Evaluation of dopaminergic activity of biologically active substances of verbena herb (verbena officinalis l.)
- Authors: Kulyak O.Y.1,2, Adamov G.V.1, Radimich A.I.1, Lupanova I.A.1, Saybel O.L.1
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Affiliations:
- All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
- Lomonosov Moscow State University
- Issue: Vol 26, No 4 (2023)
- Pages: 16-22
- Section: Pharmaceutical chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/340936
- DOI: https://doi.org/10.29296/25877313-2023-04-03
- ID: 340936
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Abstract
Relevance. The development of herbal medicines remains relevant today. Verbena officinalis L. has a spectrum of pharmacological activity, but our interest is manifested in its ability to treat amenorrhea and anovulation in hyperprolactinemia.
The purpose of the work was to study the dopaminergic activity of the extract, fractions and dominant substances of the verbena officinalis herb.
Materials and methods. The object of the study is the verbena officinalis herb, harvested experimentally in the field of the Botanical Garden of the Federal State Budgetary Scientific Institution VILAR in 2019.
Results. The dopaminergic activity of fractions of different polarity of herb verbena officinalis was assessed. The most active absorb ethyl acetate fraction, which includes: verbenalin and verbascoside. Verbenalin has been found to have a dopaminergic effect. Dopaminergic activity of the total extract, ethyl acetate fraction and inflammation verbenalin.
Conclusions. It is expedient to develop drugs for the treatment of amenorrhea and anovulation based on a total extract standardized for verbenalin.
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About the authors
O. Yu. Kulyak
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants; Lomonosov Moscow State University
Author for correspondence.
Email: Kulyak-Olesya@mail.ru
Ph.D (Pharm.), Research Scientist, Laboratory of Atomic-Molecular Bioregulation and Selection
Russian Federation, MoscowG. V. Adamov
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: Kulyak-Olesya@mail.ru
Ph.D (Pharm.), Senior Research Scientist, Laboratory of Atomic-Molecular Bioregulation and Selection
Russian Federation, MoscowA. I. Radimich
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: Kulyak-Olesya@mail.ru
Senior Research Scientist, Laboratory of Atomic-Molecular Bioregulation and Selection
Russian Federation, MoscowI. A. Lupanova
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: Kulyak-Olesya@mail.ru
Ph.D. (Biol.), Нead of the Center for Preclinical Studies
Russian Federation, MoscowO. L. Saybel
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: Kulyak-Olesya@mail.ru
Dr.Sc. (Pharm.), Head of the Center for Chemistry and Pharmaceutical Technology
Russian Federation, MoscowReferences
- Sambukova T.V., Ovchinnikov B.V., Ganapol'skij V.P., Jatmanov A.N., Shabanov P.D. Perspektivy ispol'zovanija fitopreparatov v sovremennoj farmakologii. Obzory po klinicheskoj farmakologii i lekarstvennoj terapii. 2017; 15(2): 56– 63.
- Kuljak O.Ju., Adamov G.V., Radimich A.I., Sajbel' O.L. Verbena lekarstvennaja (Verbena officinalis L.): obzor fitohimicheskih i farmakologicheskih issledovanij. Voprosy biologicheskoj, medicinskoj i farmacevticheskoj himii. 2019; 22(11): 47–56.
- Kubica P, Szopa A, Dominiak J, Luczkiewicz M, Ekiert H. Verbena officinalis (Common Vervain) A Review on the Investigations of This Medicinally Important Plant Species. Plan-ta Med. 2020; 86(17): 1241–1257. doi: 10.1055/a-1232-5758.
- Bekara A., Amazouz A., Douma T.B. Evaluating the Anti-depressant Effect of Verbena officinalis L. (Vervain) Aqueous Extract in Adult Rats. Basic Clin Neurosci. Jan- Feb; 2020; 11(1): 91–98. doi: 10.32598/bcn.11.1.3.
- Adamov G.V., Mel'nikov E.S., Lupanova I.A., Radimich A.I., Sajbel' O.L. Izuchenie himicheskogo sostava i dofaminergicheskoj aktivnosti plodov viteksa svjashhennogo (Vitex ag-nus-castus L.). Razrabotka i registracija. 2020; 9(3): 143–149.
- Pezzei C.K., Schönbichler S.A., Kirchler C.G., Schmelzer J., Hussain S., Huck-Pezzei V.A., Popp M., Krolitzek J., Bonn G.K., Huck C.W. Application of benchtop and portable near-infrared spectrometers for predicting the optimum harvest time of Verbena officinalis. Talanta. 2017; 1: 70–76.
- Molotkov A.S., Jarmolinskaja M.I. Znachenie prolaktina v patogeneze genital'nogo jendometrioza i vozmozhnosti terapii agonistami dofamina. Rossijskij vestnik akushera-ginekologa. 2015; 15(6): 42–47.
- Schönbichler S.A., Bittner L.K., Pallua J.D., Popp M., Abel G., Bonn G.K., Huck C.W. Simultaneous quantification of verbe-nalin and verbascoside in Verbena officinalis by ATR-IR and NIR spectroscopy. J Pharm Biomed Anal. 2013; 84: 97–102.
- Daneshforouz A., Nazemi S., Gholami O., Kafami M., Amin B. The cytotoxicity and apoptotic effects of verbascoside on breast cancer 4T1 cell line. BMC Pharmacol Toxicol. 2021; 22(1): 72.
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