Intraoperative photodynamic therapy in the structure of complex treatment of patients suffering from recurrence and continued growth of intracranial meningioma
- 作者: Kukanov K.K.1, Nechaeva A.S.1,2, Sitovskaya D.A.1, Dikonenko M.V.1,3, Sukhoparov P.D.4, Ishchenko I.O.4, Zabrodskaya Y.M.1, Samochernykh N.K.3, Papayan G.V.3, Olushin V.E.1, Samochernykh K.A.3
-
隶属关系:
- Russian Research Neurosurgical Institute named after prof. A.L. Polenova
- World-class scientific center "Center for Personalized Medicine"
- V.A. Almazov National Medical Research Center
- Saint Petersburg State Pediatric Medical University
- 期: 卷 26, 编号 2 (2024)
- 页面: 243-258
- 栏目: Research paper
- ##submission.dateSubmitted##: 06.12.2023
- ##submission.dateAccepted##: 09.04.2024
- ##submission.datePublished##: 03.06.2024
- URL: https://journals.eco-vector.com/1682-7392/article/view/624272
- DOI: https://doi.org/10.17816/brmma624272
- ID: 624272
如何引用文章
详细
The effectiveness and safety of intraoperative photodynamic therapy in patients with recurrent intracranial meningiomas were examined. Intraoperative photodynamic therapy was performed in three patients suffering from relapse and continued growth of histologically confirmed intracranial meningiomas of supratentorial localization. Intraoperative photodynamic therapy was conducted with consent from patients and was confirmed by a medical commission. We used a photosensitizer of the chlorin e6 group — photoditazine (Veta-Grand, Russia). The drug was administered intravenously at a dose of 1 mg/kg during induction of anesthesia. For irradiation, laser installation Latus (ATKUS, St. Petersburg, Russia) with a power of 2.5 W and wavelength of 662 nm was used. Irradiation was conducted in a continuous mode; the duration of therapy depended on the area of the irradiated surface based on a therapeutic light dose of 180 J/cm2. In the early postoperative period, the patients’ eyes were protected for 24 h from exposure to direct sunlight, and clinical, laboratory, and intrascopic controls were carried out. No complications associated with intraoperative photodynamic therapy were observed in the early postoperative period. On control intrascopy (magnetic resonance imaging in DWI, Flair, T2, T1 + contrast modes), data showing the therapeutic effect of intraoperative photodynamic therapy were obtained. In two cases, changes in tumor tissue and its matrix were confirmed pathomorphologically, indicating the therapeutic effect of intraoperative photodynamic therapy in relation to local control of meningiomas. Thus, the use of intraoperative photodynamic therapy in the complex treatment of patients suffering from a recurrent course of the neoplastic process (“aggressive” meningiomas) reveals its effectiveness for increasing the degree of radicality of the operation and safety. Further development of the technology of intraoperative photodynamic therapy is crucial in treating patients with “aggressive” meningiomas.
全文:
![受限制的访问](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
作者简介
Konstantin Kukanov
Russian Research Neurosurgical Institute named after prof. A.L. Polenova
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0002-1123-8271
SPIN 代码: 8938-0675
MD, Сand. Sci. (Med.), senior research associate
俄罗斯联邦, Saint PetersburgAnastasiia Nechaeva
Russian Research Neurosurgical Institute named after prof. A.L. Polenova; World-class scientific center "Center for Personalized Medicine"
Email: nastja-nechaeva00@mail.ru
ORCID iD: 0000-0001-9898-5925
SPIN 代码: 2935-0745
junior research associate
俄罗斯联邦, Saint Petersburg; Saint PetersburgDarya Sitovskaya
Russian Research Neurosurgical Institute named after prof. A.L. Polenova
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0001-9721-3827
SPIN 代码: 3090-4740
researcher
俄罗斯联邦, Saint PetersburgMikhail Dikonenko
Russian Research Neurosurgical Institute named after prof. A.L. Polenova; V.A. Almazov National Medical Research Center
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0002-8701-1292
SPIN 代码: 6920-5656
neurosurgeon
俄罗斯联邦, Saint Petersburg; Saint PetersburgPavel Sukhoparov
Saint Petersburg State Pediatric Medical University
编辑信件的主要联系方式.
Email: pashsukhoparov@gmail.com
ORCID iD: 0009-0007-3185-7348
SPIN 代码: 4066-7810
student
俄罗斯联邦, Saint PetersburgIlya Ishchenko
Saint Petersburg State Pediatric Medical University
Email: pashsukhoparov@gmail.com
ORCID iD: 0009-0006-9122-5935
SPIN 代码: 6451-5600
student
俄罗斯联邦, Saint PetersburgYulia Zabrodskaya
Russian Research Neurosurgical Institute named after prof. A.L. Polenova
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0001-6206-2133
SPIN 代码: 8571-3190
MD, Dr. Sci. (Med.)
俄罗斯联邦, Saint PetersburgNikita Samochernykh
V.A. Almazov National Medical Research Center
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0002-6138-3055
SPIN 代码: 6131-4468
a neurosurgeon
俄罗斯联邦, Saint PetersburgGarry Papayan
V.A. Almazov National Medical Research Center
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0002-6462-9022
SPIN 代码: 7327-7837
Сand. Sci. (Tech.), senior research associate
俄罗斯联邦, Saint PetersburgVictor Olushin
Russian Research Neurosurgical Institute named after prof. A.L. Polenova
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0002-9960-081X
MD, Dr. Sci. (Med.), professor
俄罗斯联邦, Saint PetersburgKonstantin Samochernykh
V.A. Almazov National Medical Research Center
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0003-0350-0249
SPIN 代码: 4188-9657
MD, Dr. Sci. (Med.), professor
俄罗斯联邦, Saint Petersburg参考
- El-Khatib M, Tepe C, Senger B, et al. Aminolevulinic acid-mediated photodynamic therapy of human meningioma: an in vitro study on primary cell lines. Int J Mol Sci. 2015;16(5):9936–9948. doi: 10.3390/ijms16059936
- Nakahara Y, Ito H, Masuoka J, Abe T. Boron neutron capture therapy and photodynamic therapy for high-grade meningiomas. Cancers (Basel). 2020;12(5):1334. doi: 10.3390/cancers12051334
- Konovalov AN, Kozlov AV, Cherekaev VA, et al. Meningioma challenge: analysis of 80-year experience of Burdenko neurosurgical institute and future perspectives. Burdenko’s Journal of Neurosurgery. 2013;77(1):12–23. EDN: PYATKB
- Tigliev GS, Olyushin VE, Kondratyev AN. Intracranial meningiomas. Saint Petersburg; 2001. 560 р. (In Russ.)
- Zabolotny RA, Fedyanin AV, Yulchiev UA, et al. Comprehensive treatment of patients with parasagittal meningiomas. Burdenko’s Journal of Neurosurgery. 2019;83(4):121–125. EDN: TUNBPQ doi: 10.17116/neiro201983041121
- Kukanov KK, Ushanov VV, Zabrodskaya YuM, et al. Ways to personalize the treatment of patients with relapse and continued growth of intracranial meningiomas. Russian Journal of Personalized Medicine. 2023;3(3):48–63. EDN: FZQSKY doi: 10.18705/2782-38062023-3-3-48-63
- Certificate of state registration of the database № RU 2023621571 / 02.05.2023 Kukanov KK, Ushanov VV, Voinov NE. Register of patients with relapse and continued growth of intracranial meningiomas. Moscow: 2023. 1 p. EDN: VBRSBM (In Russ.)
- Kukanov KK, Vorobyova OM, Zabrodskaya YuM, et al. Intracranial meningiomas: clinical, intrascopic and pathomorphological causes of recurrence (literature review). Siberian Journal of Oncology. 2022;21(4):110–123. (In Russ.) EDN: DBARSI doi: 10.21294/1814-4861-2022-21-4-110-123
- Schipmann S, Schwake M, Sporns PB, et al. Is the simpson grading system applicable to estimate the risk of tumor progression after microsurgery for recurrent intracranial meningioma? World Neurosurg. 2018;119:e589–e597. doi: 10.1016/j.wneu.2018.07.215
- Patent RUS № 2236270 / 20.09.2004. Tigliev GS, Chesnokova EA, Olyushin VE, et al. Method for treating the cases of malignant cerebral tumors having multifocal growth pattern. (In Russ.)
- Patent RUS № 2318542 / 10.03.2008. Comfort AV, Olyushin VE, Ruslyakova IA, et al. Method of photodynamic therapy for the treatment of glial tumors of the cerebral hemispheres. (In Russ.)
- Noske DP, Wolbers JG, Sterenborg HJ. Photodynamic therapy of malignant glioma. A review of literature. Clin Neurol Neurosurg. 1991;93(4):293–307. doi: 10.1016/0303-8467(91)90094-6
- Akimoto J. Photodynamic therapy for malignant brain tumors. Neurol Med Chir (Tokyo). 2016;56(4):151–157. doi: 10.2176/nmc.ra.2015-0296
- Ostrom QT, Gittleman H, Xu J, et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2009–2013. Neuro Oncol. 2016;18(5):1–75. doi: 10.1093/neuonc/now207
- Karnofsky DA, Burchenal JH. The clinical evaluation of chemotherapeutic agents in cancer. In: Evaluation of chemotherapeutic agents. MacLeod CM, editor. New York: Columbia University Press; 1949. P. 196.
- Al-Mefty, Ossama MD. Meningiomas. New York: Raven press; 1991. 630 p.
- Kiesel B, Freund J, Reichert D, et al. 5-ALA in suspected low-grade gliomas: current role, limitations, and new approaches. Front Oncol. 2021;11:699301. doi: 10.3389/fonc.2021.699301
- Reshetov IV, Korenev SV, Romanko YuS. Forms of cell death and targets at photodynamic therapy. Siberian Journal of Oncology. 2022;21(5):149–154. (In Russ.) EDN: ACMUZT doi: 10.21294/1814-4861-2022-21-5-149-154
- Rynda AYu, Rostovtsev DM, Olyushin VE, et al. Therapeutic pathomorphosis in malignant glioma tissues after photodynamic therapy with сhlorin e6 (reports of two clinical cases). Biomedical Photonics. 2020;9(2):45–54. (In Russ.) EDN: ATSWVP doi: 10.24931/2413-9432-2020-9-2-45-54
- Rynda AYu, Rostovtsev DM, Olyushin VE, et al. Fluorescence-guided resection of glioma — literature review. Rossiiskii neirokhirurgicheskii zhurnal imeni professora A. L. Polenova. 2018;10(1):97–110 (In Russ.) EDN: VGOGCW
- Rynda AYu, Olyushin VE, Rostovtsev DM, et al. Fluorescent diagnostics with chlorin E6 in surgery of low-grade glioma. Biomedical Photonics. 2021;10(4):35–43. (In Russ.) EDN: MPGCMB doi: 10.24931/2413-9432-2021-10-4-35-43
- Rynda AYu, Olyushin VE, Rostovtsev DM, et al. Intraoperative fluorescence control with chlorin E6 in resection of glial brain tumors. Burdenko’s Journal of Neurosurgery. 2021;85(4):20–28. EDN: IYTDSE doi: 10.17116/neiro20218504120
- Rynda AYu, Olyushin VE, Rostovtsev DM, et al. Comparative analysis of 5-ALA and chlorin E6 fluorescence-guided navigation in malignant glioma surgery. Pirogov Russian Journal of Surgery. 2022;(1):5–14. EDN: IBJRPM doi: 10.17116/hirurgia20220115
- Rafaelian AA, Alekseev DE, Martynov BV, et al. Stereotactic photodynamic therapy in the treatment of relapsed glioblastoma. Case from practice and literature review. Burdenko’s Journal of Neurosurgery. 2020;84(5):81–88. EDN: OCQSTL doi: 10.17116/neiro20208405181
- Rafaelian A, Martynov B, Chemodakova K, et al. Photodynamic interstitial stereotactic therapy for recurrent malignant glioma. Asian Journal of Oncology. 2023;9(14):1–9. EDN: LOMBOQ doi: 10.25259/ASJO-2022-69-(433)
补充文件
![](/img/style/loading.gif)