MULTICOMPONENT MEDICINAL PREPARATIONS: ADVANTAGES OF THEIR USE IN CLINICAL PRACTICE

The prospects of the use of multicomponent preparations in clinical practice are discussed on the base of the analysis of formularies. Today, many diseases are caused by stress, improper lifestyles associated with hypodynamie, impaired nutrition, and environmental distress. In this situation, it is necessary to regulate pharmacotherapy with complex drugs at the systemic level, which provides correction along the hierarchical ladder of life process management, mobilization of internal reserves for maintaining health, interfacing the action of the ingredients of the complex with the functional systems of the patient. In folk medicine of many countries, traditional eastern medicine, for thousands of years, multi-component (complex, combined, complex) drugs have been used, containing several ingredients, two or more active pharmacological substances. The inclusion of a number of medicinal components in one ready-made dosage form creates great amenities for the patient, eliminating the need to take many separate drugs, observing the order of their use, and experiencing inconvenience in the treatment and prevention of the disease. From the point of view of evidence-based medicine, they have withstood millennial trials, they have laid down centuries of experience in their successful use, and today, it is, multicomponent drugs of traditional medicine that are most interesting for research. The expressed effectiveness of the combined preparation is due to potentiation of the action of ingredients with unidirectional activity, but with different mechanisms. By reducing the proportion of components in the complex, the risk of undesirable effects when taken is reduced. Small doses of the components of the complex preparation allow modulating the natural processes of health restoration, accompanying the action of the main substances and creating conditions for the manifestation of the activity of the accompanying elements of the complex. The studies have shown that the complex drugs have a number of advantages: ease of use; drug potentiation; risk reduction of side effects; costs reduction; system effect of the complex as pharmacotherapeutic system. The emphasis is laid on the traditional combined remedies as their efficacy and safety have been proved for thousands of years and they are of great interest at present time.

multicomponent preparations, one-component preparations, efficacy and safety, advantages of complex remedies, pharmacotherapeutical system