Vol 26, No 8 (2015)

The paper considers general issues relating to the management and nutrition of obese patients on the basis of 16 English-language guidelines from the professional communities of European countries, the USA, and Australia, which have been published in the past 4 years.

The paper gives an update on drug-induced liver injury and particularly drug-induced hepatitis in pregnant women, as well as a number of the authoґs clinical observations. It describes the risk factors, main mechanisms, and clinical types of drug-induced liver injuries, as well as the principles of their diagnosis and treatment in pregnant women.

Testing a hypothesis for the prethermal stimulation of blood microcirculation in the area of irradia-tion during low-intensity laser therapy (external skin and oral mucosal irradiation and intravenous laser blood irradiation procedures) showed that obvious microhemodynamic changes (a >0.8°C in-crease in the temperature of the irradiated surface) were observed in no more than 20% of cases; a visible reaction was absent in the other cases.

The efficacy and safety of the multicomponent complex Nefradoz that was used to treat patients with nephrolithiasis after extracorporeal shock-wave lithotripsy and as a drug of lithokinetic therapy in patients with a stone in the lower third of the ureter were investigated. The treatment of 75 patients with nephrolithiasis was analyzed. Incorporation of nefradoz into a complex of treatment for patients with nephrolithiasis enhances the efficiency of lithokinetic therapy and favors the more favorable course in the postoperative period after extracorporeal shock-wave lithotripsy.

The paper shows the high antisecretory potential of the esomeprazole generic drug Emanera® (KRKA) in patients with acid-related diseases (ulcer disease and erosive gastroduodenitis) during long-term (48-hour) monitoring of intragastric pH. No cases of primary resistance have been found. Concluslon. Emanera® at a dose of 40 mg is suitable for use in acid-related diseases including situation with high demands on the level of suppression of acidity (optimized Helicobacter Pylori eradication, erosive GERD and Barrett's esophagus, extraesophageal manifestations of GERD, etc.).

The efficiency of long-term (12-month) treatment with a fixed-dose combination of perindopril and amlodipine (Prestans, Servier) was studied in 68 patients with chronic obstructive pulmonary disease and arterial hypertension. This treatment was shown not only to produce a stable antihypertensive effect, to decrease left ventricular mass, and to considerably improve left ventricular diastolic function, but also to significantly lower pulmonary artery systolic pressure and to reduce the sizes of the right ventricle, the echographic signs of its systolic and diastolic dysfunction, the clinical and spirographic signs of bronchial obstructive syndrome, and the level of proinflammatory cytokines (tumor necrosis factor-α and interleukin-6).

The paper shows the high efficiency of intravaginal autolymphocytotherapy for infertile women included in an in vitro fertilization program.

The paper gives the results of rehabilitation in cardiac surgery patients according to the authors’ procedure.

The aim of present investigation is research of efficacy of different hypotensive medicines in primary and secondary prevention of vascular diseases of brain and heart.

The use of minimally manipulated cellular products in regenerative medicine and plastic surgery will open up fresh opportunities in the development of personalized medicine. Large plastic surgery clinics are mostly adapted to this type of medical care owing to the qualification of the staff and the possibilities of setting up laboratories to work with cellular products.

The intelligent systems in medicine are reviewed in the article; particular attention is paid to the principles of building intelligent support system for doctor's decisions and system of distant education in dermatovenerology.