Effect of glyprolins on white blood cell parameters and phagocytic activity of neutrophils in conditions of experimental hyperthyroidism
- 作者: Sergalieva M.U.1, Tsybizova A.A.1, Andreeva L.A.2, Myasoedov N.F.2, Bashkina O.A.1, Samotrueva M.A.1
-
隶属关系:
- Astrakhan State Medical University
- Kurchatov Institute — Institute of Molecular Genetics
- 期: 卷 24, 编号 1 (2022)
- 页面: 55-60
- 栏目: Research paper
- ##submission.dateSubmitted##: 18.11.2021
- ##submission.dateAccepted##: 13.12.2021
- ##submission.datePublished##: 20.04.2022
- URL: https://journals.eco-vector.com/1682-7392/article/view/88670
- DOI: https://doi.org/10.17816/brmma88670
- ID: 88670
如何引用文章
详细
This study investigated the effects of glyproline neuropeptide compounds (selank and Pro-Gly-Pro) on the white blood cell count and phagocytic activity of neutrophils in 40 nonlinear white male rats aged 6–8 months with experimental hyperthyroidism. Experimental hyperthyroidism was simulated by intragastric administration of L-thyroxine sodium salt pentahydrate at a dose of 150 µg/kg/day for 21 days. All animals were equally divided into four groups: healthy rats (control), rats treated with L-thyroxine sodium pentahydrate (hyperthyroidism), rats treated with selank, and rats treated with Pro-Gly-Pro at doses of 200 µg/kg/day intraperitoneally for 21 days, starting one day after the last administration of L-thyroxine sodium pentahydrate. After the animals were removed from the experiment, the white blood cell count and the percentage of lymphocytes, stick, and segmentonuclear neutrophils were calculated, and the phagocytic activity of neutrophils was evaluated. In the case of experimental hyperthyroidism, neutrophilic leukocytosis with a shift to the right, lymphopenia, and decreased phagocytic activity of neutrophils were observed. Glyproline neuropeptides contributed to the correction of observed changes in white blood cell indices and phagocytic processes, which indicates the immunocorrigating effect of the test compounds. Thus, glyproline neuropeptides demonstrated pronounced immunotropic activity, which manifested in the correction of changes arising from the leukocyte count and phagocytosis processes. However, further detailed study of the pharmacological effects of neuropeptide agents on experimental hyperthyroidism is necessary.
全文:
![受限制的访问](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
作者简介
Mariyam Sergalieva
Astrakhan State Medical University
编辑信件的主要联系方式.
Email: charlina_astr@mail.ru
ORCID iD: 0000-0002-9630-2913
SPIN 代码: 7976-9321
candidate of biological sciences
俄罗斯联邦, AstrakhanAlexandra Tsybizova
Astrakhan State Medical University
Email: sasha3633@yandex.ru
ORCID iD: 0000-0002-9994-4751
SPIN 代码: 2206-3898
Scopus 作者 ID: 57170924200
candidate of pharmaceutical sciences
俄罗斯联邦, AstrakhanLyudmila Andreeva
Kurchatov Institute — Institute of Molecular Genetics
Email: landr@img.ras.ru
ORCID iD: 0000-0002-3927-8590
SPIN 代码: 4785-5621
Scopus 作者 ID: 7102725159
head of the sector
俄罗斯联邦, MoscowNikolay Myasoedov
Kurchatov Institute — Institute of Molecular Genetics
Email: nfm@img.ras.ru
ORCID iD: 0000-0003-1294-102X
SPIN 代码: 1262-2698
Scopus 作者 ID: 7005093383
doctor of chemical sciences, professor
俄罗斯联邦, MoscowOlga Bashkina
Astrakhan State Medical University
Email: bashkina1@mail.ru
ORCID iD: 0000-0003-4168-4851
SPIN 代码: 3620-0724
Scopus 作者 ID: 6503961642
doctor of medical sciences, professor
俄罗斯联邦, AstrakhanMarina Samotrueva
Astrakhan State Medical University
Email: ms1506@mail.ru
ORCID iD: 0000-0001-5336-4455
SPIN 代码: 5918-1341
Scopus 作者 ID: 8221221300
doctor of medical sciences, professor
俄罗斯联邦, Astrakhan参考
- Taylor PN, Albrecht D, Scholz A, et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol. 2018;14(5):301–316. doi: 10.1038/nrendo.2018.18
- Doubleday AR, Sippel RS. Hyperthyroidism. Gland Surg. 2020;9(1):124–135. doi: 10.21037/gs.2019.11.01
- Lane LC, Cheetham TD, Perros P, Pearce SHS. New Therapeutic Horizons for Graves’ Hyperthyroidism. Endocr Rev. 2020;41(6): 873–884. doi: 10.1210/endrev/bnaa022
- Rivas AM, Pena C, Kopel J, et al. Hypertension and Hyperthyroidism: Association and Pathogenesis. Am J Med Sci. 2021;361(1):3–7. doi: 10.1016/j.amjms.2020.08.012
- Tsai K, Leung AM. Subclinical Hyperthyroidism: A Review of the Clinical Literature. Endocr Pract. 2021;27(3):254–260. doi: 10.1016/j.eprac.2021.02.002
- Noda M. Thyroid Hormone in the CNS: Contribution of Neuron-Glia Interaction. Vitam Horm. 2018;106:313–331. doi: 10.1016/bs.vh.2017.05.005
- Chenchak VA. Features of the action of thyroxin on the immune system. 2017;(3):38–38. (In Russ.).
- Zenkov AL. O vliyanii tiroksina na immunokompetentnye kletki. International Conference on Chemical, Biological and Health Sciences. Pisa, 2017. P. 117–128. (In Russ.).
- Carr R, Frings S. Neuropeptides in sensory signal processing. Cell and Tissue Res. 2019;375(1):217–225. doi: 10.1007/s00441-018-2946-3
- Yasenyavskaya AL, Samotrueva MA, Myasoedov NF, Andreeva LA. Influence of semax on the level of interleukin-1βin the conditions of “social” stress. Medical academic journal. 2019;9(1S): 192–194. (In Russ.). doi: 10.17816/MAJ191S1192-194
- Vyunova TV, Andreeva LA, Shevchenko KV, Myasoedov NF. An integrated approach to study the molecular aspects of regulatory peptides biological mechanism. J Label Compd Radiopharm. 2019;62(12):812–822. doi: 10.1002/jlcr.3785
- Thiele TE. Neuropeptides and Addiction: An Introduction International. Rev Neurobiol. 2017;136:1–3. doi: 10.1016/bs.irn.2017.07.001
- Sergalieva MU, Tsibizova AA, Abdulkadyrova EI. The effect of selank and pro-gly-proon behavioral responses white rats in the Porsolt test in the conditions of experimental hyperthyroidism. Astrakhan medical journal. 2021;16(2):53–61. (In Russ.). doi: 10.17021/2021.16.2.53.61
- Shcherba VV, Korda MM. The state of the nitrogen (II) oxidesystem in rats with periodontitis on the background of hyper- and hypothyroidism. Medical and Clinical Chemistry. 2018;2(1):143. (In Ukraine). doi: 10.11603/mcch.2410-681X.2018.v0.i1.8844
补充文件
![](/img/style/loading.gif)