Vol 7, No 2 (2010)
- Year: 2010
- Articles: 31
- URL: https://journals.eco-vector.com/1994-9480/issue/view/6225
Articles



SICKLY CHILDREN: PROBLEMS AND WAYS OF SOLVING THEM
Abstract
The problem of rehabilitation of frequently ailing children is not yet elucidated despite much research done in this field.
The authors analyze up-to-date views of etiopathogenicity of this pathology. An algorithm of treatment and prophylaxis of
acute respiratory diseases is proposed for this group of children.
Journal of Volgograd State Medical University. 2010;7(2):9-13



INFLUENCE OF LONG TERM THERAPYWITH SULPHONYLUREA DERIVATIVESON THE CAPACITY OF THE HEPATIC CYP2C9ENZYME SYSTEM OF DRUG BIOTRANSFORMATIONIN DIABETIC TYPE II PATIENTS IN THE CITYOF VOLGOGRAD
Abstract
It is shown that long-standing type II diabetes mellitus leads to the reduced CYP2C9 capacity. There has been
obtained strong evidence that long term administration of sulphonylurea derivatives reduces the CYP2 C9 capacity by
significantly altering pharmacokinetics of the drugs. This requires a change in their dosing regimen . Mandatory
pharmacokinetic typing of CYP2C9 activity should be recommended to improve the efficacy of pharmacotherapy for type II
diabetes mellitus, to prevent the undesirable adverse reactions when taking the drugs and to reduce the treatment cost for
this group of patients.
Journal of Volgograd State Medical University. 2010;7(2):14-18



DEVELOPMENT OF METHODOLOGY PROGNOSTICATIONOF DRUGS CONSUMPTION FOR TREATMENTOF THE BRONCHIAL ASTHMA BY MEANS OF THEPHARMACOEPIDEMIOLOGICAL ANALYSISON THE BASIS OF THE PERSONIFIED ACCOUNT DATA
Abstract
Analysis of morbidity processes of bronchial asthma and concomitant diseases by personified account data of
patients and results of pharmacoepidemiological analysis enabled us to construct a prediction model of the cost of
treatment of bronchial asthma. The model considers growth incidence rate and the amount of consumed drugs.
Journal of Volgograd State Medical University. 2010;7(2):19-21



MODERN APPROACHES TO DIAGNOSTICS OF PATHOLOGICAL CONDITIONSIN NEWBORNS
Abstract
An increase in morbidity of newborns is observed over recent years. In most cases metabolic disorders, levocarnitin
deficiency in particular as it is hardly produced in late neonatal period, underlie their pathogenesis. The structure of
cardiovascular diseases in the neonatal period is dominated by an increase in the rate of consequences of perinatal
hypoxic lesions of the myocardium in the form of transient ischemia. This study proposes modern approaches to diagnostics
and treatment of transient myocardial ischemia in newborns, to estimation of the level of arterial p ressure in preterm
newborns using the AMBP method.
Journal of Volgograd State Medical University. 2010;7(2):21-24



CLINICAL AND LABORATORY ASPECTSOF ABDOMINAL SEPSIS
Abstract
This work analyses the clinical presentation, general clinical, immunological and biochemical changes in 129 patients
with abdominal sepsis. 6 main indicators have been associated with abdominal sepsis - primary and secondary source
of infection, anaemia without blood loss, one of the five types of temperature pattern, reduced immune status, multiple
organ dysfunction and the presence of peritonitis.
Journal of Volgograd State Medical University. 2010;7(2):25-28



DEVELOPMENT OF A METHOD FOR QUANTIFICATION BIOGENE AMINES AND THEIR METABOLITES IN RATS BRAIN STRUCTURES
Abstract
Analysis of the low levels of biogenic amines and metabolites in tissue and biological fluids has necessitated the use
of highly sensitive analytical techniques. W e describe a sensitive, simple and selective high-perfor mance liquidchromatographic
method for measuring noradrenaline, dopamine, serotonin, 3,4-dihydroxyphenyl acetic acid, 5-hydroxyindolacetic
acid in brain tissue of rats.
Journal of Volgograd State Medical University. 2010;7(2):29-31



THE AUTOMATED SYSTEM OF MONITORING MEDICAL AID QUALITYIN IN-PATIENT MEDICAL INSTITUTIONS
Abstract
A model monitoring the quality and technology of rendering medical aid in a hospital by means of an automated
information system is presented. The results of examination of quality of rendering medical aid in in-patient medical
institutions in the Volgograd city for the period of 2008 and 2009 are analyzed.
Journal of Volgograd State Medical University. 2010;7(2):31-33



STUDY OF IMMUNOREACTIVITYIN PATIENTS WITH CHRONIC PROSTATITISAND PROSTATE CANCER
Abstract
Immunoreactivity in patients with chronic prostatitis and prostate cancer was studied; possibility of applying blood
leukocytic formula parameters for the purpose of revealing secondary immunodeficiency state are considered.
The absence of reaction in the form of IgM level increase in patients with chronic prostatitis indicates the presence of
immune deficiency in formation of antibacterial or antiviral antibodies, which can be the direct cause of chronization supporting
the chronic inflammation process.
Journal of Volgograd State Medical University. 2010;7(2):34-36



PHARMACOEPIDEMIOLOGIC STUDYOF DRUG THERAPY OF CHRONIC URTICARIAIN ADULTS IN VOLGOGRAD
Abstract
The article presents results of regional pharmacoepidemiologic research of chronic urticaria drug th erapy. The
analysis of therapy reveals insufficient antiallergic knowledge of rational pharmacotherapy of urticaria among doctors.
Journal of Volgograd State Medical University. 2010;7(2):37-40



CHANGES OF SOME INDICATORSOF IMMUNE STATUS IN PATIENTS WITH FOCALHEPATIC LESIONS
Abstract
When pathological processes develop in the body, various changes in immune status arise. These chang es are
manifested by impairment of the functional activity of individual units of the immune system, imbalance of antiinfectious
humoral immunity. Some immunity indicators in patients with asymptomatic focal formations in the liver are studied. A
complex estimation of cellular and humoral immunity with the analysis of subclasses of lymphocytes, major classes of
immunoglobulins, circulating immune complexes, phagocytic level was carried out.
Journal of Volgograd State Medical University. 2010;7(2):41-45



24-HOUR AMBULATORY BLOOD PRESSURE MONITORING PECULARITIESAND VARIABILITY OF HEART RATE IN ARTERIAL HYPERTENSION IN PATIENTSWITH SECONDARY CHRONIC PYELONEPHRITIS
Abstract
Our study found that patients with arterial hypertension (AH) and secondary chronic pyelonephritis revealed more
pronounced changes in 24-hour ambulatory blood pressure monitoring, reduced heart rate variability compared with the
group of patients with essential hypertension.
Journal of Volgograd State Medical University. 2010;7(2):46-48



CLINICOIMMUNOLOGICAL FEATURES OF ATYPICAL MAXILLOFACIAL PHLEGMONS
Abstract
Investigation and treatment of 22 patients with atypical phlegmon of maxillofacial area was carried out. The immune
status of patients was characterised by a high activity of the local immunity link and somewhat weak activation of general
immunity. Development of postinfectious immune insufficiency primarily involving the phagocytic compartment of local
immunity was the feature of immunity in torpid maxillofacial phlegmon. There is a correlation dependence of all links of the
immune status parametres changes of the body.
Journal of Volgograd State Medical University. 2010;7(2):49-51



PSYCHOPHYSIOLOGICAL ASPECTS OF DEVELOPMENTOF CHRONIC PAIN SYNDROMES
Abstract
The paper presents data on the influence of pain beliefs on the development and therapeutic resistance of chronic
pain syndromes. A need for further investigation of patients pain beliefs so as to increase the efficiency of treatment was
showed.
Journal of Volgograd State Medical University. 2010;7(2):52-54



TREATMENT OF PHLEGMONS OF SOFT TISSUES USING ENDOSCOPICAND HYDROPRESSIVE TECHNOLOGIES
Abstract
An analysis of treatment of patients with phlegmons of soft tissue with visualised endoscopic hydropressive sanation
and programmed drainage was carried out. An algorithm of managing patients taking into account the features of pathological
process is proposed.
Journal of Volgograd State Medical University. 2010;7(2):54-57



DISTURBANCES OF HORMONAL STATUS IN WOMEN OF REPRODUCTIVE AGEWITH TENSION HEADACHE
Abstract
Results of studying a possible pathogenic correlation of tension headache and functional status of h ypophysialovarian
system in women of reproductive age have been presented. 100 women with chronic tension headache and 30
women with episodic tension headache have been examined. It has been demonstrated that in case of chronic tension
headache a marked imbalance of sex hormones and cortisol dependent on the phase of menstrual cycle is present. On the
basis of the obtained data pathogenic correlation of chronic tension headache and hormonal deviations is considered.
Journal of Volgograd State Medical University. 2010;7(2):58-60



QUALITY OF LIFE OF PREMATURE INFANTS WITH POST-CEREBRAL ISCHEMIA
Abstract
The aim of the present study is to assess the quality of life of premature infants with posthypoxiс lesion of the central
nervous system. The study was conducted using the QUALIN questionnaire. It was found that in premature infants with
post-cerebral ischemia the quality of life is lower than in their healthy peers.
Journal of Volgograd State Medical University. 2010;7(2):61-63



NEW APPROACHES TO MANAGING PREGNANT WOMENWITH PLACENTAL INSUFFICIENCY
Abstract
For optimization of management of pregnant women group of high risk for placental insufficiency a clinical algorithm
is proposed that was developed for a modified scale of diagnostics of placental insufficiency. For d evelopment of the
algorithm and its approbation in clinical conditions, 1192 pregnant women and their newborns were observed. The analysis
of the condition of newborns has shown favorable perinatal outcomes upon managing pregnant women according to the
developed clinical algorithm.
Journal of Volgograd State Medical University. 2010;7(2):64-67



SURGICAL TREATMENT OF EXTRASPHINCTERIC RECTUM FISTULAS
Abstract
The purpose of this study is to evaluate a new method of fistula excision by means of U-shaped ligature loop running
on a needle along the sphincter fibers. 130 patients with extrasphincteric rectum fistulas were operated, 61,5 % of them with
a fistula of 3-4 degree of complication. The method was worked out and applied to 38 patients. In comparison with a
control group the number of recurrence was two times lower, and the treatment period was twice shortened in the absolute
absence of insufficiency rectum sphincter.
Journal of Volgograd State Medical University. 2010;7(2):68-70



PROCESSING OF CONTAMINATED SURGICAL WOUND WITH ANTISEPTICSOLUTION IN APPENDECTOMY THROUGH MINI-ACCESS
Abstract
Microbial contamination of abdominal cavity and wound before and after processing it with antiseptics was studied.
Microorganisms were isolated from a surgical wound and identified for their morphological, tinctoria l, enzymatic and
antigen properties with a bacteriological method. Efficiency of processing of a surgical wound with various antiseptics is
estimated. Upon processing of a surgical wound with 0,5 % water-alcohol solution, 70 % solution of chlorhexidine digluconate
with a 1-2 minute exposition the results were negative in 19 patients. The results of microbiological research were
negative in 100 % cases.
Journal of Volgograd State Medical University. 2010;7(2):71-73



INVALIDS LIFE QUALITY
Abstract
The article presents information a study conducted in the Krasnodar region for determination of life quality of the
invalids. The investigation was done using international methodology, which opens new possibilities for complex estimation
of health and life quality of invalids.
Journal of Volgograd State Medical University. 2010;7(2):74-77



DEFINITION OF OBJECTIVE CRITERION OF ENDURANCE FOR DIAGNOSTICSOF HEALTH IN THE HEALTHY
Abstract
On the basis of the analysis of ergometric, regenerative and stationary parameters of practically healthy volunteers an
objective (numerical) criterion of endurance is proposed. A study of its prognostic and diagnostic value revealed some
regularities of endurance development thus allowing us to use this criterion for objective evaluation of health.
Journal of Volgograd State Medical University. 2010;7(2):78-82



MICROBIOCENOSIS OF A VAGINA IN MODERN ALMOST HEALTHY WOMENOF YOUNG REPRODUCTIVE AGE
Abstract
This paper presents the results of microbiological analysis of vaginal ecosystem of 60 practically healthy women in
their early reproductive age. It is established that the stability of vaginal ecosystem in conditions of the changed way of life
of modern women is defined by not only simple quantitative prevalence of lactobacteria above other microorganisms, but
also by their specific features providing an increased synthesis of protective factors despite poorly represented lactobacteria.
Journal of Volgograd State Medical University. 2010;7(2):83-87



СHANGE OF BACTERIA CATALASE ACTIVITY AT ELECTROMAGNETIC RADIATIONAT FREQUENCY OF THE MOLECULAR SPECTRUM OF ABSORPTIONAND RADIATION OF ATMOSPHERIC OXYGEN
Abstract
Dynamics of change in the level of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa catalase
activity is described at E-field radiation at the frequency of atmospheric oxygen molecular spectrum of absorption and
radiation. An increase of enzyme activity in the studied cultures is revealed, which was most expressed at a 45-minute
exposition.
Journal of Volgograd State Medical University. 2010;7(2):87-89



MODERN WAYS OF TREATING COMPLICATED FORMS OF CHRONIC VENOUSINSUFFICIENCY OF LOWER EXTREMITIES
Abstract
Trophic skin lesions of lower extremities in patients with chronic venous insufficiency is a serious surgical problem.
The results of comparative investigations of 65 patients with venous trophic ulcers are showed. In conservative treatment
and postoperative applications of dermal fibroblasts, culture of wound covering «Voskopran» was used. This method is
efficacious and greatly promotes the healing of trophic ulcers.
Journal of Volgograd State Medical University. 2010;7(2):90-93



CALCIUM АNTAGONISTS AND UROLITHIASIS: NEW PERSPECTIVES
Abstract
In view of the exclusive role of ions of calcium in regulation of numerous functions of tissue and cells of the body, great
importance is assigned to preparations of calcium antagonists (СА). CA were first applied exclusively in cardiology, but
owing to their properties they have found application in obstetrics, gynecology, neurology, immunology, surgery. Despite
numerous experimental studies testifying to the expressed cardiovascular properties of CA, indications for their administration
constantly expand, which is associated with the physiological role of ions of calcium in providing for vital activity of cells and
the whole body. Preliminary results indicate that СА can be administered in new ways - as modulators of apoptosis in renal
tissue in urolithiasis and chronic pyelonephritis.
Journal of Volgograd State Medical University. 2010;7(2):93-96



BLOOD AND URINE CYTOKINES DYNAMICS IN PERIOPERATIVE PERIODIN CHILDREN WITH VESICOURETERAL REFLUX
Abstract
Results of blood and urine cytokines (IL-1betta, 6, 8, the FNO-alpha, 4,10) study in 40 children with vesicoureteral
reflux in perioperative period are described in this article. It is revealed that even in the latent phase of chronic obstructive
pyelonephritis there are expressed changes of cytokines profile in urine. It is shown that a change in the level of proinflammatory
IL 8 and 6 is of the greatest prognostic value, which has a strong positive correlation with severity of inflammatory process
in urinary tracts. We assume that a study of urine cytokines profile provides a noninvasive method for estimation of the
severity of inflammatory process in urinary tracts, efficiency of administered conservative therapy, as well as a correction in
the terms of carrying out operative interventions, which is especially important in young children.
Journal of Volgograd State Medical University. 2010;7(2):97-99



CHANGES OF LEUKOCYTES LEVEL AND LEUKOCYTE FORMULA IN PATIENTSWITH SYSTEMIC LUPUS ERYTHEMATOSUS DEPENDING ON THE CLINICALCOURSE AND CHARACTER OF THERAPY
Abstract
The level of leukocytes and leukocyte formula both in a disease onset, and upon admission to hospital were studied.
It is revealed that the level of leukocytes in patients with systemic lupus erythematosus is closely interconnected with the
activity of the disease, exudative nature of internal lesion, extent of haemolysis. However, no interrelations with a total dose
of cyclophosphan was established, which testifies to a mostly immune genesis of leukopenia. We should underline the
prognostic value of leukocytes decrease in the onset of a disease, which is associated with severe clinical manifestations
of systemic lupus erythematosus.
Journal of Volgograd State Medical University. 2010;7(2):100-103






FEATURES OF INTELLECTUAL PROCESSES PROVIDING FOR OPERATORS ACTIVITY
Abstract
The present work is devoted to investigation of the role of intelligence in effective work of operators of sensomotor
profile in a man-machine system. A short characteristic of the intellectual processes providing for operators activity is
proposed. An analysis of mutual influences of indicators of emotional and psychometric intelligence is done. A comparison
of isolated types of emotional and psychometric intelligence is made. Specifics of operators intellectual sphere are shown.
It is demonstrated that a high level of emotional and psychometric intelligence is the integral component of an effective
operators activity.
Journal of Volgograd State Medical University. 2010;7(2):110-112



RESPIRATORY DISEASES OF HIV-INFECTED PATIENTS
Abstract
Brief information on diagnostics and treatment of the most common respiratory secondary diseases in HIV-infected
patients is presented in the article. The diseases are pulmonary tuberculosis, bacterial pneumonia, viral herpetic pneumonia
and pneumocystic pneumonia.
Journal of Volgograd State Medical University. 2010;7(2):113-116


