Vol 29, No 9 (2018)

The paper presents the issues of neuroplasticity in patients with diabetes mellitus and in experimental models, as well as the effect of insulin, the variability of glycemia, and the level of brain-derived neurotrophic factor on plasticity.

The brain memory mechanism is a network of cyclic neural circuits (CNCs). When there is insufficient γ-aminobutyric acid secretion in the brain, many CNCs are switched off from the memory mechanism, which causes cognitive dysfunction. This is one of the causes of memory impairment in AlzheimePs disease and senile dementia of the Alzheimer type.

The results of the Crystal study have shown the high prevalence of cognitive impairment (CI) in people aged over 65 years. About half of CI cases may be reversible and associated with concomitant depression.

The paper provides an overview of the use of metabolic drug cocarnit in patients with diabetic polyneuropathy (DPNP). It considers the pathogenesis of DPNP in light of the development of oxidative stress in diabetes mellitus and the effect of medicines that are contained in cocarnit on its manifestation.

The paper considers age-related and situational depression as a special condition in the anti-aging medicine clinic. It is important that age-related and situational depression is the background for the development of anxiety-depressive syndrome as an individual nosological entity that requires the correction corresponding to the patients status, as well as the follow-up by a psychotherapist or a psychiatrist. The paper presents the questionnaires and scales, which can be used in the anti-aging medicine clinic if anxiety and depression are suspected.

Diabetic peripheral neuropathy is the most common complication associated with diabetes mellitus, which is represented by heterogeneous conditions that differ in the site of a lesion in the nervous system lesion and manifestations. In his/her practice, a physician can encounter neuropathy induced by rapid improvements of glycemic control in individuals with long-term hyperglycemia. The importance of achieving glycemia as close to physiological range is undisputed, but the risk of severe pain syndrome in the lower extremities in the presence of relative hypoglycemia necessitates an individual approach in compliance with the tactics of gradual compensation of carbohydrate metabolism.

The authors have estimated the dynamics of cognitive impairment in hypertensive patients with risk factors for chronic kidney disease at the stage of sanatoriumresort stage.

The paper presents pharmacological agents, the use of which is indicated in sports practice to improve the body's overall tolerance to high physical activity, to intensify recovery processes, and to prevent the negative effects of inadequate physical stress on the body. The biomedical support of a training process in young hockey players should ensure that pharmacological agents are reasonably used.

The paper considers the efficacy of running impulse magnetic field therapy with an ALMAG apparatus in the combination treatment of patients with lower extremity varicose vein disease.

Current studies indicate comorbidity of psoriasis and various hepatobiliary disorders. Concurrence of psoriasis and non-alcoholic fatty liver disease is most frequently encountered. The paper describes common components in the pathogenesis of these diseases, which is one of the reasons for incorporating hepatoprotective agents in the combination therapy of psoriasis. The authors investigation demonstrates the advantage of a drug containing essential phospholipids and glycyrrhizic acid over conventional therapy with hepatoprotective drugs.