Levels IL-4, IL-8, TNF-α in middle-aged men with stented coronary arteries after repeated myocardial revascularization

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Background. It has now been established that inflammatory cytokines are involved in all the stages of the development of coronary heart disease. It has been scientifically proved that the severity of coronary heart disease directly correlates with the increase in the level of proinflammatory cytokines, while data on the role of proinflammatory interleukin IL-8 and anti-inflammatory interleukin IL-4 are contradictory.

The aim of the study was to evaluate the levels of proinflammatory cytokines (IL-8, TNF-α) and anti-inflammatory interleukin (IL-4) in patients with various forms of coronary heart disease who underwent re-stenting of the coronary arteries.

Materials and methods. By the method of enzyme-linked immunosorbent assay, the levels of cytokines were determined in 28 patients who had previously undergone myocardial infarction with stenting of an infarct-related artery, re-admitted due to the development of acute coronary syndrome, who underwent repeated stenting of coronary arteries. The same method was performed on 24 patients who also had previously undergone myocardial infarction with stenting of the infarction-associated artery, who were admitted to the clinic for staged stenting of the coronary arteries.

Results. In patients with chronic coronary syndrome the levels of IL-4 a do not exceed the reference values, in patients with acute coronary syndrome the levels of IL-4 there was an increase 3,70±0,24 and 359,80±66,94 pg/ml, р ≤ 0,001. In patients with chronic coronary syndrome the levels of IL-8 a do not exceed the reference values, in patients with acute coronary syndrome the levels of IL-8 there was an increase 7,34±1,29 and 69,75±18,25 pg/ml, р ≤ 0,001.

Conclusions. The increase in the level of IL-4 has a compensatory character and, along with a slight increase in TNF-α, can be considered as a positive factor stabilizing the course of the disease.

Full Text

Restricted Access

About the authors

Vladimir S. Vasilenko

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: vasilenkovladi@yandex.ru

MD, PhD, Dr. Sci. (Med.), Professor, Head, Department of Hospital Therapy with Military Therapy and Occupational Medicine Courses

Russian Federation, Saint Petersburg

Elena A. Kurnikova

Saint Petersburg State Budget Institution Health Care, City Hospital № 26

Email: kurnikovaelena221281@yandex.ru

MD, PhD, Head of Regional Vascular Center

Russian Federation, Saint Petersburg

Vadim A. Gostimskiy

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

Email: gostimsky@hotmail.com

postgraduate student, Department of Hospital Therapy with Military Therapy and Occupational Medicine Courses

Russian Federation, Saint Petersburg

Sergey V. Shenderov

Saint Petersburg State Budget Institution Health Care, City Hospital № 26

Email: s.shenderov@mail.ru

MD, PhD, Head of Separation Endovascular Surgery

Russian Federation, Saint Petersburg

Aleksandr E. Blinov

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

Email: aleks.blinov@mail.ru

Researcher, Research Center

Russian Federation, Saint Petersburg

Olga N. Varlamova

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

Email: ol.varlamova@bk.ru

Researcher, Research Center

Russian Federation, Saint Petersburg

Elena A. Dement’eva

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

Email: zorra2@yandex.ru
Russian Federation, Saint Petersburg

References

  1. Жукова Н.С., Шахнович Р.М., Меркулова И.Н., и др. Спонтанная диссекция коронарных артерий//Кардиология. 2019. Т. 59, № 9. С. 52–63. [Zhukova NS, Shakhnovich RM, Merkulova IN, et al. Spontaneous Coronary Artery Dissection. Kardiologiia. 2019;59(9): 52-63. (In Russ.)] doi: 10.18087/cardio.2019.9.10269
  2. Кардиоваскулярная профилактика 2017. Национальные рекомендации. [Интернет]. М., 2017. – 288 с. [Kardiovaskulyarnaya profilaktika 2017. Natsional’nye rekomendatsii. [Internet]. Moscow, 2017. 288 p. (In Russ.)] Доступ по ссылке: https://scardio.ru/content/Guidelines/Cardiovascular-prof-2017.pdf
  3. Староверов И.И., Шахнович Р.М., Гиляров М.Ю., и др. Евразийские клинические рекомендации по диагностике и лечению острого коронарного синдрома с подъемом сегмента ST (ОКСпST)//Евразийский кардиологический журнал. 2020. T. 1. C. 4–77. [Staroverov II, Shakhnovich RM, Gilyarov MYu, et al. Eurasian clinical guidelines on diagnosis and treatment of acute coronary syndrome with ST segment elevation (STEMI). Eurasian Heart Journal. 2020;1:4-77. (In Russ.)] doi: 10.38109/2225-1685-2020-1-4-77
  4. Bajraktari G, Jashari H, Ibrahimi P, et al. Complete revascularization for patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease: a meta-analysis of randomized trials. Coron Artery Dis. 2018;29(3): 204-215. doi: 10.1097/MCA.0000000000000602
  5. Cui K, Lyu S, Song X, et al. Long-Term Safety and Efficacy of Staged Percutaneous Coronary Intervention for Patients with ST-Segment Elevation Myocardial Infarction and Multivessel Coronary Disease. Am J Cardiol. 2019;124(3):334-342. doi: 10.1016/j.amjcard.2019.04.048
  6. Elgendy IY, Mahmoud AN, Kumbhani DJ, et al. Complete or culprit-only revascularization patients with multivessel coronary artery disease undergoing percutaneous coronary interven- tion for: a pairwise and network meta-analysis of randomized trials. JACC Cardiovasc Interv. 2017;10(4):315-324. doi: 10.1016/j.jcin.2016.11.047
  7. Fioranelli M, Bottaccioli AG, Bottaccioli F, et al. Stress and inflammation in coronary artery disease: a review psychoneuroendocrineimmunology-based. Frontiers in Immunology. 2018;9:2031. doi: 10.3389/fimmu.2018.02031
  8. George J, Mathur R, Shah AD, et al. Ethnicity and the first diagnosis of a wide range of cardiovascular diseases: Associations in a linked electronic health record cohort of 1 million patients. PLoS One. 2017;12(6): e0178945. doi: 10.1371/journal.pone.0178945
  9. Helwani MA, Amin A, Lavigne P, et al. Etiology of Acute Coronary Syndrome after Noncardiac Surgery. Anesthesiology. 2018;128(6):1084-1091. doi: 10.1097/ALN.0000000000002107
  10. Khera AV, Kathiresan S. Is coronary atherosclerosis one disease or many? Setting realistic expectations for precision medicine. Circulation. 2017;135(11):1005-1007. doi: 10.1161/CIRCULATIONAHA.116.026479
  11. Kolkailah AA, Alreshq RS, Muhammed AM, et al. Transradial versus transfemoral approach for diagnostic coronary angiography and percutaneous coronary intervention in people with coronary artery disease. Cochrane Database Syst Rev. 2018;4(4): CD012318. doi: 10.1002/14651858.CD012318.pub2
  12. Martins TB, Anderson JL, Muhlestein JB, et al. Risk factor analysis of plasma cytokines in patients with coronary artery disease by a multiplexed fluorescent immunoassay. Am J Clin Pathol. 2006;125(6):906-913. doi: 10.1309/Q3E6-KF0Q-D3U3-YL6T
  13. Mc Namara K, Alzubaidi H, Jackson JK. Cardiovascular disease as a leading cause of death: how are pharmacists getting involved? Integr Pharm Res Pract. 2019;8:1-11. doi: 10.2147/IPRP.S133088
  14. Min X, Lu M, Tu S, et al. Serum cytokine profile in relation to the severity of coronary artery disease. Biomed Res Int. 2017;2017:4013685. doi: 10.1155/2017/4013685
  15. Mirzaei H, Ferns GA, Avan A. Cytokines and microRNA in coronary artery disease. Adv Clin Chem. 2017;82:47-70. doi: 10.1016/bs.acc.2017.06.004
  16. Moreno Velásquez I, Gajulapuri A, Leander K, et al. Serum IL8 is not associated with cardiovascular events but with all-cause mortality. BMC Cardiovasc Disord. 2019;19(1):34. doi: 10.1186/s12872-019-1014-6
  17. Osman M, Khan SU, Farjo PD, et al. Meta-analysis comparing complete versus infarct-related artery revascularization in patients with ST-elevation myocardial infarction and multivessel coronary disease. Am J Cardiol. 2020;15;125(4):513-520. doi: 10.1016/j.amjcard.2019.11.017
  18. Pimor A, Auffret V, Didier R, et al. Immediate complete revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease treated by primary percutaneous coronary intervention: Insights from the ORBI registry. Arch Cardiovasc Dis. 2018;111(11):656-665. doi: 10.1016/j.acvd.2017.08.005
  19. Pineda AM, Carvalho N, Gowani SA, et al. Managing multivessel coronary artery disease in patients with ST-elevation myocardial infarction: a comprehensive review. Cardiol Rev. 2017;25(4):179-188. doi: 10.1097/CRD.0000000000000110
  20. Pothineni NVK, Subramany S, Kuriakose K, et al. Infections, atherosclerosis, and coronary heart disease. Eur Heart J. 2017;38(43):3195-3201. doi: 10.1093/eurheartj/ehx362
  21. Естественное движение населения в разрезе субъектов Российской Федерации за январь–декабрь 2018 года [интернет]. [Estestvennoe dvizhenie naselenija v razreze sub#ektov Rossiiskoi Federacii za janvar’–dekabr’ 2018 goda. [internet] (In Russ.)] Режим доступа: https://www.gks.ru/free_ doc/2018/demo/edn12-18.htm. Дата обращения: 03.09.2021.

Copyright (c) 2021 Vasilenko V.S., Kurnikova E.A., Gostimskiy V.A., Shenderov S.V., Blinov A.E., Varlamova O.N., Dement’eva E.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies