Patterns of selenium, zinc and magnesium metabolism in patients with inflammatory arthropathies and polyarthritis

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Abstract

The objective of the present study was to assess the patterns of selenium, zinc, and magnesium metabolism in patients with inflammatory arthropathies (rheumatoid arthritis, gout, psoriatic arthritis) and polyarthritis through assessment of elemental levels in blood serum and hair.

Material and methods. During a study, patients with polyarthritis (n = 128) and inflammatory arthropathies including rheumatoid arthritis (n = 100), psoriatic arthritis (n = 32), gout (n = 135), as well as 110 healthy subjects representing the control group were examined. Assessment of selenium, zinc, and magnesium levels was performed using high-sensitive method of mass spectrometry with inductively-coupled plasma.

Results. The obtained data demonstrate that the level of Se in serum of patients with rheumatoid arthritis, psoriatic arthritis, gout, and polyarthritis was %, 11%, 5%, and 9% lower compared to healthy controls. Serum Zn concentrations in patients with rheumatoid arthritis, psoriatic arthritis, and polyarthritis were also lower than in the control group by 7%, 17%, and 7%, respectively. Hair analysis revealed a significant 20% decrease in selenium levels in polyarthritis patients compared to controls. Magnesium content in hair of patients with psoriatic arthritis and gout was 41% and 46% lower when compared to healthy examinees, respectively. At the same time, hair Zn levels in examinees suffering from rheumatoid arthritis, psoriatic arthritis, gout, and polyarthritis was 7%, 13%, 15%, and 12% lower than in the control group.

Conclusion. Therefore, the results of the study demonstrate a significant decline in systemic levels of selenium, zinc, and magnesium, all possessing antioxidant and anti-inflammatory effects, in patients with polyarthritis and inflammatory arthropathies, thus indicative of their potential involvement in pathogenesis of the studied diseases.

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About the authors

A. V. Skalny

I.M. Sechenov First Moscow State Medical University (Sechenov University); People's Friendship University of Russia

Email: skalny3@microelements.ru
ORCID iD: 0000-0001-7838-1366

Dr. Sc. (Med.), Professor, Director of the Center for Bioelementology and Human Ecology; Head of the Department of Medical Elementology

Russian Federation, Moscow; Moscow

T. V. Korobeinikova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: tatcvetk@yandex.ru

Ph.D. (Tech.), Head of the Laboratory of Molecular Dietetics

Russian Federation, Moscow

G. D. Morozova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: morozova0826@gmail.com
ORCID iD: 0000-0001-8600-902X

Laboratory Assistant of the Laboratory of Molecular Dietetics

Russian Federation, Moscow

X. Guo

Xi'an Jiaotong University

Email: guox@mail.xjtu.edu.cn
ORCID iD: 0000-0003-4413-5022

PhD, Professor, Director of the Key Laboratory of Trace Elements and Endemic Diseases

China, Xi'an

F. Zhang

Xi'an Jiaotong University

Email: fzhxjtu@xjtu.edu.cn
ORCID iD: 0000-0002-0427-2842

PhD, Professor, Dean of the School of Public Health

China, Xi'an

A. A. Tinkov

I.M. Sechenov First Moscow State Medical University (Sechenov University); P.G. Demidov Yaroslavl State University

Email: tinkov.a.a@gmail.com
ORCID iD: 0000-0003-0348-6192

Dr. Sc. (Med.), Leading Research Scienntist of the Laboratory of Molecular Dietetics; Senior Researcher of the Laboratory of Ecobiomonitoring and Quality Control

Russian Federation, Moscow; Yaroslavl

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