Prediction of mechanisms of pharmacological action of a multicomponent herbal extract using the PASS online web resource on the example of the herb of chicoria
- Authors: Adamov G.V1, Saybel O.L1, Mizina P.G1
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Affiliations:
- All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
- Issue: Vol 24, No 12 (2021)
- Pages: 36-40
- Section: Articles
- URL: https://journals.eco-vector.com/1560-9596/article/view/112915
- DOI: https://doi.org/10.29296/25877313-2021-12-05
- ID: 112915
Cite item
Abstract
Prediction of the biological activity of chemical compounds before conducting biological analyzes is now a common practice. Preliminary screening using software and mathematical methods allows you to identify the most promising chemical compounds and thereby significantly save expended resources, including reducing the number of required laboratory animals. For the first time, the article proposes to use the prediction of pharmacological activity for total herbal preparations. For this, using the open platform PASS online, the pharmacological activity of phenolic acids of chicory was predicted, and the effects were identified that coincide for most of the selected compounds. This approach makes it possible to level the probabilistic nature of the assessment for each individual compound and to suggest synergistic interactions. According to the data obtained, hypolipidemic, immunostimulating and antibacterial effects are predicted for chicory.
Keywords
Full Text
About the authors
G. V Adamov
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: grig.adamov@mail.ru
Ph.D (Pharm.), Research Scientist
O. L Saybel
All-Russian Scientific Research Institute of Medicinal and Aromatic PlantsPh.D. (Pharm.)
P. G Mizina
All-Russian Scientific Research Institute of Medicinal and Aromatic PlantsDr.Sc. (Pharm.)
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