsky@rambler.ru

MD, PhD, Associate Professor, Department of General and Medical Chemistry

St. Petersburg

Victor V. Pogorelchuk

St. Petersburg State Pediatric Medical University

Email: viktor-pogorelchuk@yandex.ru

MD, PhD, Associate Professor, Department of General and Medical Chemistry

Russian Federation, St. Petersburg

References

  1. Голохвастов Н.Н. Гиперкальциемия. Первичный гиперпаратиреоз. – СПб.: Гиппократ, 2003. – 136 с. [Golohvastov NN. Primary hyperparathyroidism. Saint Petersburg: Gippokrat; 2003. 136 p. (In Russ.)]
  2. Гостимский А.В., Романчишен А.Ф., Матвеева З.С. Первичный гиперпаратиреоз у ребенка 14 лет. Эндокринная хирургия 2003–2014 гг. Российский симпозиум с международным участием. [Gostimskiy AV, Romanchishen AF, Matveeva ZS. Primary hyperparathyroidism in 14-th years old child. Endokrinnaya hirurgiya 2003-2014. (Conference proceedings) Rossijskij simpozium s mezhdunarodnym uchastiem. (In Russ.)]
  3. Гостимский А.В., Романчишен А.Ф., Матвеева З.С. Первичный гиперпаратиреоз в детском возрасте. Современные аспекты хирургической эндокринологии: материалы XIX Российского симпозиума с международным участием. 15–17 сентября 2010 г. – Челябинск: Изд-во Челябинской государственной медицинской академии, 2010. – 96 c. [Gostimskiy AV, Romanchishen AF, Matveeva ZS. Primary hyperparathyroidism in childhood. Sovremennye aspekty hirurgicheskoj ehndokrinologii. (Conference proceedings) XIX rossijskiy simpozium s mezhdunarodnym uchastiem. 2010 sep 15-17. Chelyabinsk: Chelyabinskaya gosudarstvennaya medicinskaya akademiya; 2010. 96 p. (In Russ.)]
  4. Гостимский А.В., Передереев С.С. Современные проблемы хирургического лечения больных диффузным токсическим зобом детского возраста // Педиатр. – 2013. – Т. 4. – № 4. – С. 69–76. [Gostimskiy AV, Peredereev SS. Surgical treatment of diffuse toxic goiter in children. Pediatr. 2013;4(4):69-76. (In Russ.)]
  5. Гостимский А.В. Хирургическое лечение детей и подростков с патогенетически разным раком щитовидной железы: автореф. дис. … д-ра мед. наук. – СПб.: СПбГПМУ, 2009. [Gostimskiy AV. Surgical treatment of children and teenagers with pathogenetic different cancer of a thyroid gland. [dissertation] Saint Petersburg: SPbGPMU; 2009. (In Russ.)]
  6. Гостимский А.В., Скородок Ю.Л., Дитковская Л.В. Токсическая аденома щитовидной железы у детей // Вестник хирургии им. И.И. Грекова. – 2007. – Т. 166. – № 2. – С. 89–90. [Gostimskiy AV, Skorodok YuL, Ditkovskaya LV. Toxic adenoma of a thyroid gland at children. Vestnik khirurgii im. I.I. Grekova. 2007;166(2):89-90. (In Russ.)]
  7. Николаев О.В., Таркаева В.Н. Гиперпаратиреоз. – М., 1974. – 264 с. [Nikolaev OV, Tarkaeva VN. Hyperparathyroidism. Moscow; 1974. 264 p. (In Russ.)]
  8. Allen DB, Friedman AL, Hendricks SA. Asymptomatic primary hyperparathyroidism in children. Newer methods of preoperative diagnosis. Arch Pediatr Adolesc Med. 1986;140(8):435-437.
  9. Harman CR, van Heerden JA, Farley DR, et al. Sporadic primary hyperparathyroidism in young patients. A separate disease entity? Arch Surg. 1999;134(6):651-656. doi: 10.1001/archsurg.134.6.651.
  10. Hsu SC, Levine MA. Primary hyperparathyroidism in children and adolescents: the Johns Hopkins Children’s Center experience 1984-2001. J Bone Miner Res. 2002;17(Suppl2):44-50.
  11. Kollars J, Zarroug AE, van Heerden J, et al. Primary hyperparathyroidism in pediatric patients. Pediatrics. 2005;115(4):1073. doi: 10.1542/peds.2004-0804.
  12. Lawson ML, Miller SF, Ellis G, et al. Primary hyperparathyroidism in a paediatric hospital. J Med. 1996;89:921-932. doi: 10.1093/qjmed/
  13. 12.921.
  14. Muller H. Sex, age and hyperparathyroidism. Lancet. 1969;1:449-450. doi: 10.1016/S0140-6736(69)91484-6.

Supplementary files

There are no supplementary files to display.

Statistics

Views

Abstract: 335

PDF (Russian): 185

Dimensions

Article Metrics

Metrics Loading ...

PlumX


Copyright (c) 2017 Gostimsky A.V., Matveeva Z.S., Romanchishen A.F., Karpatskiy I.V., Peredereev S.S., Lisovskiy O.V., Pogorelchuk V.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies