Evaluation of essential metal levels in subcutaneous and visceral adipose tissue samples from patients with morbid obesity: a pilot study


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Abstract

The objective of the study was to evaluate essential metal levels in subcutaneous and visceral adipose tissue samples from patients with morbid obesity. Adipose tissue samples were collected from 10 women with morbid obesity (BMI > 35) aged 30-50 y.o. Assessment of iron (Fe), copper (Cu), manganese (Mn), zinc (Zn), and selenium (Se) levels in adipose tissue samples was performed using inductively coupled plasma mass spectrometry. The obtained data demonstrate that iron and copper levels in visceral adipose tissue were 68% (p = 0,021) and 38% (p = 0,053) higher as compared to subcutaneous depot. No difference in tissue Mn, Se, and Zn levels were observed. The obtained values generally correspond to those reported in studies from Spain, Italy, and Lithuania. Correlation analysis demonstrated positive association between subcutaneous adipose tissue Fe, visceral adipose tissue Fe and Cu contents, and BMI values. Therefore, the obtained findings demonstrate heterogeneity of adipose tissue metal levels in patients with morbid obesity with predominant accumulation of Fe and Cu in visceral adipose tissue.

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About the authors

A. V Skalny

Sechenov University; RUDN University

Dr.Sc. (Med.), Professor

J. -S Chang

Taipei Medical University

PhD

V. N Nikolenko

Sechenov University

Dr.Sc. (Med.), Professor

S. -Y Huang

Taipei Medical University

PhD

D. A Zotkin

Sechenov University

Assistant

W. Wang

Taipei Medical University

PhD

A. A Tinkov

Sechenov University; RUDN University

Email: tinkov.a.a@gmail.com
Ph.D. (Med.); Associate Professor

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