Study of the elemental composition of extracts from different fractions of maral antlers

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Abstract

Introduction. Currently, medicines based on antler raw materials are gaining popularity due to their rich biological composition and biostimulating activity. However, these drugs must be safe for medical use, so it is necessary to study their mineral composition.

The aim of the study – to determine the mineral composition, including heavy metals and arsenic in dry extracts from maral antlers.

Material and methods. The objects of the study were various fractions of maral antlers produced in a pharmaceutical factory. Mineralization of the samples was carried out by microwave decomposition. The elemental composition of the studied objects was determined by inductively coupled plasma mass spectrometry.

Results: The content of 27 elements (Li, Na, Mg, Al, P, K, Ca, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, As, Sr, Mo, Pd, Ag, Cd, Sb, Ba, Hg, Tl, Pb, Bi) in the studied extracts was determined. Manganese, silver, cadmium, mercury, thallium, bismuth were not detected in the samples, the content of 21 elements was in the range of 0.009 – 70740,912 mg / kg, the amounts of toxic elements (Pb, Cd, As, Hg) were from 0 to 1.741 mg / kg. Calcium, phosphorus, sodium and potassium were found in the largest quantities, iron and copper were the microelements, and cobalt, molybdenum and arsenic were found in the smallest quantities. The maximum number of elements was contained in the bone-mineral component, and the minimum in the water-protein component. This is due to the biological characteristics of the original medicinal raw material.

Conclusion. The results of the study are consistent with the literature data. The possible intake of minerals into the human body was calculated when consuming extracts from different fractions of maral antlers. It was found that the number of elements does not exceed the upper permissible levels of daily consumption and the extracts are safe for medical use.

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About the authors

M. S. Galenko

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: marta.galenko@mail.ru
ORCID iD: 0000-0002-9050-5947

Applicant of the Department of Pharmaceutical Natural Science, Institute of Pharmacy

Russian Federation, Moscow

S. M. Safronov

Visterra LLC

Email: director@visterra.ru

Ph.D. (Chem.), General Director

Russian Federation, Altayskoe

I. V. Gravel

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: gravel_i_v@staff.sechenov.ru
ORCID iD: 0000-0002-3735-2291

Dr. Sc. (Pharm.), Professor of the Department of Pharmaceutical Natural Science, Institute of Pharmacy

Russian Federation, Moscow

References

  1. Zemcova N.P., Zverev Ya.F., Tureckova V.F. Comparative general tonic activity of crushed maral antlers. Fundamental research. 2014; 6(1): 100–103. (In Russ.).
  2. Mihajlov N.O. The use of maral antlers and blood in the treatment of soft tissue wounds. Molodezhnyj innovacionnyj vestnik. 2022; 11(1): 32–33. (In Russ.).
  3. Smirnova I.N., Suslov N.I., Hlusov I.A. i dr. Experimental justification of the use of maral antlers against the background of extreme psycho-emotional stress. Biomedicina. 2019; 15(3): 33–40. (In Russ.).
  4. Vereshchagina S.V., Smirnova I.N., Abdulkina N.G., Barankin B.V. Efficiency of using maral antlers in correcting immune dysfunction in athletes. Modern issues in biomedicine. 2021; 5(4 (17)): 10–18. (In Russ.).
  5. GPA.1.2.2.2.0012 Heavy metals. State Pharmacopoeia of the Russian Federation. XV ed. T. 1. M.; 2023. (In Russ.).
  6. GPA.1.4.1.0021 Extracts. State Pharmacopoeia of the Russian Federation. XV ed. T. 1. M.; 2023. (In Russ.).
  7. USP44–NF39. Rockville, MD; 2020.
  8. European Pharmacopoeia. 10th ed. Strasbourg: EDQM; 2020.
  9. SanPiN 2.3.2.1078-01 Food raw materials and food products. Hygienic requirements for the safety and nutritional value of food products. Moscow: Ministry of Health of Russia, 2002. (In Russ.).
  10. Shchukin V.M., Zhigiley E.S., Erina A.A. i dr. Validation of an ICP-MS method for the determination of mercury, lead, cadmium and arsenic in medicinal plants and related drug preparations. Pharmaceutical Chemistry Journal. 2020; 54(9): 57–64 (In Russ.).
  11. Lunitsyn V.G., Nepriyatel A.A., Belozerskikh I.S. Comparative analysis of the biochemical composition of antlers and secondary products of antler reindeer herding with concentrates made from them. Bulletin of the Altai State Agrarian University. 2016; 3(137): 122–126. (In Russ.).
  12. Galenko M.S., Lavrova O.S., Grigorieva V.Yu., Gravel I.V. Study of the content of heavy metals and arsenic in dry extracts from medicinal plant materials of different morphological groups. Farmatsiya, 2024; 73(6): 5–10; https://doi.org/10.29296/25419218-2024-06-01 (In Russ.).
  13. Gravel I.V., Shoikhet Ya.N., Yakovlev G.P. Pharmacognosy. Ecotoxicants in medicinal plant materials and phytopreparations: a tutorial. Moscow: GEOTAR-Media; 2012. (In Russ.).
  14. TR CU 022/2011. Technical regulations of the Customs Union. Food products in terms of their labeling. M., 2011 (In Russ.).
  15. Uniform sanitary-epidemiological and hygienic requirements for products (goods) subject to sanitary-epidemiological supervision (control), Appendix 5. M., 2010. (In Russ.).

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