STUDY OF THE ANTI-DIABETIC ACTIVITY OF HELICHRYSUM THIANSCHANICUM REGEL. IN ALLOXAN HYDRATE DIABETES MODEL


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Relevance. The limited herbal medicines list is usedto prevent and treat the diabetes mellitus at present. The prospective raw material for such investigations is the Helichrysum thianschanicum Regel., the medicinal plant that widely grows in Tajikistan. The aim of the study was to investigate the antidiabetic properties of the Helichrysum thianschanicum Regel, flowers and leaves infusion in experimental diabetes model. Material and methods. We used 36 white nonlinear rats of both sexes weighing 180-220 grams. Flowers and leaves of the Helichrysum thianschanicum Regel, were collected in the Darvaz region (2400m above sea level) - the Republic of Tajikistan in July-August 2016-2017. The study of the antidiabetic activity was performed on the alloxan diabetes model in rats. Results. It was found that the Helichrysum thianschanicum Regel, flowers and leaves infusion has a significant antidiabetic and metabolism-corrective effect, improving the functional parameters of the kidneys and liver, has a antiatherogenic activity. Conclusion. The results show that the Helichrysum thianschanicum Regel, flowers and leaves infusion has potential for preclinical research and antidiabetic drug development.

全文:

受限制的访问

作者简介

M. Sharofova

Institute of Avicenna's Medicine and Pharmacology; Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan

Email: mijgona72@mail.ru
Ph.D., Director of Institute of Avicenna's Medicine and Pharmacology; Head of the Laboratory, Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan Dushanbe

Sh. Sagdieva

Institute of Avicenna's Medicine and Pharmacology; Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan

Email: shoistass@mail.ru
Ph.D. (Med.), Senior Research Scientist, Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan; Institute of Avicenna's Medicine and Pharmacology Dushanbe

S. Yusufi

Avicenna Tajik State Medical University

Email: salomudin@mail.ru
Doctor of Pharmaceutical Sciences, Professor, Academician of the Academy of Medical Sciences of the Ministry of Health and Social Protection of the Population of the Republic of Tajikistan, Department of Pharmacognosy and Fundamentals of Pharmacy Economics, Avicenna Tajik State Medical University Dushanbe

S. Numonov

Institute of Avicenna's Medicine and Pharmacology; Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan

Email: sodikjon82@gmail.com
Ph.D. (Chem.), Senior Research Scientist, Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan; Institute of Avicenna's Medicine and Pharmacology Dushanbe

R. Rahmonov

Institute of Avicenna's Medicine and Pharmacology; Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan

Email: rahmon777@list.ru
Senior Research Scientist, Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan; Institute of Avicenna's Medicine and Pharmacology Dushanbe

E. Ferubko

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Email: ferubko@vilarnii.ru
Ph.D. (Med.), Head of Department of Experimental Pharmacology Moscow

I. Lupanova

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Email: lupanova@vilarnii.ru
Ph.D. (Biol.), Head of the Center for Preclinical Research Moscow

参考

  1. Асфандиярова Н.С. Смертность при сахарном диабете 2 типа. Сахарный диабет. 2015; 18(4): 12-21.
  2. Балаболкин М.И. Диабетология. М.: Медицина. 2002. 672 с.
  3. Самойлова Ю.Г., Ротканк М.А., Жукова Н.Г., Матвеева М.В., Толмачев И.В., Кудлай Д.А. Вариабельность гликемии у пациентов с сахарным диабетом 1-го типа: связь с когнитивной дисфункцией и данными магнитнорезонансных методов исследования. Проблемы Эндокринологии 2018; 64(5): 2. 86-291.
  4. Самойлова Ю.Г., Ротканк М.А., Жукова Н.Г., Матвеева М.В., Толмачев И.В., Кудлай Д.А. Маркеры когнитивных нарушений и вариабельность гликемии у пациентов с сахарным диабетом 1-го типа. Журнал неврологии и психиатрии им. С.С. Корсакова. 2018; 118(4): 48-51.
  5. Дергачева Ж.М., Гурина Н.С. Лекарственные растения, используемые в лечении сахарного диабета. Рецепт. 2012;3(83): 84-99.
  6. Шарофова М.У., Сагдиева Ш.С., Юсуфи С.Дж., Нуъмонов С.Р. Изучение антидиабетических свойств бессмертника тяньшаньского при экспериментально вызванной инсулинорезистентности. От растения до лекарственного препарата. Материалы международной научной конференции. М. 2020: 420-425.
  7. Lytvyn Y. Uric Acidasa Biomarker and a Therapeutic Targetin Diabetes. Cherney Canadian Journal of Diabetes. 2015; 39(3): 239-246.
  8. Abu-Asab M., Amri H., Micozzi M. Avicenna’s medicine: a new translation of the 11th-century canon with practical applications for integrative health care. Rochester. Vermont: Healing Art Press.2013: 1-462.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Russkiy Vrach Publishing House, 2021