Multifactoriality of hyperfermentation in children of early neonatal period in acute pneumonias
- Authors: Gilmiyarova F.N.1, Kuznetsova O.Y.1, Gorbacheva I.V.1, Milokhova E.A.1, Sharafutdinova I.A.1
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Affiliations:
- Samara State Medical University of the Ministry of Health of Russia
- Issue: Vol 27, No 12 (2024)
- Pages: 100-109
- Section: Medical chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/643437
- DOI: https://doi.org/10.29296/25877313-2024-12-13
- ID: 643437
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Abstract
The aim is to evaluate haematological and biochemical blood parameters in pneumonia in children of early neonatal period to reveal multivariability of clinical and laboratory syndromes.
Material and Methods. The analysis of haematological, biochemical parameters, blood gas composition and COS in 33 children of early neonatal age with pneumonia (19 of them premature, 14 – premature), as well as 35 healthy newborns was carried out. The study was conducted on the basis of the Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostics of SamSMU, State Budgetary Institution SODKB named after N.N. Ivanova. The diagnosis was verified by instrumental methods of research.
Results. The peculiarities of the course of pneumonia in children of early neonatal period were revealed: development of leukocytosis (+29%) and increase in the absolute number of lymphocytes in premature (+39%); formation of thrombocytopenia, most pronounced in premature (-42%). The metabolic status was characterised by: A picture of catabolic stress, with a decrease in total protein (-35% in preterm; -33% in premature), an increase in urea levels (+77% in premature), especially pronounced in premature infants (2.6-fold) and creatinine (+53%; p<0.05 in preterm and +29% in preterm); significant increase in hyperbilirubinaemia (+53% in preterm, +70% in preterm). The most extensive in the examined contingent of children are changes in the total activity of ALAT and ASAT (7.5-fold and 7-fold, in preterm and 1.7-fold and 2.7-fold, in preterm). The analysis of possible multiple causes of hypertransaminasemia in the early neonatal period in pneumonia was carried out: catabolic orientation of metabolism, toxic load on functionally immature hepatocytes, large-scale haemolysis of erythrocytes, the possibility of ischaemic changes in the myocardium.
Conclusion. Multivariability of hypertransaminasemia may be a source of errors in interpretation of results in children of early neonatal period.
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About the authors
F. N. Gilmiyarova
Samara State Medical University of the Ministry of Health of Russia
Email: i.v.gorbacheva@samsmu.ru
ORCID iD: 0000-0001-5992-3609
Dr.Sc. (Med.), Professor, Honoured Scientist of the Russian Federation, Professor of the Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostics
Russian Federation, 171 Artsybushevskaya St., Samara, 443001O. Yu. Kuznetsova
Samara State Medical University of the Ministry of Health of Russia
Email: i.v.gorbacheva@samsmu.ru
ORCID iD: 0009-0006-5576-3074
Ph.D. (Med.), Associate Professor of the Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostics
Russian Federation, 171 Artsybushevskaya St., Samara, 443001I. V. Gorbacheva
Samara State Medical University of the Ministry of Health of Russia
Author for correspondence.
Email: i.v.gorbacheva@samsmu.ru
ORCID iD: 0000-0002-8267-9250
кандидат медицинских наук, доцент кафедры фундаментальной и клинической биохимии с лабораторной диагностикой
Russian Federation, 171 Artsybushevskaya St., Samara, 443001E. A. Milokhova
Samara State Medical University of the Ministry of Health of Russia
Email: i.v.gorbacheva@samsmu.ru
ORCID iD: 0009-0005-2416-6202
Ph.D. (Med.), Associate Professor of the Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostics Assistant of the Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostics, Head of the Clinical Diagnostic Laboratory
Russian Federation, 171 Artsybushevskaya St., Samara, 443001I. A. Sharafutdinova
Samara State Medical University of the Ministry of Health of Russia
Email: i.v.gorbacheva@samsmu.ru
ORCID iD: 0000-0001-7314-0221
Student, Institute of Paediatrics
Russian Federation, 171 Artsybushevskaya St., Samara, 443001References
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