STUDY OF THE ANTI-DIABETIC ACTIVITY OF HELICHRYSUM THIANSCHANICUM REGEL. IN ALLOXAN HYDRATE DIABETES MODEL


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Abstract

Relevance. The limited herbal medicines list is usedto prevent and treat the diabetes mellitus at present. The prospective raw material for such investigations is the Helichrysum thianschanicum Regel., the medicinal plant that widely grows in Tajikistan. The aim of the study was to investigate the antidiabetic properties of the Helichrysum thianschanicum Regel, flowers and leaves infusion in experimental diabetes model. Material and methods. We used 36 white nonlinear rats of both sexes weighing 180-220 grams. Flowers and leaves of the Helichrysum thianschanicum Regel, were collected in the Darvaz region (2400m above sea level) - the Republic of Tajikistan in July-August 2016-2017. The study of the antidiabetic activity was performed on the alloxan diabetes model in rats. Results. It was found that the Helichrysum thianschanicum Regel, flowers and leaves infusion has a significant antidiabetic and metabolism-corrective effect, improving the functional parameters of the kidneys and liver, has a antiatherogenic activity. Conclusion. The results show that the Helichrysum thianschanicum Regel, flowers and leaves infusion has potential for preclinical research and antidiabetic drug development.

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About the authors

M. U Sharofova

Institute of Avicenna's Medicine and Pharmacology; Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan

Email: mijgona72@mail.ru
Ph.D., Director of Institute of Avicenna's Medicine and Pharmacology; Head of the Laboratory, Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan Dushanbe

Sh. S Sagdieva

Institute of Avicenna's Medicine and Pharmacology; Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan

Email: shoistass@mail.ru
Ph.D. (Med.), Senior Research Scientist, Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan; Institute of Avicenna's Medicine and Pharmacology Dushanbe

S. J Yusufi

Avicenna Tajik State Medical University

Email: salomudin@mail.ru
Doctor of Pharmaceutical Sciences, Professor, Academician of the Academy of Medical Sciences of the Ministry of Health and Social Protection of the Population of the Republic of Tajikistan, Department of Pharmacognosy and Fundamentals of Pharmacy Economics, Avicenna Tajik State Medical University Dushanbe

S. R Numonov

Institute of Avicenna's Medicine and Pharmacology; Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan

Email: sodikjon82@gmail.com
Ph.D. (Chem.), Senior Research Scientist, Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan; Institute of Avicenna's Medicine and Pharmacology Dushanbe

R. U Rahmonov

Institute of Avicenna's Medicine and Pharmacology; Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan

Email: rahmon777@list.ru
Senior Research Scientist, Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan; Institute of Avicenna's Medicine and Pharmacology Dushanbe

E. V Ferubko

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Email: ferubko@vilarnii.ru
Ph.D. (Med.), Head of Department of Experimental Pharmacology Moscow

I. A Lupanova

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Email: lupanova@vilarnii.ru
Ph.D. (Biol.), Head of the Center for Preclinical Research Moscow

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