Determination of residual organic solvents in a new cardioprotective compound by gas chromatography
- Authors: Kompantseva E.V1, Lutsenko D.N1, Larsky M.V1
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Affiliations:
- Pyatigorsk Medical and Pharmaceutical Institute - branch of the Volgograd State Medical University of the Ministry of Health of Russia
- Issue: Vol 24, No 10 (2021)
- Pages: 52-58
- Section: Articles
- URL: https://journals.eco-vector.com/1560-9596/article/view/112892
- DOI: https://doi.org/10.29296/25877313-2021-10-07
- ID: 112892
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Abstract
Relevance. Gas chromatography - a method that allows you to quickly and accurately conduct a qualitative and quantitative analysis of the components of various mixtures, as well as divide them into their component parts - is widely used in various industries, including pharmaceutical. The purpose of this study was to develop and validate a method for determining residual organic solvents in the substance of the biologically active compound (BAS) N-[2-[4-oxo-3(4h)-quinazolinyl]propionyl]-guanidine (VMA-13-15) by gas chromatography. Material and methods. The objects of the study were laboratory samples of BAS VMA-13-15 (series 2017, 2018 and 2019), as well as CO methanol (GSO 8461-2003) and diethyl ether (OST-84-2006-88) qualifications of the he. Results. A method for the determination of residual organic solvents in the BAS substance N-[2-[4-oxo-3(4h)-quinazolinyl]propionyl]-guanidine by gas chromatography has been developed. The method was validated according to the following indicators: specificity, linearity, correctness and precision. Conclusions. The method for determining the residual organic solvents of N-[2-[4-oxo-3(4h)-quinazoline]propionyl]-guanidine can be recommended for inclusion in the draft regulatory documentation.
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About the authors
E. V Kompantseva
Pyatigorsk Medical and Pharmaceutical Institute - branch of the Volgograd State Medical University of the Ministry of Health of RussiaDr.Sc. (Pharm.), Professor, Department of Pharmaceutical Chemistry Pyatigorsk, Russia
D. N Lutsenko
Pyatigorsk Medical and Pharmaceutical Institute - branch of the Volgograd State Medical University of the Ministry of Health of Russia
Email: lucenkodasha95@mail.ru
Post-graduate Student, Department of Pharmaceutical Chemistry Pyatigorsk, Russia
M. V Larsky
Pyatigorsk Medical and Pharmaceutical Institute - branch of the Volgograd State Medical University of the Ministry of Health of RussiaPh.D.(Pharm.), Head of the Department of Pharmaceutical Chemistry Pyatigorsk, Russia
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