Current diagnostics of the childhood urolithiasis


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The review considers diagnostic aspects of renal stone disease, or urolithiasis (UL) in children. Population prevalence and clinical features of pediatric UL are under discussion, along with most effective visualization approaches. Different risk factors of the kidney stone disease are considered, including various metabolic, climatic and ecological disorders, e. c., hyperoxaluria, hypercalciuria, certain local microbial infections, such as Proteus mirabilis, Corynebacterium urealytica, Ureaplasma urealytica etc.) Some specific features of clinical symptomatology in childhood urolytiasis are also under consideration. Protective mechanisms of the local Tamm-Horsfall protein and high citrate production are discussed. This protein performs some antiinfectious functions, as well stabilizes a complex salt balance in the urine, thus increasing solubility threshold for the salts. We have noted that prevalence of the high-molecular-weight 28 MDa isoform of the Tamm-Horsfall protein over the 7-MDa form seems to be an important protective factor in potential development of urolytiasis. We mention here a number of rare genetic syndromes is listed which cause specific inherited disorders of calcium, hyperoxaluria, or uric acid salts accumulation. In summary, we postulate a need of individualized diagnostics of urinary metabolic markers in the UL patients, in order to arrange metaphylactic measures, in order to prevent recurrent formation of kidney stones and possible urolythiasis episodes in future.

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作者简介

Vladimir Emanuel

State Budget Educational Institution “The First St. Petersburg State Medical University”

Email: vladimirem1@gmail.com
MD, PhD, Dr Med Sci, Professor, Chief, Department of Clinical Laboratory Diagnostics with a Course of Molecular Medicine

Aleksey Chukhlovin

Saint Petersburg State Pediatric Medical University

Email: alexei.chukh@mail.ru
MD, PhD, Dr Med Sci Professor, Head, Laboratory of Molecular Diagnostics with a group for Ecogenetics, Research Center

Anna Tretjak

Saint Petersburg State Pediatric Medical University

Email: a.t.tretiak@gmail.com
Research Associate, Laboratory of Molecular Diagnostics with a group for Ecogenetics, Research Center

Lubov Vostokova

Saint Petersburg State Pediatric Medical University

Email: vostokova50@mail.ru
Research Associate, Laboratory of Molecular Diagnostics with a group for Ecogenetics, Research Center

Maria Sevostianova

State Budget Educational Institution “The First St. Petersburg State Medical University”

Email: mari-svn@yandex.ru
Department Resident Doctor, Department of Clinical Laboratory Diagnostics with a Course of Molecular Medicine

参考

  1. Ланда С. Б., Егоров В. В., Чухловин А. Б. Применение метода динамического светорассеяния для исследования обратимых мегамолекулярных комплексов белка Тамма-Хорсфалла и их роли в ранней диагностике уролитиаза. Клинико-лабораторный консилиум. 2008; 6: 33-8.
  2. Черепанова Е. В., Дзеранов Н. К. Факторы риска возникновения мочекаменной болезни у детей. Урология. 2007; 6: 87-90.
  3. Чухловин А. Б., Эмануэль Ю. В., Напалкова О. В., Ланда С. Б., Эмануэль В. Л. Роль локальных инфекций в генезе мочекаменной болезни. Нефрология. 2011; 15 (3): 11-17.
  4. Эмануэль В. Л. Лабораторная диагностика заболеваний почек (2-е изд., испр. и доп.). СПб.: Триада. 2006.
  5. Asplin J. R., Parks J. H., Nakagawa Y., Coe F. L. Reduced crystallization inhibition by urine from women with nephrolithiasis. Kidney Int. 2002; 61: 1821-29.
  6. Cameron J. S., Moro F., Simmonds H. A. Gout, uric acid and purine metabolism in paediatric nephrology. Pediat. Nephrol. 1993; 7: 105-18.
  7. Cameron M. A., Sakhaee K., Orson W. M. Nephrolithiasis in children. Pediat. Nephrol. 2005; 20: 1587-92.
  8. Coe F. L., Parks J. H. Pathogenesis and treatment of nephrolithiasis. The Kidney (D. Seldin and G. Giebisch eds). Philadelphia: Lippincott Williams and Wilkins; 2000: 1841-67.
  9. Coe F. L., Evans A., Worcester E. Kidney stone disease. J. Clin. Invest. 2005; 115: 2598-2608.
  10. Copelovitch L. Urolithiasis in children: medical approach. Pediat. Clin. North Am. 2012; 59: 881-96.
  11. Coward R. J. M., Peters C. J., Duffy P. G., Corry D., Kellett M. J., Choong S. et al. Epidemiology of paediatric renal stone disease in the UK. Arch. Dis. Child. 2003; 88: 962-65.
  12. Dello Strologo L., Pras E., Pontesilli C. Comparison between SLC3A1 and SLC7A9 cystinuria patients and carriers: a need for a new classification. J. Am. Soc. Nephrol. 2002; 13: 2547-53.
  13. Grover P. K., Ryall R. L., Marshall V. R. Calcium oxalate crystallization in urine: role of urate and glycosaminoglycans. Kidney Int. 1992; 41: 149-54.
  14. Hess B., Michel R., Takkinen R. Risk factors for low urinary citrate in calcium nephrolithiasis: low vegetable fiber and low urine volume to be added to the list. Nephrol. Dial. Transplant. 1994; 9: 642-49.
  15. Kokorowski P. J., Hubert K., Nelson C. P. Evaluation of pediatric nephrolithiasis. Indian J. Urol. 2010; 26: 531-35.
  16. Koyun M., Güven A. G., Filiz S., Akman S., Akbas H., Baysal Y. E. et al. Screening for hypercalciuria in schoolchildren: what should be the criteria for diagnosis? Pediat. Nephrol. 2007; 22: 1297-301.
  17. Kruse K., Kracht U., Kruse U. Reference values for urinary calcium excretion and screening for hypercalciuria in children and adolescents. Eur. J. Pediatr. 1984; 143 (1): 25-31.
  18. Lorenz-Depiereux B., Benet-Pages A., Eckstein G. Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3. Am. J. Hum. Genet. 2006; 78: 193-201.
  19. Maxfield M. Fractionation of the urinary mucoprotein of Tamm and Horsfall. Arch. Biochem. 1960; 89: 281-85.
  20. McKay C. P. Renal stone disease. Pediat. Rev. 2010; 31: 179-88.
  21. Meagher T., Sukumar V. P., Collingwood J., Crawley T., Schofield D., Henson J. Low dose computed tomography in suspected acute renal colic. Clin. Radiol. 2001; 56: 873-76.
  22. Okamoto N., Aruga S., Matsuzaki S., Takahashi S., Matsushita K., Kitamura T. Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls. Int. J. Urol. 2007; 14: 344-9.
  23. Porowski T., Zoch-Zwierz W., Konstantynowicz J., Taranta-Janusz K. A new approach to the diagnosis of children′s urolithiasis based on the Bonn Risk Index. Pediat. Nephrol. 2008; 23: 1123-28.
  24. Parks J. H., Coe F. L. A urinary calcium-citrate index for the evaluation of nephrolithiasis. Kidney Int. 1986; 30: 85-90.
  25. Parks J. H., Coward M., Coe F. L. Correspondence between stone formation and urine supersaturation in nephrolithiasis. Kidney Int. 1997; 51: 894-900.
  26. Parks J. H., Worcester E. M., O’Connor R. C., Coe F. L. Urine stone risk factors in nephrolithiasis patients with and without bowel disease. Kidney Int. 2003; 63: 255-65.
  27. VanDervoort K., Wiesen J., Frank R. Urolithiasis in pediatric patients: a single center study of incidence, clinical presentation and outcome. J. Urol. 2007; 177: 2300-5.
  28. Vezzoli G., Tanini A., Ferrucci L., Soldati L., Bianchin C., Franceschelli F. et al. Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients. J. Am. Soc. Nephrol. 2002; 13: 2517-23.
  29. Zasloff M. Antimicrobial peptides, innate immunity, and the normally sterile urinary tract. J. Am. Soc. Nephrol. 2007; 18: 2810-16.

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版权所有 © Emanuel V.L., Chukhlovin A.B., Tretjak A.T., Vostokova L.P., Sevostianova M.Y., 2014

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