Influence of Bisphosphonates within Biocomposites upon Bone Formation and Bone Mineralization

Abstract

Effect of various nitrogen containing bisphosphonates (ibandronic acid - Bonviva, zolendronic acid - Aklasta, alendronate sodium - Fosamax) within biocomposite materials upon the process of bone formation and bone mineral density in the zone of surgical intervention (bone defect formation) and segment as a whole (tibia) at local application was studied in animal experiment (60 rats). Morphologic study showed that bisphosphonates did not depress bone formation but even provided its higher intensity as compared to the control group (p=0.045). Analysis of the influence of study bisphosphonated upon bone formation showed reliable advantage (p<0.05) of zolendronic acid. Contrary to control group intensive bone formation was accompanied by reliable BMD increase both in zone of intervention and in segment as a whole. That confirmed the positive influence upon bone tissue remodeling

References

  1. Колондаев А.Ф., Родионова С.С., Ерешкин Р.О. Эффективность применения алендроната в сочетании с альфакальцидолом у больных с остеопорозом //Проблемы остеопороза в травматологии и ортопедии: Тезисы конф. с междунар. участием, 3-й. - М., 2006. - С. 98-99.
  2. Лекишвили М.В., Панасюк А.Ф. Новые биопластические материалы в реконструктивной хирургии //Вестн. РАМН. - 2008. - N 9. - С. 33-36.
  3. Родионова С.С., Колондаев А.Ф. Болезнь Педжета. - ГЭОТАР-Медиа. Серия: Актуальные вопросы медицины. - М., 2008. - С. 41-43.
  4. Родионова С.С., Тургумбаев Т.Н. Применение алендроната в послеоперационном периоде для профилактики асептической нестабильности эндопротеза тазобедренного сустава //Вестн. травматол. ортопед. - 2009. - N 3. - С. 36-44.
  5. Родионова С.С., Торгашин А.Н., Подурец К.М. и др. Рефракционная интроскопия и двухэнергетическая рентгеновская абсорбциометрия в оценке костеобразования //Вестн. травматол. ортопед. - 2010. - N 3. - С. 34-42.
  6. Шумский А.А., Тургумбаев Т.Н. Системная потеря костной ткани у пациентов с асептическим некрозом головки бедренной кости. //Эндопротезирование крупных суставов: Всерос. конф. - М., 2009. - С. 113.
  7. Astrand J., Aspenberg R. Reduction of instability-induced bone resorption using bisphosphonates: high doses are needed in rats //Acta Orthop. Scand. - 2002. - Vol. 73. - P. 24-30.
  8. Aspenberg P., Astrand J. Bone allografts pretreated with a bisphosphonate are not resorbed //Acta Orthop. Scand. - 2002. - Vol 73. - P. 20-23.
  9. Board T.N., Rooey P., Kearney J.N. Impaction allografting in revision total hip replacement //J. Bone Jt Surg. - 2006. - Vol. 88B. - P. 852-857.
  10. Boissier S., Ferrers M., Peyruchaud O. et al. Bisphosphonates inhibit breast and prostata carcinoma cell invasion an early event in the formation of bone metastase //Cancer Res. - 2000. - Vol. 60. - P. 2949-2954.
  11. Bostrom M.P., Seigerman D.A. The clinical use of allografts, demineralized bone matrices, synthetic bone graft substitutes and osteoinductive growth factors: а survey study //HSS J. - 2005. - N 1. - P. 9-18.
  12. Burkhart K.J., Rommens P.M. Intramedullary application of bone morphogenetic protein in the management of a major bone defect after an Ilizarov procedure //J. Bone Jt Surg. - 2008. - Vol. 90B. - P. 806-809.
  13. Carfi-Pavia F., Turturici G., Geraci F. et al. Porous poly (L-lactic acid) scaffolds are optimal substrates for internal colonization by A6 mesoangioblasts and immunocytochemical analyses //J. Biosci. - 2009. - Vol. 34, N 6. - P. 873-879.
  14. Dombrecht E.J., Schuerwegh A.J., Bridts C.H. et al. Effect of bisphosphonates on nitric oxide production by inflammatory activated chondrocytes //Clin. Exper. Rheumatol. - 2007. - Vol. 25. - P. 817-822.
  15. Greiner S.H., Wildemann B., Back D.A. et al. Local application of zoledronic acid incorporated in a poly(D, L-lactide)-coated implant accelerates fracture healing in rats //Acta Orthop. Scand. - 2008. - Vol. 79, N 5. - P. 717-725.
  16. Idris A.I., Rojas J., Greig I.R. et al. Aminophosphonetes cause osteoblast apoptosis end inhibit bone nodule formation in vitro //Calcif. Tissue Int. - 2008. - Vol. 82. - P. 191-201.
  17. Jakobsen T., Baas J., Bechtold J.E. et al. Soaking morselized allograft in bisphosphonate can impair implant fixation //Clin. Orthop. - 2007. - N 463. - P. 195-201.
  18. Karrholm J., Malchau H., Snorrason F., Herberts P. Micromotion of femoral stems in total hip arthroplasty: a randomized study of cemented, hydroxyapatite-coated, and porous-coated stems with roentgen stereophotogrammetric analysis //J. Bone Jt Surg. - 1994. - Vol. 76. - P. 692-705.
  19. Kesteris U., Aspenberg P. Rinsing morcellised bone grafts with bisphosphonate solution prevents their resorption: a prospective randowised double-blinded study //J. Bone Jt Surg. - 2006. - Vol. 88. - P. 993-996.
  20. Kim M.K., Niyibizi C. Interaction of TGF-beta1 and rhBMP-2 on human bone marrow stromal cells cultured in collagen gel matrix //Yonsei Med. J. - 2001. - Vol. 42, N 3. - P. 338-344.
  21. Kwak H.B., Kim J.Y., Kim K.J. et al. Risedronate directly inhibits osteoclast differentiation and inflammatory bone loss biol //Pharm. Bull. - 2009. - Vol. 32, N 7. - P. 1193-1198.
  22. Matos М.А., Tannuri U., Guarniero R. The effect of zoledronate during bone healing //J. Orthop. Traum. - 2010. - Vol. 11. - P. 7-12.
  23. Mont М.А., Seyler Т.М., Рlate J.F. et al. Uncemented total hip arthroplasty in young adults with osteonecrosis of the femoral head: a comparative study //J. Bone Jt Surg. - 2006. - Vol. 88A. - P. 104-109.
  24. Nancollas G.H., Tang R., Phipps R.J. et al. Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite //Bone. - 2006. - Vol. 38, N 5. - P. 617-627.
  25. Nishioka Т. Alendronate inhibits periprosthetic bone loss around uncemented femoral components //J. Bone Miner. Metab. - 2007. - Vol. 25. - P. 179-183.
  26. Ochs B.G., Schmid U., Rieth J. et al. Acetabular bone reconstruction in revision arthroplasty //J. Bone Jt Surg. - 2008. - Vol. 90B. - P. 1164-1171.
  27. Tuin A., Kluijtmans S.G., Bouwstra J.B. et al. Recombinant gelatin microspheres: novel formulations for tissue repair? //Tissue Eng. Part A. - 2010. - Vol. 16, N 6. - P. 1811-1821.
  28. Van Haaren E.H., Heyligers I.C., Alexander F.G., Wuisman P.I. High rate of failure of impaction grafting in large acetabular defects //J. Bone Jt Surg. - 2007. - Vol. 89B. - P. 296-300.
  29. Yanling J., Mehta C.K. et al. Bacteria induce osteoclastogenesis via an osteoblast-independent pathway //Infect. Immun. - 2002. - Vol. 70, N 6. - P. 3143-3148.
  30. Zhou S., Yates K.E., Eid K., Glowacki J. Demineralized bone promotes chondrocyte or osteoblast differentiation of human marrow stromal cells cultured in collagen sponges //Cell Tissue Bank. - 2005. - Vol. 6, N 1. - P. 33-44.

Copyright (c) 2011 Eco-Vector



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies