Email this article Clinical features of novel coronavirus infection (omicron variant) in patients with end-stage kidney disease
- Authors: Miklush P.I.1, Zhdanov K.V.1,2,3, Belskikh A.N.1, Kozlov K.V.1, Shvedov A.K.1, Zakharov M.V.1, L'vov N.I.1, Sopova N.Y.1, Lyashenko Y.I.1, Komarova A.Y.3, Korneenkova D.Y.1
-
Affiliations:
- Kirov Military Medical Academy
- Children’s Scientific and Clinical Center of Infectious Diseases
- Saint Petersburg State University
- Issue: Vol 27, No 2 (2025)
- Pages: 175-184
- Section: Original Study Article
- Submitted: 15.02.2025
- Accepted: 31.03.2025
- Published: 23.06.2025
- URL: https://journals.eco-vector.com/1682-7392/article/view/656013
- DOI: https://doi.org/10.17816/brmma656013
- EDN: https://elibrary.ru/IVPODL
- ID: 656013
Cite item
Open Access
Access granted
Abstract
BACKGROUND: Before the emergence of the omicron variant, novel coronavirus infection in patients with end-stage kidney disease was characterized by a severe course and poor prognosis. Since January 2022, the omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been the most prevalent strain in Russia. This strain is associated with uncommon virus-induced lung injury and significantly lower hospitalization and mortality rates compared to previous variants.
AIM: This study aimed to assess the course of the omicron variant of SARS-CoV-2 in patients with end-stage kidney disease.
METHODS: The retrospective cohort study included 33 medical records of patients with end-stage kidney disease who had been treated for novel coronavirus infection at the Infectious Diseases Clinic of Kirov Military Medical Academy and Botkin Clinical Infectious Diseases Hospital between January 2022 and February 2024. Following a comprehensive analysis of the medical records, the patients were divided into two groups. Group 1 included 12 patients with novel coronavirus infection in the form of acute respiratory viral infection without lung involvement. Group 2 comprised 21 patients with virus-induced lung injury.
RESULTS: The omicron variant of SARS-CoV-2 frequently caused lung injury, including acute respiratory failure, in patients with end-stage kidney disease. The early stages of inpatient treatment for this group of patients were characterized by fever (≥ 37.2°C), tachycardia (≥ 90 bpm), National Early Warning Score ≥ 4, and prolonged viral shedding (12 [10; 18] vs 9 [7,5; 9,5] days, p = 0.002).
CONCLUSION: The high prevalence of comorbidities and frequent occurrence of virus-induced lung injury leading to acute respiratory failure underscore a unique cohort of patients with end-stage kidney disease requiring programmed hemodialysis and highlight the ongoing challenge of novel coronavirus infection, even during the spread of the omicron variant of SARS-CoV-2.
Full Text
About the authors
Panteley I. Miklush
Kirov Military Medical Academy
Author for correspondence.
Email: vmeda-nio@mil.ru
ORCID iD: 0000-0002-5668-462X
SPIN-code: 1599-4487
Adjunct
Russian Federation, Saint PetersburgKonstantin V. Zhdanov
Kirov Military Medical Academy; Children’s Scientific and Clinical Center of Infectious Diseases; Saint Petersburg State University
Email: vmeda-nio@mil.ru
ORCID iD: 0000-0002-3679-1874
SPIN-code: 7895-2075
MD, Dr. Sci. (Medicine), Professor
Russian Federation, Saint Petersburg; Saint Petersburg; Saint PetersburgAndrey N. Belskikh
Kirov Military Medical Academy
Email: vmeda-nio@mil.ru
ORCID iD: 0000-0002-0421-3797
SPIN-code: 7764-0930
MD, Dr. Sci. (Medicine), Professor
Russian Federation, Saint PetersburgKonstantin V. Kozlov
Kirov Military Medical Academy
Email: vmeda-nio@mil.ru
ORCID iD: 0000-0002-4398-7525
SPIN-code: 7927-9076
MD, Dr. Sci. (Medicine), Professor
Russian Federation, Saint PetersburgAnatoly K. Shvedov
Kirov Military Medical Academy
Email: vmeda-nio@mil.ru
ORCID iD: 0009-0006-1586-3564
SPIN-code: 6258-2587
MD, Dr. Sci. (Medicine), Professor
Russian Federation, Saint PetersburgMikhail V. Zakharov
Kirov Military Medical Academy
Email: vmeda-nio@mil.ru
ORCID iD: 0000-0001-6549-3991
SPIN-code: 4732-9877
MD, Cand. Sci. (Medicine), Associate Professor
Russian Federation, Saint PetersburgNikolay I. L'vov
Kirov Military Medical Academy
Email: vmeda-nio@mil.ru
ORCID iD: 0000-0003-4254-229X
SPIN-code: 8414-8612
MD, Dr. Sci. (Medicine), Associate Professor
Russian Federation, Saint PetersburgNatalia Yu. Sopova
Kirov Military Medical Academy
Email: vmeda-nio@mil.ru
ORCID iD: 0009-0004-0747-5540
SPIN-code: 5780-9082
Russian Federation, Saint Petersburg
Yuri I. Lyashenko
Kirov Military Medical Academy
Email: vmeda-nio@mil.ru
ORCID iD: 0000-0001-9163-7012
SPIN-code: 5404-0988
MD, Dr. Sci. (Medicine), Professor
Russian Federation, Saint PetersburgAlexandra Ya. Komarova
Saint Petersburg State University
Email: vmeda-nio@mil.ru
ORCID iD: 0000-0001-6753-9180
SPIN-code: 6999-5874
MD, Cand. Sci. (Medicine), Associate Professor
Russian Federation, Saint PetersburgDiana Yu. Korneenkova
Kirov Military Medical Academy
Email: vmeda-nio@mil.ru
ORCID iD: 0009-0005-9709-0296
Cadet
Russian Federation, Saint PetersburgReferences
- Xiong F, Tang H, Liu L, et al. Clinical characteristics of and medical interventions for COVID-19 in hemodialysis patients in Wuhan, China. J Am Soc Nephrol. 2020;31(7):1387–1397. doi: 10.1681/ASN.2020030354
- Goodlad C, Davenport A. The changing pattern of COVID-19 infection in haemodialysis and peritoneal dialysis patients. Artif Organs. 2023;47(7): 1202–1207. doi: 10.1111/aor.14526
- Frolova NF, Kim IG, Ushakova AI, et al. COVID-19 in hemodialysis patients. Infectious Diseases: News, Opinions, Training. 2021;10(1):14–23. doi: 10.33029/2305-3496-2021-10-1-14-23 EDN: RYXXQM
- Ng JH, Hirsch JS, Wanchoo R, et al. Outcomes of patients with end-stage kidney disease hospitalized with COVID-19. Kidney Int. 2020;98(6): 1530–1539. doi: 10.1016/j.kint.2020.07.030
- Guidotti R, Pruijm M, Ambühl PM. COVID-19 pandemic in dialysis patients: The swiss experience. Front Public Health. 2022;10:795701. doi: 10.3389/fpubh.2022.795701
- Yavuz D, Karagöz Özen DS, Demirağ MD. COVID-19: mortality rates of patients on hemodialysis and peritoneal dialysis. Int Urol Nephrol. 2022;54(10):2713–2718. doi: 10.1007/s11255-022-03193-6
- Andreenko AA, Andrejchuk JuV, Arsent’ev VG, et al. Infection caused by SARS-CoV-2. Krjukov EV, editor. Saint-Petersburg: Kirov Military Medical Academy; 2023. 260 p. EDN: QFKFPF (In Russ.)
- Chawki S, Buchard A, Sakhi H, et al. Long-term impact of COVID-19 among maintenance haemodialysis patients. Clin Kidney J. 2021;15(2): 262–268. doi: 10.1093/ckj/sfab166
- O’Sullivan ED, Lees JS, Howie KL, et al. Prolonged SARS-CoV-2 viral shedding in patients with chronic kidney disease. Nephrology (Carlton). 2021;26(4):328–332. doi: 10.1111/nep.13844
- Shaikh A, Zeldis E, Campbell KN, Chan L. Prolonged SARS-CoV-2 viral RNA shedding and IgG antibody response to SARS-CoV-2 in patients on hemodialysis. Clin J Am Soc Nephrol. 2021;16(2):290–292. doi: 10.2215/CJN.11120720
- L’vov NI. ARVI and NKVI: from general concepts to the definition of nosological and clinical forms of diseases. In: Thesis’s of the V International forum: «Virology days»; 30 Sept 2024 – 01 Okt 2024; Saint-Petersburg. Saint-Petersburg: St. Petersburg public organization «Man and his health»; 2024. P. 67–68. (In Russ.)
- Akimkin VG, Popova AY, Khafizov KF, et al. COVID-19: evolution of the pandemic in Russia. Report II: dynamics of the circulation of SARS-CoV-2 genetic variants. Journal of microbiology, epidemiology and immunobiology. 2022;99(4):381–396. doi: 10.36233/0372-9311-295 EDN: KVULAS
- Arabi M, Al-Najjar Y, Mhaimeed N, et al. Severity of the Omicron SARS-CoV-2 variant compared with the previous lineages: A systematic review. J Cell Mol Med. 2023;27(11):1443–1464. doi: 10.1111/jcmm.17747
- Ilyin AP, Gurevich KYa, Denisov AYu, et al. The management of medical care with dialysis methods in outpatients during the COVID-19 pandemic. Nephrology and Dialysis. 2022;24(2):301–321. doi: 10.28996/2618-9801-2022-2-301-321 EDN: LWMQDN
- Zhdanov KV, Kozlov KV, Bulankov YuI, et al. Optimization of diagnosis of SARS-CoV-2 infection using polymerase chain reaction in a large multi-specialty hospital. Bulletin of the Russian Military Medical Academy. 2020;22(2):7–10. doi: 10.17816/brmma50036 EDN: FQVQWY
- Ministry of Health of the Russian Federation. Temporary methodological recommendations. Prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Version-18 (26.10.2023). Moscow: Ministry of Health of the Russian Federation; 2023. 250 p. (In Russ.)
- Unguryanu TN, Grjibovski AM. Brief recommendations on description, analysis and presentation of data in scientific papers. Human ecology. 2011;(5):55–60. EDN: NRDBMN (In Russ.)
- Kryukov EV, Zhdanov KV, Kozlov KV, et al. Electron microscopic changes in the nasal membrane of patients with COVID-19 depending on the clinical form and the period of the disease. Journal Infectology. 2021;13(2):5–13. doi: 10.22625/2072-6732-2021-13-2-5-13 EDN: UYWDWK
- Platonova TA, Semenenko TA, Golubkova AA, et al. Prognostic criteria for the development of severe clinical forms of COVID-19 in medical organization workers. Infectious Diseases: News, Opinions, Training. 2022;11(4):19–29. doi: 10.33029/2305-3496-2022-11-4-19-29 EDN: GZNBLD
- Lalueza A, Lora-Tamayo J, de la Calle C, et al. The early use of sepsis scores to predict respiratory failure and mortality in non-ICU patients with COVID-19. Rev Clin Esp (Barc). 2022;222(5):293–298. doi: 10.1016/j.rceng.2020.10.004
Supplementary files
