The phase diagram of the binary medicinal condensed system «Ketoprofen - Phenylbutazone»; anti-inflammatory activity of the binary eutectic system
- Authors: Seryakova A.N1, Tkachenko M.L1, Moschenskyi Y.V2
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Affiliations:
- Samara State Medical University
- Samara State Technical University
- Issue: Vol 22, No 12 (2019)
- Pages: 23-28
- Section: Articles
- URL: https://journals.eco-vector.com/1560-9596/article/view/112700
- DOI: https://doi.org/10.29296/25877313-2019-12-03
- ID: 112700
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Abstract
The data of phase equilibria of the condensed system «Ketoprofen - Phenylbutazone » are represented according to the results of measurements by the method of the differential scanning calorimetry (DSC) in the heating mode. It is established that the eutectic system reters to the eutectic systems with restricted (partial) mutual solubility in the solid state. Congruent equilibrium for this system is implemented at a ratio of 60:40% mol. (55,3:44,7% of mass.) of Ketoprofen and Phenylbutazone respectively. Melting point of the eutectic structure is 68 °C. Data shows the phase diagram of a system melting state. Preclinical tests of antiinflammatory activity were carried out on model of acute exudative inflammation (carrageenan edema of rats paw) on white outbred rats in comparative option with the use of: substances of Phenylbutazone, substance of Ketoprofen, mix of Phenylbutazone and Ketoprofen in the ratio 1:1 mol. and the eutectic system «Ketoprofen - Phenylbutazone». The results of experiments showed that the anti-exudative and antiinflammatory activity of the eutectic structure is twice higher than activities of individual components and their mix 1:1 mol. in comparable doses.
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About the authors
A. N Seryakova
Samara State Medical University
Email: seryakova_annet@mail.ru
Assistant, Department of Chemistry of Pharmaceutical Faculty
M. L Tkachenko
Samara State Medical University
Email: tka-mikhail@yandex.ru
Ph.D. (Chem.), Associate Professor, Department of chemistry of Pharmaceutical Faculty
Y. V Moschenskyi
Samara State Technical University
Email: yvmos@yandex.ru
Dr.Sc. (Chem.), Professor, Head of Department of Radio Engineering Devices
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