Does threonine possess any ketogenic action?


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With diabetes the glucogenic or ketogenic character of one or another amino acid reveals itself more distinctly. The introduction of the former into the organism decreases the ketosis indication, whereas that of the latter increases this meaning.Threonine is conventionally considered to be the glucogenic amino acid like phenylalanine, tyrosine and isoleucine. As it is stated in the present paper, in the process of evolution a man on the genetic level lost the ability to the synthesis of threoninedehydrogenase - a ferment which can be found with many animals and which could participate in transformation of threonine to acetyl - koa, and therefore to ketone bodies. Thus, conclusion about the full absence of ketogenic action with man can be made.

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作者简介

A. Malinovsky

Biofizpribor, Branch of Federal Medical-Biological Agency

Email: info@biofizpribor.ru
Engineer-technologist St. Petersburg, Russia

参考

  1. Уайт А., Хендлер Ф., Смит Э., Хилл Р., Леман И. Основы биохимии. М.: Мир. 1981
  2. Voet D., Voet J.G. Biochemistry. 2nd ed. New York. Wiley. 1995.
  3. Garret R.H., Grisham C.M. Biochemistry. Orlando. Saunders College Publishing. 1995.
  4. Дэгли С., Никольсон Д. Метаболические пути. М.: Мир. 1973 [Djegli S., Nikol'son D. Metabolicheskie puti. M.: Mir. 1973 (in Russ.)].
  5. Neuberger A. Glycine formation from L-threonine. Comp. Biochem. 1981; 19A: 257-303.
  6. Bird M.I., Nunn P.B. Measurement of L-threonine aldolase activity in rat liver. Biochem. Soc. Trans. 1979; 7: 1274-1276.
  7. Yeung, Y.G. Threonine aldolase is not a genuine enzyme in rat liver. Biochem. J. 1986; 237: 187-190.
  8. Pagani R. L-allothreonine and L-threonine aldolase in rat liver. Biochem. Soc. Trans. 1991; 19(3): 3465.
  9. Darling P. B., Grunov J., Rafii M., Brookes S., Ball R.O., Pencharz P.B. Threonine dehydrogenase is a minor degratative pathway of threonine catabolism in adult humans. Am. J. Physiol. Endocrinol. Metab. 2000; 278: 877-884.
  10. Schirch I., Gross T. Serine transhydroxymethylase Identification as the threonine and allothreonine aldolases. J. Biol. Chem. 1968; 243: 5651-5655.
  11. Ogawa H., Gomi T., Fujioka. M. Serine hydroxymethyltrans-ferase and threonine aldolase are they identical? The International Journal of Biochemistry and Cell Biology. 2000; 32: 289-301.
  12. Покровский А.А. Роль биохимии в развитии науки о питании. М.: Наука. 1974. [Pokrovskij А.А. Rol biohimii v razvitii nauki o pitanii. M. Nauka.1974 (in Russ.)]
  13. Watanabe R., Fujimura S., Kadowaki M., Ishibashi T. Effects of dietary threonine levels on the threonine-degrading enzyme activities and tissue threonine related amino acid concentration in rats. Anim. Sci. Technol. (Jpn.). 1998; 69: 108-116.
  14. House J.D., Hall B.N., Brosnan J.T. Threonine metabolism in isolated rat hepatocytes. Am. J. Physiol. Endocrinol. Metab. 2002; 281: Е1300-Е1307.
  15. Nagao K., Bannai M., Seki S., Mori M., Takahashi M. Adaptational modification of serine and threonine metabolism in the liver to essential amino acid deficiency in rats. Amino Acids. 2009. Мarch.
  16. Zhao X.H., Wen Z.M., Meredith C.N., Matthews D.E., Bier D.M., Young V.R. Threonine kinetics at graded threonine intakes in young men. Am. J. Cln. Nutr. 1986; 43: 795-798.
  17. Edgar A.J. The human L-threonine-3-dehydrogenase gene is an expressed pseudogene. BMC Biochem. 2002; 18(3).
  18. Chuanchin H., Hao G., Jiaxu W., Weiguang L., Yide M., Mian W. Regulation of L-threonine dehydrogenase in somatic cell reprogramming. Stem. Cells. 2013: 31: 953-965.
  19. Winkle L.J.V., Gallet V., Iannaccone P.M. Threonine appears to be essential for proliferation of human as well as mouse embryonic stem cells. Cells and developmental biology. 2014. May 2. Article 18/1.
  20. Wurtman R.J. L-threonine for regulating glycine levels in the brain and spinal cord. European patent specification. 1986. Publication Number: 0 028 257 B1.
  21. D ’Mello J.P.F. Aspects of threonine and glycine metabolism in the chick (Gallus domesticus). J. Nutr. 1973; 15(6):. 357-363.57 B1.

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