Antiviral activity of compounds containing a structural fragment of benzopyran-2-one
- Authors: Zolotyh D.S.1, Dayronas Z.V.1, Pozdnyakov D.I.1
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Affiliations:
- Pyatigorsk Medical and Pharmaceutical Institute
- Issue: Vol 25, No 6 (2022)
- Pages: 22-27
- Section: Articles
- URL: https://journals.eco-vector.com/1560-9596/article/view/112973
- DOI: https://doi.org/10.29296/25877313-2022-06-03
- ID: 112973
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Abstract
Benzopyran-2-oh derivatives are characterized by an extensive spectrum of pharmacological activity, among which antiviral properties are particularly distinguished. It is worth noting that both natural derivatives of benzopyran-2-one and their semi-synthetic analogues have antiviral activity. It is particularly relevant to evaluate the effectiveness of benzopyran-2-one derivatives in relation to the SARS-CoV-2 virus. A number of studies indicate that benzopyran-2-ones are able to suppress the main virulence factors of SARS-CoV-2: the receptor-binding domain of the S-protein, the main and papain-like proteases. As SARS-CoV-2 inhibiting agents, hebulinic acid and punicalagin are of the greatest interest, which combine a polyvalent mechanism of antiviral action, high efficiency and low toxicity.
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About the authors
D. S. Zolotyh
Pyatigorsk Medical and Pharmaceutical Institute
Email: metranidazol@mail.ru
Ph.D. (Pharm.) Associate Professor, Analytical Chemistry Department
Russian Federation,Z. V. Dayronas
Pyatigorsk Medical and Pharmaceutical Institute
Email: daironas@mail.ru
Dr.Sc. (Pharm.), Professor, Department of Pharmacognosy, Botany and Technology of Phytopreparations
Russian Federation,D. I. Pozdnyakov
Pyatigorsk Medical and Pharmaceutical Institute
Author for correspondence.
Email: pozdniackow.dmitry@yandex.ru
Ph.D. (Pharm.), Head of Living System Laboratory, Associate Professor of Department of Pharmacology with Clinical Pharmacology Course
Russian Federation,References
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