Vol 24, No 8 (2013)

The innate immunity factors involved in the development of complications, such as habitual miscarriage, fetal growth restriction, and intrauterine infection, are considered. Their role in the formation of local defense and their interaction with the normal vaginal microflora are covered. An understanding of the role of pathophysiological mechanisms implicated in a local immune response in the development of intrauterine infection will be able to improve diagnostic methods and to timely apply a package of preventive measures to reduce obstetric complications.

Pregnancy in women with chronic renal failure (persistent decline in glomerular filtration rate (GFR) below 60 ml / min) is associated with an increased incidence of obstetric and perinatal complications. The article provides a description of concepts CKD and ESRD, data on the nature and frequency of pregnancy complications in chronic renal failure, the prevention of preeclampsia in pregnant women with renal insufficiency with heparin, antiplatelet drugs and progestins.

Mitral valve prolapse (MVP) is the most investigated valve defects of cardiac connective tissue and common structural and functional impairments of the cardiac valvular apparatus. Data on causes of MVP in children, its clinical manifestations, and possible complications are given.

The paper describes a case of a patient with resistant hypertension, who has successfully undergone renal denervation.

The paper presents data on the safety of medicines used during pregnancy to treat nausea (vomiting) and acid-dependent diseases.

The analysis of experimental and clinical researches of medicines with potassium and magnesium application is given. The effectiveness of the given medicines for prevention of cardiovascular complications with patients with arterial hypertension and ischemic heart disease is shown.

Apical hypertrophic cardiomyopathy occurs at any age, may lead to sudden cardiac death, and frequently appears as angina attacks and ECG changes: ST-segment depression and T-wave inversion in the left chest leads. The diagnostic determinant is echocardiography performed by a highly qualified specialist.

The paper shows the high clinical and hematological efficiency of using a continuous erythropoietin receptor activator in combination with parenteral iron (III) dextran hydroxide versus monotherapy with the latter. The combined use was noted to be satisfactorily tolerated and to cause no side effects.

At different levels of the investigation, the author studied the pathomorphology of the heart in 3 types of secondary dilated cardiomyopathies (alcoholic, ischemic, and neuroleptic) at the manifestation stage characterized by obvious chronic heart failure. By this time, the process of cardiac remodeling is already over at the organ level. The progression of myocardial dysfinction is associated with the further progression of myocardial microstructural injuries.

With advances in neonatal care for babies born at early gestational ages, there is an annual increase in the number of patients with bronchopulmonary dysplasia and its consequences in older age and in those with congenital bronchopulmonary malformations. In this connection, the bronchological methods for diagnosis and treatment, which can reveal anatomic and functional features, increase the scope of practice of pulmonologists and endoscopists. These methods allow for detecting defects and developmental features as soon as possible, which prevents life-threatening complications.

The risk factors of atherosclerosis, the blood levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and cytokines (interleukins (IL) -1, -6, -8, and-10 and tumor necrosis factor-α (TNF-α) were determined in patients with ischemic stroke (IS). The authors analyze whether the above indicators might be correlated with each other and the magnitude of clinical and laboratory parameters, by keeping in mind these parame-ters in a group of healthy individuals. Examining the cytokine system revealed the hyperproduc-tion of pro-inflammatory (IL-1, IL-6, IL-8, and TNF-α) and anti-inflammatory (IL-10) cytokines. A direct correlation was found between the severity of IS and the level of IL-1 β: the higher the level of a cytokine was, the severer the patient status and the worse the prognosis were.

Many investigations of the efficiency of laser therapy as part of combination treatment for both adults and children have proven its high efficiency that can substantially reduce the duration of treatment.