Use of PlateletRich Autoplasma in Complex Therapy of Knee Osteoarthrosis

Full Text


Efficacy of platelet-rich autoplasma (PRA) in treatment of osteoarthrosis was evaluated. Prospective study included 120 patients (83 females, 37 males, mean age 52.8±4.5 years) with clinical and roentgenologic diagnosis of II-IV stage osteoarthrosis by Kellgren-Lawrence classification. The patients from the main group (n=60) were on courses of PRA intraarticular injections (3 injections with 1-2 weeks interval). In the control group the patients received nonsteroidal anti-inflammatory drugs (NSAIDs) and periodically injections of glucocorticoids when indicated. Results were assessed by the verbal efficacy scale, Lequesne index and the pain visual analog scale. Follow up period made up 6 months. Use of PRA enabled to eliminate pain syndrome and improve knee joint function without adverse effects. In 6 months the number of patients who noted the efficacy of treatment was 31% higher in the main group than in the control one. The obtained results allow recommending PRA use for knee osteoarthrosis treatment as an alternative to NSAIDs especially in contraindications to the latter.

Full Text

Restricted Access

About the authors

A. I Gorbatenko

Rostov State Medical University

N. O Kostyanaya

“Pathoanatomical bureau”, Rostov-on-Don


  1. Бадокин В.В. Современные аспекты патогенетической терапии остеоартроза. Медицинский совет. 2013; 12: 77-83.
  2. Алексеева Л.И., Верткин А.Л., Иванов В.С. Остеоартроз в практике врача-терапевта. Русский медицинский журнал. 2008; 16 (7): 476-80.
  3. Алексеева Л.И. Современные представления о диагностике и лечении остеоартроза. Русский медицинский журнал. Ревматология. 2000; 9: 81-8.
  4. Holt H.L., Katz J.N., Reichmann W.M., Gerlovin H., Wright E.A., Hunter D.J. et al. Forecasting the burden of advanced knee osteoarthritis over a 10-year period in a cohort of 60-64 year-old US adults. Osteoarthritis Cartilage. 2011; 19 (1): 44-50.
  5. Bruyere O., Cooper C., Pelletier J.P. An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: A report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin. Arthritis Rheum. 2014; 44 (3): 253-63.
  6. Миронов С.П. Очкуренко А.А., Кесян Г.А. Савельев С.Н., Аркадьев А.А., Збараг Н.Н. Эффективность применения аутологичных факторов роста при повреждениях и заболеваниях костно-мышечной системы. Вестник травматологии и ортопедии им. Н.Н. Приорова. 2014; 1: 86-93.
  7. Haleem A.M., Singergy A.A., Sabry D., Atta H.M., Rashed L.A., Chu C.R. et al. The Clinical use of human culture-expanded autologous bone marrow mesenchymal stem cells transplanted on platelet-rich fibrin glue in the treatment of articular cartilage defects: A pilot study and preliminary results. Cartilage. 2010; 1 (4): 253-61.
  8. Castricini R., Longo U.G., De Benedetto M.Platelet-rich plasma augmentation for arthroscopic rotator cuff repair. A randomized controlled trial. Am. J. Sports. Med. 2011; 39: 258-65.
  9. Маланин Д.А., Новочадов В.В., Демкин С.А., Демещенко М.В., Данилов Д.И. Обогащенная тромбоцитами аутологичная плазма в лечении пациентов с гонартрозом 3 стадии. Травматология и ортопедия России. 2014; 3 (73): 57-65.
  10. Görmeli G., Görmeli C.A., Ataoglu B., Çolak C., Aslantürk O., Ertem K. Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with earlyosteoarthritis: a randomized, double-blind, placebo-controlled trial. Knee Surg. Sports. Traumatol. Arthrosc. 2015; 2: 1-8.
  11. Filardo G., Di Matteo B., Di Martino A., Merli M.L., Cenacchi A., Fornasari P., Marcacci M., Kon E. Platelet-rich plasma intra-articular knee injections show no superiority versus viscosupplementation: A randomized controlled trial. Am. J. Sports Med. 2015; 43 (7): 1575-82.
  12. Khoshbin A., Leroux T., Wasserstein D., Marks P., Theodoropoulos J., Ogilvie-Harris D., Gandhi R., Takhar K., Lum G., Chahal J. The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis. Arthroscopy. 2013; 29 (12): 2037-48.
  13. Forogh B., Mianehsaz E., Shoaee S., Ahadi T., Raissi G.R., Sajadi S. Effect of single injection of Platelet-rich plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial. J. Sports Med. Phys. Fitness. 2015; 14 [Epub ahead of print].
  14. Detterline A.J., Goldberg S., Bach B.R. Jr, Cole B.J. Treatment options for articular cartilage defects of the knee. Orthop. Nurs. 2005; 24: 361.
  15. Емелин А.Л., Ахтямов И.Ф. Клиническая эффективность тромбоцитарной аутоплазмы при лечении остеоартрозов. Вестник современной клинической медицины. 2013; 6 (1): 26-9.
  16. Campbell K.A., Saltzman B.M., Mascarenhas R., Khair M.M., Verma N.N., Bach B.R.Jr, Cole B.J. Does intra-articular Platelet-Rich Plasma injection provide clinically superior outcomes compared with other therapies in the treatment of knee osteoarthritis? A systematic review of overlapping meta-analyses. Arthroscopy. 2015; 31 (11): 2213-21.
  17. Patel S., Dhillon M.S., Aggarwal S., Marwaha N., Jain A. Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: а prospective, double-blind, randomized trial. Am. J. Sports Med. 2013; 41: 356-64.
  18. Широкова Л.Ю., Носков С.М., Бахтиарова Т.И., Снегирева А.В., Носкова Т.С. Локальная терапия гонартроза аутологичной, обогащенной тромбоцитами плазмой. Современные технологии в медицине. 2012; 1: 97-100.



Abstract: 106


Article Metrics

Metrics Loading ...



  • There are currently no refbacks.

Copyright (c) 2016 Eco-Vector

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies