Determination of the level of valproic acid in the blood against the background of the combined use of valproates with ertapenem in pediatric practice
- 作者: Strok A.B.1,2, Chenkurov M.S.1, Kostyleva M.N.3,4, Umutkuzina D.A.5
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隶属关系:
- «Peoples' Friendship University of Russia (PFUR) named after Patrice Lumumba»
- «Russian Children's Clinical Hospital is a Branch of the «N.I. Pirogov Russian National Research Medical University" of the Ministry of Health of the Russian Federation»
- «Russian Children's Clinical Hospital is a Branch of the «N.I. Pirogov Russian National Research Medical University" of the Ministry of Health of the Russian Federation
- "N.I. Pirogov Russian National Research Medical University" of the Ministry of Health of the Russian Federation
- City Clinical Hospital named after M.E. Zhadkevich
- 期: 卷 26, 编号 11 (2023)
- 页面: 74-79
- 栏目: Medical chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/623589
- DOI: https://doi.org/10.29296/25877313-2023-11-12
- ID: 623589
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详细
The article presents a clinical case of the combined use of valproic acid and an antibacterial drug from the carbapenem group – ertapenem in a 15-year-old girl with epilepsy in a pediatric hospital. Therapeutic drug monitoring with an assessment of the level of valproic acid in blood plasma against the background of joint use with carbapenem (ertapenem) allowed to revise and adjust the prescribed antibacterial therapy, and later allowed to adjust the daily dose of sodium valproate in a child with epilepsy. The change of the antibacterial drug was accompanied by an increase in the level of valproic acid in the blood plasma. The transition from intravenous administration of valproic acid to enteral administration of the drug was accompanied by a decrease in the concentration of valproic acid in blood plasma. The authors of the article presented data confirming the need for therapeutic drug monitoring in children receiving valproic acid and beta-lactam antibiotic from the carbapenem group - ertapenem, based on the known mechanisms of famacokinetic interaction, as well as in patients whose management tactics are planned to change the dosage form of valproic acid.
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作者简介
A. Strok
«Peoples' Friendship University of Russia (PFUR) named after Patrice Lumumba»; «Russian Children's Clinical Hospital is a Branch of the «N.I. Pirogov Russian National Research Medical University" of the Ministry of Health of the Russian Federation»
编辑信件的主要联系方式.
Email: strok_ab@pfur.ru
Ph.D. (Med.), Assistant of Department of General and Clinical Pharmacology, Clinical Pharmacologist
俄罗斯联邦, Moscow; MoscowM. Chenkurov
«Peoples' Friendship University of Russia (PFUR) named after Patrice Lumumba»
Email: chenkurov_ms@pfur.ru
Ph.D. (Biol.), Assistant of Department of General and Clinical Pharmacology
俄罗斯联邦, MoscowM. Kostyleva
«Russian Children's Clinical Hospital is a Branch of the «N.I. Pirogov Russian National Research Medical University" of the Ministry of Health of the Russian Federation; "N.I. Pirogov Russian National Research Medical University" of the Ministry of Health of the Russian Federation
Email: mkostyleva@mail.ru
Ph.D. (Med.), Head of Department of Clinical Pharmacology, Clinical Pharmacologist; Associate Professor
俄罗斯联邦, Moscow; MoscowD. Umutkuzina
City Clinical Hospital named after M.E. Zhadkevich
Email: umutkuzinada@gmail.com
Clinical Pharmacologist
俄罗斯联邦, Moscow参考
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