Dipeptide BDNF mimetic GSB-106 prevents depression-like behavior and cognitive impairment caused by ischemic stroke in rats
- Authors: Povarnina P.Y.1, Nikiforov D.M1, Vorontsova O.N1, Gudasheva T.A1
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Affiliations:
- FSBI «Zakusov Institute of Pharmacology»
- Issue: Vol 25, No 2 (2022)
- Pages: 49-53
- Section: Articles
- URL: https://journals.eco-vector.com/1560-9596/article/view/112936
- DOI: https://doi.org/10.29296/25877313-2022-02-08
- ID: 112936
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Abstract
Relevance. Depression and cognitive impairment are common complications of acute cerebrovascular accidents. Disorders of hippocampal neuroplasticity associated with a decrease in BDNF expression are considered as one of the causes of these complications. A dimeric dipeptide mimetic of the BDNF loop 4, (bis (N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide) (GSB-106) was created at the V.V. Zakusov Research Institute of Pharmacology. GSB-106 demonstrated antidepressant, neuroprotective and neuroregenera-tive properties in in vivo experiments. Objective. Experiments were performed on 40 male rats Wistar weighing 240-280 g. Purpose of the study is to investigate the effect of GSB-106 on depression-like behavior and memory impairments in rats induced by middle cerebral artery occlusion (MCAO). Material and methods. GSB-106 was injected intraperitoneally at a dose of 0.1 mg/kg for 21 days after surgery. Depressive-like be havior was detected in the forced swimming test, and memory impairments - in the novel object recognition test. Conclusions. GSB-106 is a promising compound for further development as a drug for the treatment of post-stroke depression and cognitive impairment.
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About the authors
P. Yu Povarnina
FSBI «Zakusov Institute of Pharmacology»
Email: povarnina@gmail.com
Ph.D. (Biol.)
Moscow, RussiaD. M Nikiforov
FSBI «Zakusov Institute of Pharmacology»
Email: povarnina@gmail.com
Ph.D. (Biol.)
Moscow, RussiaO. N Vorontsova
FSBI «Zakusov Institute of Pharmacology»
Email: povarnina@gmail.com
Ph.D. (Biol.)
Moscow, RussiaT. A Gudasheva
FSBI «Zakusov Institute of Pharmacology»
Author for correspondence.
Email: povarnina@gmail.com
Ph.D. (Biol.), Professor, Member-corr. of RAS
Moscow, RussiaReferences
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