The influence of vital stress experienced by women in pregravidarum period on sexual development of their daughters

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Abstract


Comparative evaluation of sexual development among adolescent girls whose mothers experienced and did not experience psychological trauma associated with life-threatening was conducted. The physiological features of sexual development in girls in the Republic of Dagestan, whose mothers experienced a high risk of terror threat in pregravidarum period were identified. It was determined that in pre-pubertal period the concentration of luteinizing and follicle-stimulating hormone in peripheral blood in girls whose mothers experienced stress associated with life-threatening was significantly higher than in girls of the control group. In prepubertal period in girls whose mothers experienced a vital stress, the earlier decrease in the activity of the adrenal cortex in the transition from prepuberty to puberty was observed. Girls whose mothers experienced a vital stress can be characterized by an earlier menarche, at the age of 10-12 the menarche occurred significantly more often than in the control group. The anthropometric data show an earlier maturation of these girls under the age of 12. In the prepubertal period the formation of breast and pubic hair growth were ahead of girls in the control group. Thus, girls whose mothers experienced vital stress are characterized by an earlier and at the same time disharmonious puberty. They are characterized by earlier menarche, delayed rhythm of the menstrual cycle and some changes in humoral regulation rhythm. Thus, it is vital the stress suffered by women before pregnancy causes changes in hormonal regulation in pregnancy that leads to long-term damage of physiological homeostasis of the offspring.


Kepiya T. Temirkhanova

Author for correspondence.
temkep@yandex.ru
Research Institute of Experimental Medicine of North-Western Region of RAMS
Russian Federation, Saint Petersburg

MD, PhD, doctoral student, Physiological division named after I. P. Pavlov

Sergey G. Tsikunov

sectsykunov@yandex.ru
Research Institute of Experimental Medicine of North-Western Region of RAMS
Russian Federation, Saint Petersburg

MD, PhD, Dr Med Sci, Professor, Head, Research Laboratory of Psychophysiology of Emotions Physiological Division named after I.P. Pavlov

Elena D. Pyatibrat

e5brat@yandex.ru
Military Medical Academy named after S.M. Kirov
Russian Federation, Saint Petersburg

MD, PhD, Dr Med Sci, Senior teacher, Department of Pharmacology

Aleksandr O. Pyatibrat

e5brat@yandex.ru
A.M. Nikiforov Federal Russian Center for Emergency and Radiation Medicine
Russian Federation, Saint Petersburg

MD, PhD, Dr Med Sci, Leading Scientist, Head, Research Department of Organization of Scientific Activity

  • Баранов А.А., Кучма В.Р., Сухарева Л.М., и др. Универсальная оценка физического развития младших школьников. – М., 2010. – 34 с. [Baranov AA, Kuchma VR, Sukhareva LM, et al. Universal assessment of physical development of Junior schoolchildren. Moscow; 2010. 34 p. (In Russ.)]
  • Гланц С. Медико-биологическая статистика: пер. с англ. – М.: Практика, 1998. – 459 с. [Glants S. Biomedical statistics. Moscow: 1998. 459 p. (In Russ.)]
  • Ямпольская Ю.А. Физическое развитие школьников Москвы к началу XXI века. Здоровье, обучение, воспитание детей и молодежи в XXI веке: материалы междунар. конгр. – М., 2004. – Ч. III. – С. 395–396. [Yampol’skaya Yu.A. Physical development of schoolchildren of Moscow to the beginning of the XXI century. Health, training, education of children and youth in the XXI century. (Conference proceedings). Moscow; 2004. Part III. P. 395-396. (In Russ.)]
  • Ястребов В.С. Терроризм и психическое здоровье (масштаб проблемы, толерантность населения, организация помощи) // Журн. неврологии и психиатрии им. С.С. Корсакова. – 2004. – № 6. – С. 4–8. [Yastrebov VS. Terrorism and mental health (the scale of the problem, the tolerance of the population, organization of care). Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2004;(6):4-8. (In Russ.)]
  • Apolone G, et al. Post traumatic stress disorder (letter). New England Journal of Medichine. 2002;346(19):
  • -1498. doi: 10.1056/NEJM200205093461913.
  • Bale TL. Lifetime stress experience: transgenerational epigenetics and germ cell programming. Dialogues in Clinical Neuroscience. 2014;16(3):297-305.
  • Bleich A, et al. Exposure to terrorism, stress-related mental health symptoms, and coping behaviors among a nationally representative sample in Israel. JAMA. 2003;290(5):612-620. doi: 10.1001/jama.290.5.612.
  • Braga LL, et al. Transgenerational transmission of trauma and resilience: a qualitative study with Brazilian offspring of Holocaust survivors. BMC Psychiatry. 2012;12:134-136. doi: 10.1186/1471-244X-.
  • -134.
  • Casas E, Vavouri T. Sperm epigenomics: challenges and opportunities. Frontiers in Genetics. 2014;5:330-331.
  • Rodgers AB, et al. Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress. Proc Natl Acad Sci. 2015;112(44):13699-13704. doi: 10.1073/pnas.1508347112.
  • Tanner JM. Normal growth and techniques ofgrowth assessment: Review. J Clin Endocrinol Metab. 1986; 15(3):411-451. doi: 10.1016/S0300-595X(86)80005-6.

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