Intraoperative photodynamic therapy in the structure of complex treatment of patients suffering from recurrence and continued growth of intracranial meningioma
- Authors: Kukanov K.K.1, Nechaeva A.S.1,2, Sitovskaya D.A.1, Dikonenko M.V.1,3, Sukhoparov P.D.4, Ishchenko I.O.4, Zabrodskaya Y.M.1, Samochernykh N.K.3, Papayan G.V.3, Olushin V.E.1, Samochernykh K.A.3
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Affiliations:
- Russian Research Neurosurgical Institute named after prof. A.L. Polenova
- World-class scientific center "Center for Personalized Medicine"
- V.A. Almazov National Medical Research Center
- Saint Petersburg State Pediatric Medical University
- Issue: Vol 26, No 2 (2024)
- Pages: 243-258
- Section: Research paper
- Submitted: 06.12.2023
- Accepted: 09.04.2024
- Published: 03.06.2024
- URL: https://journals.eco-vector.com/1682-7392/article/view/624272
- DOI: https://doi.org/10.17816/brmma624272
- ID: 624272
Cite item
Abstract
The effectiveness and safety of intraoperative photodynamic therapy in patients with recurrent intracranial meningiomas were examined. Intraoperative photodynamic therapy was performed in three patients suffering from relapse and continued growth of histologically confirmed intracranial meningiomas of supratentorial localization. Intraoperative photodynamic therapy was conducted with consent from patients and was confirmed by a medical commission. We used a photosensitizer of the chlorin e6 group — photoditazine (Veta-Grand, Russia). The drug was administered intravenously at a dose of 1 mg/kg during induction of anesthesia. For irradiation, laser installation Latus (ATKUS, St. Petersburg, Russia) with a power of 2.5 W and wavelength of 662 nm was used. Irradiation was conducted in a continuous mode; the duration of therapy depended on the area of the irradiated surface based on a therapeutic light dose of 180 J/cm2. In the early postoperative period, the patients’ eyes were protected for 24 h from exposure to direct sunlight, and clinical, laboratory, and intrascopic controls were carried out. No complications associated with intraoperative photodynamic therapy were observed in the early postoperative period. On control intrascopy (magnetic resonance imaging in DWI, Flair, T2, T1 + contrast modes), data showing the therapeutic effect of intraoperative photodynamic therapy were obtained. In two cases, changes in tumor tissue and its matrix were confirmed pathomorphologically, indicating the therapeutic effect of intraoperative photodynamic therapy in relation to local control of meningiomas. Thus, the use of intraoperative photodynamic therapy in the complex treatment of patients suffering from a recurrent course of the neoplastic process (“aggressive” meningiomas) reveals its effectiveness for increasing the degree of radicality of the operation and safety. Further development of the technology of intraoperative photodynamic therapy is crucial in treating patients with “aggressive” meningiomas.
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About the authors
Konstantin K. Kukanov
Russian Research Neurosurgical Institute named after prof. A.L. Polenova
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0002-1123-8271
SPIN-code: 8938-0675
MD, Сand. Sci. (Med.), senior research associate
Russian Federation, Saint PetersburgAnastasiia S. Nechaeva
Russian Research Neurosurgical Institute named after prof. A.L. Polenova; World-class scientific center "Center for Personalized Medicine"
Email: nastja-nechaeva00@mail.ru
ORCID iD: 0000-0001-9898-5925
SPIN-code: 2935-0745
junior research associate
Russian Federation, Saint Petersburg; Saint PetersburgDarya A. Sitovskaya
Russian Research Neurosurgical Institute named after prof. A.L. Polenova
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0001-9721-3827
SPIN-code: 3090-4740
researcher
Russian Federation, Saint PetersburgMikhail V. Dikonenko
Russian Research Neurosurgical Institute named after prof. A.L. Polenova; V.A. Almazov National Medical Research Center
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0002-8701-1292
SPIN-code: 6920-5656
neurosurgeon
Russian Federation, Saint Petersburg; Saint PetersburgPavel D. Sukhoparov
Saint Petersburg State Pediatric Medical University
Author for correspondence.
Email: pashsukhoparov@gmail.com
ORCID iD: 0009-0007-3185-7348
SPIN-code: 4066-7810
student
Russian Federation, Saint PetersburgIlya O. Ishchenko
Saint Petersburg State Pediatric Medical University
Email: pashsukhoparov@gmail.com
ORCID iD: 0009-0006-9122-5935
SPIN-code: 6451-5600
student
Russian Federation, Saint PetersburgYulia M. Zabrodskaya
Russian Research Neurosurgical Institute named after prof. A.L. Polenova
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0001-6206-2133
SPIN-code: 8571-3190
MD, Dr. Sci. (Med.)
Russian Federation, Saint PetersburgNikita K. Samochernykh
V.A. Almazov National Medical Research Center
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0002-6138-3055
SPIN-code: 6131-4468
a neurosurgeon
Russian Federation, Saint PetersburgGarry V. Papayan
V.A. Almazov National Medical Research Center
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0002-6462-9022
SPIN-code: 7327-7837
Сand. Sci. (Tech.), senior research associate
Russian Federation, Saint PetersburgVictor E. Olushin
Russian Research Neurosurgical Institute named after prof. A.L. Polenova
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0002-9960-081X
MD, Dr. Sci. (Med.), professor
Russian Federation, Saint PetersburgKonstantin A. Samochernykh
V.A. Almazov National Medical Research Center
Email: pashsukhoparov@gmail.com
ORCID iD: 0000-0003-0350-0249
SPIN-code: 4188-9657
MD, Dr. Sci. (Med.), professor
Russian Federation, Saint PetersburgReferences
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