Antioxidant effects of 11-deoxymisoprostol in experimental liver damage with carbon tetrachloride

Relevance. The development of new effective antioxidant drugs, the identification and specification of the properties of antioxidants in drugs of other pharmacological groups remains relevant. The substance studied in this work, ethyl ester of (±) -11,15-dideoxy-16-methyl-16-hydroxyprostaglandin E1 (11-deoxymisoprostol), is considered as a promising drug with a broad spectrum of pharmacological activity and antioxidant properties. Objective. Evaluation of the antioxidant activity of 11-deoxymisoprostol in tissues, blood and erythrocytes during the induction of free radical pathology by experimental liver damage with carbon tetrachloride. Material and methods. The study was carried out on 40 male rats. An experimental model of liver damage with carbon tetrachloride (single intraperitoneal administration of CCl4 at a dose of 0.5 ml / kg) was used to induce free radical pathology. Animals of the experimental group and the comparison group in the next 72 hours intragastrically, daily at a dose of 1 mg / kg, received 11-deoxyimisoprostol and the reference drug (misoprostol), respectively. The control animals received equivalent volumes of the solvent at the same rate. The levels of primary, secondary and final products of lipid peroxidation, products of oxidative modification of proteins, activity of glutathione peroxidase, superoxide dismutase, and catalase were determined in blood and liver homogenates. Results. The three-day administration of 11-deoxyimisoprostol, like the reference drug, did not prevent the development of ССЦ-dependent oxidative stress, but significantly limited its manifestations and modified its character, eliminating the phenomena of carbonyl stress. In terms of the severity of the effect, 11-deoxyimisoprostol was superior to the comparison drug (redistribution of the balance of products oxidative modification of proteins with restoration of the control values of the reserve-adaptive potential and preservation of catalase activity in the liver). Conclusions. Based on the results of the study, it is possible to draw unambiguous conclusions that 11- deoxyimisoprostol has antioxidant properties that are not inferior in severity to the reference drug.

11-deoxyimisoprostol, misoprostol, antioxidant, carbon tetrachloride, liver