Quantum-chemical calculation as a method of theoretical prediction of the physico-chemical interaction of intranasal gel components
- Authors: Kovtun E.V.1, Pogrebnyak L.V.1, Stepanova E.F.1, Pogrebnyak A.V.1, Bokov D.O.2, Dadou Monеb M.Y.1
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Affiliations:
- Рyatigorsk Medical and Pharmaceutical Institute-branch of the Federal State Budgetary Educational Institution of the Ministry of Health of the Russian Federation
- A.P. Nelyubin Institute of Pharmacy, Sechenov First Moscow State Medical University
- Issue: Vol 71, No 8 (2022)
- Pages: 34-39
- Section: Technology of medicines
- URL: https://journals.eco-vector.com/0367-3014/article/view/317445
- DOI: https://doi.org/10.29296/25419218-2022-08-05
- ID: 317445
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Abstract
Introduction. An important area of pharmaceutical research is the creation of new, as well as the improvement of existing available dosage forms, using already known medicinal substances as active substances. Currently, the issues of developing drugs that activate the integrative properties and functions of the brain, as well as increase the body's resistance to aggressive influences, are relevant. A group of drugs that regulate such conditions are nootropics, namely piracetam and its analogues. The advantages of nasal dosage forms for realizing this are obvious. This is both high bioavailability and the possibility of systemic action of medicinal substances. The speed of development of the effect, as a result of the active absorption of medicinal substances that are cleaved in the gastrointestinal tract.
Objectives: selection and theoretical justification of an intranasal dosage form containing piracetam as an active ingredient and several different excipients.
Material and methods. When creating an intranasal dosage form with a nootropic effect, various research methods were used: technological, biopharmaceutical. And also, methods of molecular mechanics and quantum chemistry.
Results. Theoretical and experimental studies on the choice of excipients for intranasal dosage form have been carried out.
Conclusion. The conducted studies prove the feasibility of developing a dosage form technology – an intranasal gel with piracetam, which has nootropic activity.
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About the authors
Elena Vladimirovna Kovtun
Рyatigorsk Medical and Pharmaceutical Institute-branch of the Federal State Budgetary Educational Institution of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: elena.f.73@mail.ru
ORCID iD: 0000-0003-3437-760X
PhD in pharmaceutical sciences, associate professor of the Department of Pharmaceutical Technology with a Course in Medical Biotechnology, Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University of the Ministry of Health of Russia
Kalinin Avenue, 11, Pyatigorsk, 357532, Russian FederationLyudmila Vladimirovna Pogrebnyak
Рyatigorsk Medical and Pharmaceutical Institute-branch of the Federal State Budgetary Educational Institution of the Ministry of Health of the Russian Federation
Email: lyupin@yandex.ru
ORCID iD: 0000-0002-3683-9196
PhD in pharmaceutical sciences, Associate Professor of the Department of Pharmaceutical Technology with a Course in Medical Biotechnology, Pyatigorsk Medical and Pharmaceutical Institute – branch of the Federal State Budgetary Educational Institution of Higher Education "VolgGMU" of the Ministry of Health of Russia
Kalinin Avenue, 11, Pyatigorsk, 357532, Russian FederationEleonora Fedorovna Stepanova
Рyatigorsk Medical and Pharmaceutical Institute-branch of the Federal State Budgetary Educational Institution of the Ministry of Health of the Russian Federation
Email: efstepanova@yandex.ru
ORCID iD: 0000-0002-4082-3330
Doctor of Pharmaceutical Sciences, Professor, Professor of the Department of Pharmaceutical Technology with the Course of Medical Biotechnology, Pyatigorsk Medical and Pharmaceutical Institute – branch of the VolgGMU of the Ministry of Health of Russia
Kalinin Avenue, 11, Pyatigorsk, 357532, Russian FederationAndrey Vladimirovich Pogrebnyak
Рyatigorsk Medical and Pharmaceutical Institute-branch of the Federal State Budgetary Educational Institution of the Ministry of Health of the Russian Federation
Email: pspa2007@yandex.ru
ORCID iD: 0000-0002-6430-8018
Doctor of Chemistry, Professor of the Department of Inorganic, Physical and Colloidal Chemistry, Pyatigorsk Medical and Pharmaceutical Institute – branch of the Federal State Budgetary Educational Institution of Higher Education “VolgGMU” of the Ministry of Health of Russia
Kalinin Avenue, 11, Pyatigorsk, 357532, Russian FederationDmitry Olegovich Bokov
A.P. Nelyubin Institute of Pharmacy, Sechenov First Moscow State Medical University
Email: bokov_d_o@staff.sechenov.ru
ORCID iD: 0000-0003-2968-2466
PhD in pharmaceutical sciences, associate professor, associate professor of the Pharmaceutical Natural Sciences Department at Institute of Pharmacy named after A.P. Nelyubin, Sechenov University; researcher of laboratory of chemistry of food products at the Federal State Budgetary Scientific Institution “Federal Research Center of Nutrition and Biotechnology”
8 Trubetskaya St., bldg. 2, Moscow, 119991, Russian FederationM. Y. Dadou Monеb
Рyatigorsk Medical and Pharmaceutical Institute-branch of the Federal State Budgetary Educational Institution of the Ministry of Health of the Russian Federation
Email: Moneb-rm@hotmail.com
ORCID iD: 0000-0002-4229-3716
postgraduate of the Department of Pharmaceutical Technology with a Course in Medical Biotechnology, Pyatigorsk Medical and Pharmaceutical Institute – branch of the Federal State Budgetary Educational Institution of Higher Education "VolgGMU" of the Ministry of Health of Russia
Kalinin Avenue, 11, Pyatigorsk, 357532, Russian FederationReferences
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