心肌重建术后冠状动脉支架置入术的中年男性IL-4、IL-8和TNF-α水平的研究

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绪论。目前，已经确定炎症细胞因子参与了冠心病发展的各个阶段。已有科学证明，冠心病的严重程度与促炎细胞因子水平的增加直接相关，而促炎白细胞介素IL-8和抗炎白细胞介素IL-4的作用数据相互矛盾。

本研究的目的是评估反复冠脉支架置入的各种冠心病患者的促炎细胞因子（IL-8，TNF-α）和抗炎白细胞介素（IL-4）水平。

材料与方法。通过固相酶免疫分析的方法，对28例曾发生心肌梗死并支架植入术的梗死相关动脉患者进行细胞因子测定，这些患者因急性冠状动脉综合征的发展而再次住院，并进行了冠状动脉反复支架植入术。对24例慢性心脏病患者的细胞因子水平进行了测定，这些患者此前曾发生心肌梗死，并对梗死相关动脉进行支架植入术，这些患者入院接受分期冠状动脉支架植入术。

结果。慢性冠脉综合征患者IL-4水平在参考值范围内，急性冠脉综合征患者IL-4水平升高分别为3.70±0.24和359.80±66.94pg/ml，p≤0.001。慢性冠脉综合征患者IL-8水平也在参考值范围内，而急性冠脉综合征组IL-8分别升高7.34±1.29和69.75±18.25pg/ml，p≤0.001。

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作者简介

Vladimir Vasilenko

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

编辑信件的主要联系方式.
Email: vasilenkovladi@yandex.ru

MD, PhD, Dr. Sci. (Med.), Professor, Head, Department of Hospital Therapy with Military Therapy and Occupational Medicine Courses

俄罗斯联邦, Saint Petersburg

Elena Kurnikova

Saint Petersburg State Budget Institution Health Care, City Hospital № 26

Email: kurnikovaelena221281@yandex.ru

MD, PhD, Head of Regional Vascular Center

俄罗斯联邦, Saint Petersburg

Vadim Gostimskiy

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

Email: gostimsky@hotmail.com

postgraduate student, Department of Hospital Therapy with Military Therapy and Occupational Medicine Courses

俄罗斯联邦, Saint Petersburg

Sergey Shenderov

Saint Petersburg State Budget Institution Health Care, City Hospital № 26

Email: s.shenderov@mail.ru

MD, PhD, Head of Separation Endovascular Surgery

俄罗斯联邦, Saint Petersburg

Aleksandr Blinov

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

Email: aleks.blinov@mail.ru

Researcher, Research Center

俄罗斯联邦, Saint Petersburg

Olga Varlamova

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

Email: ol.varlamova@bk.ru

Researcher, Research Center

俄罗斯联邦, Saint Petersburg

Elena Dement’eva

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

Email: zorra2@yandex.ru
俄罗斯联邦, Saint Petersburg

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版权所有 © Vasilenko V., Kurnikova E., Gostimskiy V., Shenderov S., Blinov A., Varlamova O., Dement’eva E., 2021

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