Hormonal regulation of postnatal growth from birth to age six months in Small-for-Gestational - Age children

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

This article is devoted to the investigation hormonal mechanisms of postnatal growth from birth to age six months in small for gestational age children (SGA) with asymmetrical and asymmetrical IUGR. The IGF-1 and GH levels, insulin sensitivity (by homeostasis model assessment (HOMA-IR)) were measured blood at 3 and 6 months of age. The prospective study includes 40 SGA infants (group 1) - 24 - with asymmetrical (1a) and 16 with symmetrical IUGR babies (1b) and 17 appropriate for gestational age (AGA) infants (group 2). Most SGA infants showed rapid, or “catch-up” postnatal growth. Symmetrical IUGR infants with “catch-up” growth had higher IGF-1 and growth GH levels at 3 month of age than asymmetrical IUGR with “catch-up” growth (p < 0,05). From 3 to 6 months of age 77 % of infants with “catch-up” growth showed retardation of growth velocity. At 6 month of age SGA infants with “catch-up” growth had lower IGF-1, GH blood levels and HOMA-IR than at 3 months of age (p < 0,05). Infants without “catch-up” growth had similar hormone levels at 3 and 6 months of age. We suppose, that these changes of “GH - IGF-1” axis and insulin sensitivity at age 3 and 6 months in SGA infants are the mechanisms, which promote the postnatal growth. It can be assumed that the same mechanisms may underlie metabolic disorders in later life.

全文:

受限制的访问

作者简介

Kristina Islamova

Federal Almazov North-West Medical Reserch Centre

编辑信件的主要联系方式.
Email: kislamova81@mail.ru
Researcher. Research laboratory of Physiology and Pathology of the newborns 俄罗斯联邦

Dmitriy Ivanov

St Petersburg State Pediatric Medical University

Email: doivanov@yandex.ru
MD, PhD, Dr. Med. Sc, Prof, Acting Rector 俄罗斯联邦

Yuriy Petrenko

St Petersburg State Pediatric Medical University

Email: alez1964@yandex.ru
MD, PhD, Acting Rector of clinical work 俄罗斯联邦

Elizaveta Kurzina

Federal Almazov North-West Medical Reserch Centre

Email: elizavetakurzina@yandex.ru
MD, PhD, neonatologist of department of neonates diseases 俄罗斯联邦

参考

  1. D’Ercole AJ, Applewhite GT, Underwood LE. Evidence that somatomedin is synthesized by multiple tissues in the fetus. Dev Biol. 1980;75:315-328. doi: 10.1016/0012-1606(80)90166-9.
  2. Harding JE, Liu L, Evans PC, Gluckman PD. Insulin-like growth factor 1 alters feto-placental protein and carbohydrate metabolism in fetal sheep.
  3. Endocrinology. 1994;134:1509-1514. doi: 10.1210/endo.134.3.8119193.
  4. Fowden AL. The role of insulin in prenatal growth.
  5. J Dev Physiol. 1989;12:173-82.
  6. Johnson TR, Blossey BK, Denko CW, Ilan J. Expression of insulin-like growth factor I in cultured rat hepatocytes: effects of insulin and growth hormone. Mol Endocrinol. 1989;3:580-587. doi: 10.1210/mend-3-3-580.
  7. Randhawa RS. The insulin-like factor system and fetal growth restriction. Ped Endocrinol Rev. 2008;6(2): 235-240.
  8. Yang SW, Yu JS. Relationship of insulin-like growth factor-I, insulin-like growth factor binding protein-3, insulin, growth hormone in cord blood and maternal factors with birth height and birthweight. Pediatr Internat. 2000;42:31-36. doi: 10.1046/j.1442-200x.2000.01167.x.
  9. Wan G, Yu S, Liu J. Serum concentration of insulin-like growth factor-I in cord blood. Zhonghua Fu Chan Ke Za Zhi. 1998 Dec;33(12):720-1.
  10. Исламова К.Ф., Петренко Ю.В., Иванов Д.О., Филиппова С.Н. Изменения в оси «инсулиноподобный фактор роста –1 — соматотропный гормон» и инсулиновой чувствительности тканей у детей, родившихся с задержкой внутриутробного развития // Вестник современной клинической медицины. — 2014. — Т. 7. — № 6. — С. 32–38. [Islamova KF, Ivanov DO, Petrenko YuV, Filippova SN. Changes in “insulin-like growth factor -1 — growth hormone” axis and insulin sensitivity in children born small for gestational age. Vestnik sovremennoj klinicheskoj mediciny. 2014;7(6):32-38. (In Russ)].
  11. Fliesen T, Maiter D, Gerard G, et al. Reduction of serum insulin-like growth factor-I by dietary protein restriction is age dependent. Pediatr Res. 1989;26:415-419. doi: 10.1203/00006450-198911000-00010.
  12. Holl RW, Snehotta R, Siegler B, et al. Binding protein for human growth hormone: effects of age and weight. Horm Res. 1991;35:190-197. doi: 10.1159/000181901.
  13. Gluckman PD, Gunn AJ, Wray A, et al. Congenital idiopathic growth hormone deficiency associated with prenatal and early postnatal growth failure. The International Board of the Kabi Pharmacia International Growth Study. J Pediatr. 1992;121:920-923. doi: 10.1016/S0022-3476(05)80342-7.
  14. Albertsson-Wikland K, Boguszewski M, Karlberg J. Children born small-for-gestational age: postnatal growth and hormonal status. Hormone Research. 1998;49, Suppl. 2:7-13. doi: 10.1159/000053080.
  15. Karlberg J PE, Albertsson-Wikland K, Kwan EYW, et al. The timing of early postnatal catch-up growth in normal, full-term infants born short for gestational age. Hormone Research. 1997;48, supplement 1:17-24. doi: 10.1159/000191279.
  16. Williams JPG, Tanner JM, Hughes PCR. Catch-up growth in male rats after growth retardation during the suckling period. Pediatric Research. 1974;8:149-156. doi: 10.1203/00006450-197403000-00001.
  17. McMillen IC, Robinson JS. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev. 2005;85:571-63. doi: 10.1152/physrev.00053.2003.
  18. Ong KK, Ahmed ML, Emmett PM, et al. Association between postnatal catch-up growth and obesity in childhood: prospective cohort study. BMJ. 2000;320:967-971. doi: 10.1136/bmj.320.7240.967.
  19. Ong KK, Petry CJ, Emmett PM, et al. ALSPAC study team 2004 Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels. Diabetologia. 2004;47:1064-1070. doi: 10.1007/s00125-004-1405-8.
  20. Ibanez L, Ong KK, Dunger DB, de Zegher F. Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestational-age children. J Clin Endocrinol Metab. 2006;91:2153-2158. doi: 10.1210/jc.2005-2778.
  21. Soto N, Bazaes RA, Pena V, et al. Insulin sensitivity and secretion are related to catch-up growth in small-for-gestational-age infants at age 1 year: results from a prospective cohort. J Clin Endocrinol Metab. 2003;88:3645-3650. doi: 10.1210/jc.2002-030031.
  22. Nigel J. Crowther, et al. Influence of Catch-up Growth on Glucose Tolerance and β-Cell Function in 7-Year-Old Children: Results from the Birth to Twenty Study. Pediatrics. 2008;121: e1715-e1722.
  23. Ong KK, Petry CJ, Emmett PM, et al. ALSPAC study team 2004 Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels. Diabetologia. 2004;47:1064-1070. doi: 10.1007/s00125-004-1405-8.
  24. Юрьев В.В., Симаходский А.С., Воронович А.С., Хомич М.М. Рост и развитие ребенка. — СПб., 2007. — 197 с. [Yuryev VV, Simahodskiy AS, Voronovich AS, Homich MM. Child growth and development. Saint Petersburg; 2007. 197 p. (In Russ)].
  25. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-419. doi: 10.1007/BF00280883.
  26. Blum WH, Breier BH. Radioimmunoassays for IGFs and IGFBPs. Growth Regulation. 1994;4, Suppl. 1:11-19.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Islamova K.F., Ivanov D.O., Petrenko Y.V., Kurzina E.A., 2016

Creative Commons License
此作品已接受知识共享署名 4.0国际许可协议的许可
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 69634 от 15.03.2021 г.


##common.cookie##