Pharmacy Formulas

A periodical scientific publication, the journal " Formulas of Pharmacy "(hereinafter-the publication), for publishing the main scientific results of dissertations for the degree of candidate of Sciences, for the degree of doctor of Sciences; presents high-quality, peer-reviewed research and interactive clinical content.

Our journal is focused on clinical pharmacologists, specialists of expert organizations, workers centers preclinical and clinical trials of medicinal products; employees of regulatory and Supervisory organizations and institutions in the field of pharmaceutical industry and Russian Ministry of health; researchers, medical and pharmaceutical workers of the organisations and institutions of the Ministry of health; experts of the scientific organizations of RAS and other researchers in the field of environmental security.

The topics of published materials are limited to two branches of science - medical and biological - and they correspond to groups of scientific specialties (03.02.00 General biology, 14.03.00 Biomedical sciences, 14.04.00 Pharmaceutical sciences) in accordance with the order of the Ministry of Education of the Russian Federation dated October 23, 2017 No. 1027 "On the approval of the nomenclature of scientific specialties for which science degrees are awarded" and by order of the Ministry of Education and Science of the Russian Federation of December 12, 2016 No. 1586 (revised March 27, 2018) "On the approval of the rules for forming the list of peer-reviewed scientific publications."

The publication complies with modern rules and requirements of domestic and foreign legislation for peer-reviewed scientific publications.

Journal strategy

When preparing each issue, members of the editorial Board intend to take into account modern requirements for the order of qualified review, information openness and bibliometric indicators in assessing the publication activity of authors, along with other factors of the journal.

To this end, the editorial team uses rigorous: editorial, expert, and statistical review processes to evaluate manuscripts for scientific accuracy, novelty, and importance; policies and practices that ensure that authors disclose all relevant financial associations and that such associations do not in any way affect the content published by the journal.

When developing the strategy and layout of the publication, we studied and analyzed the professional materials available to us from information resources of publishers and owners of bibliographic and abstract databases-leaders of international citation systems for relevant branches of science and groups of scientific specialties.

In the course of this work, three groups of scientific specialties were identified, which, in our opinion, made it possible to create a publication's rubricator and determine its name: "Pharmacy Formulas". At the same time, we took into account the definition of pharmacy as the entire life cycle of medicines, including the creation, preclinical and clinical research, production technology, organization of pharmaceutical business, as well as issues of control and analytical research, food and environmental safety. In turn, the word "formulas" means directions, trends, trends in the development of scientific and practical areas that make up pharmacy.

We believe that through our efforts, the journal will keep healthcare and pharmaceutical industry professionals at the forefront of medical and pharmaceutical knowledge, help them deepen their understanding of new areas of interest, and provide valuable insights into scientific and practical medical and pharmaceutical activities.

Authors and readers

To present the results of high-quality scientific research to the reader, we are ready to be responsible for preparing the manuscript to meet the requirements of the journal, quality review of manuscripts , preparing the article for publication, providing opportunities and scientific communications of the founders of the publication to promote the article.

The journal's website meets all the requirements of the international bibliographic database. Full electronic document flow for authors, reviewers, scientific and literary editors is carried out on our own platform.

To promote the article, authors will be able to use the personal website of the publication; assignment of the DOI identifier of the author's manuscript immediately after uploading to the site; unique author ID ORCID; professional social networks Google Scholar, ResearchGate; repositories; open electronic archives; bibliography management system; social media; registration of the scientist as a reviewer; assistance in preparing the use of media (materials for press releases, interviews).

The publishing house of the journal has direct channels for transmitting information to the RSCI and international databases: Scopus, Web of Science, PubMed, CNKI.

When developing all the tasks facing the members of the editorial Board and editorial Board of the journal "Formulas of Pharmacy", we share a common goal: to promote and actively participate in scientific communications on the declared groups of scientific specialties in the biomedical field and pharmacy, from the idea to the release of medicines to the consumer market and management of their waste and metabolites.

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Current Issue

Vol 3, No 1 (2021)

From the editor
From the editorial Board
Narkevich I.A., Perelygin V.V.
Pharmacy Formulas. 2021;3(1):8-9
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Pharmaceutical Sciences
Docking of highly selective 5HT2A/C-receptor peptide ligands with antipsychotic activity
Orlova A.B., Sventitskaya A.M., Vengerovich N.G., Nikiforov A.S., Ivanov I.M., Proshina Y.A.
Abstract

Search for new ligands selective to different subtypes of 5HT2-receptors is an important scientific and practical problem for experimental psychopharmacology and clinical medicine. The majority of existing antagonists of the 5HT2A- and 5HT2C- subtypes possess all necessary anti-anxiety and antipsychotic properties, though they are partially selective to 5HT2B receptors. Their activation leads to cardiotoxic side effects, so it significantly limits clinical application of these drugs.

For the search of new highly selective ligands of 5HT2A/C- receptors, an in silico screening algorithm was proposed using PScore.Max and Affinity.maxPScore parameters, which included the affinity of low molecular weight compounds for each 5HT2-receptor subtype. Cyclic physiologically active substances of peptide nature have been proposed as new promising drugs with antipsychotic activity. Based on the CXXC library, a number of cyclopeptides with a high selectivity of structure to target binding sites were selected for further in vitro studies by extending of the peptide chain.

It was also found that a promising direction for increasing the selectivity of peptide ligands to 5HT2A/C- receptors is the introduction of non-proteinogenic amino acids during the formation of an initial docking library. The choice of these amino acids will be due to the nature of interactions between the reference ligands and amino acid residues of the binding site.

Pharmacy Formulas. 2021;3(1):10-17
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The original action plan for the new drug preparationby a pharmaceutical manufacturer. Stage 2: Transfer of technologies
Bacevich A., Dzjuba A.S., Kaukhova I.E., Tretiakov A., Sakharov V.A.
Abstract

The paper presents the results of the study based on the guidelines and scientific data on the technology transfer in the circulation of drugs. The initial data for calculations, assessment and analysis of the study results were taken from the current documentation at the operating production site of the pharmaceutical manufacturer with the participation of the company officials. The data was collected from the company work papers and job descriptions following interviews with a group of unit staff involved in the technology transfer.

The summary and the analysis of the data obtained during the research on the technology transfer for the preparation of new drugs were implemented. It was used to construct Gantt charts for some critical processes. Theassessment of the criticality of individual stages of technology transfer and a control chart of the project manager, indicating the control points of this process, was presented.

Hence, the original action plan for the new drug preparation by a pharmaceutical manufacturer has been developed: risk control and assessment system for the technology transfer project activities has been determined to assess the degree of criticality of deviations, both for the individual stages and the entire technology transfer project.

According to the objectives of the study, an original action plan for the new drug preparation by the pharmaceutical manufacturer based on the collection, processing and analysis of the data on the technology transfer at the manufacturing site has been developed.

If required, the original action plan may be tested by other drug manufacturers in the pharmaceutical industry.

Pharmacy Formulas. 2021;3(1):18-30
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The significance of the original characteristics of the active substance of injectable chondroitin sulfate preparations for intramuscular injections in the evidence-based medicine
Napalkova S.M., Okovityi S.V., Ivkin D.Y., Pyatibrat A.O.
Abstract

Given the data from normative control resources and the research and development   information system of the Ministry of Science and Education of the Russian Federation, we were unable to review the results and the quality of publications comprising method development and analytical validation of quantitative and qualitative values of injectable chondroitin sulfate preparations for intramuscular injections.

Therefore, the results obtained in the research “The development of a method for determining the intrinsic viscosity of an injectable chondroitin sodium sulfate preparation for intramuscular injections of 100 mg/ml, 2 ml” remain valid, the method is considered reliable and practical.

The materials and methods used in the research “The development of a method for determining the intrinsic viscosity of an injectable chondroitin sulfate preparation” have provided the possibility to determine the intrinsic viscosity for injectable chondroitin sodium sulfate preparations for intramuscular injections and the use of 0.2 M sodium chloride solution as a solvent. Also, the viscosity of the tested solutions in the concentration range of chondroitin sulfate 4.5-20 mg/ml was accurately сalculated, the value of the intrinsic viscosity determined for each of the preparations under test was in the range of 0.03-0.042 m3/kg.

This study presents the results of a review of recent information, published in a number of academic journals, concerning modern approaches to the treatment and major clinical problems when applying chondroprotectors for arthrological diseases treatment. 

Considering the continuing interest in chondroprotectors, stability problems with formulations and modern possibilities in the application of machine learning in drug discovery, additional pharmaceutical design research (Drug design) is expected - from the docking stage to the quantum calculations stage.

Pharmacy Formulas. 2021;3(1):32-45
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Biomedical Sciences
Stages of development of the system of objective assessment of the cancer service of Russia, the northwestern Federal district of the Russian Federation (morbidity, mortality, reliability of accounting, primary mortality, median survival, observed and relative survival of patients with malignant neoplasms). Part I.
Merabishvili V.M., Belyaev A.M.
Abstract

The first part of the study includes a brief historical outline on the creation of an objective system for assessing the activities of the oncological service in Russia and the Northwestern Federal District of the Russian Federation.Dynamic series of all types of indicators of the population’s morbidity and mortality have been presented, an increasing process of reliability and improvement of the quality of registration of primary patients with malignant tumors has been shown.In Russia, aswell as in the Northwestern Federal District of the Russian Federation, standardized indicators of the malignant tumorsincidence remain at a relatively low level. In the world ranking of Cancer Registries, the Russian Federation is on 300th place among 450 others.The mortality rate of the population in most localizations isrecorded above the average European indicators.

Pharmacy Formulas. 2021;3(1):46-55
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Stages of the objective assessment system development for the activities of the oncological service in Russia and the Northwestern Federal District of the Russian Federation (morbidity, mortality, index accuracy, annual mortality, median survival, observed and relative survival of patients with malignant tumors). Part II
Merabishvili V.M., Belyaev A.M.
Abstract

To plan anti-cancer measures and to correctly manage its condition, it is necessary to use only reliable sources of its formation. For this purpose, a system of Population-based or territorial Cancer Registries (PCR) has been created in Russia. The first Registry was the St. Petersburg PCR, created by us in 1993, which became the school of methodological preparation of the system in the administrative territories of Russia. The corresponding Order No. 420 of April, 19, 1996 issued by the Ministry of Public Health of the Russian Federation has legitimized a new organizational structure and entrusted it with the supervision of the P. Hertsen Moscow Oncology Research Institute.

Unfortunately, to date, the PCR databases are not used, when creating state reports, analytical developments on the PCR database are either not conducted, or are used extremely rarely. The only exception was the St. Petersburg PCR, and now the entire Northwestern Federal District of the Russian Federation (NWFD RF) and 6 more administrative territories operating under our programs. The materials of the real state of the oncological service, prepared on the basis of the St. Petersburg PCR database, have been published by us in more than 20 monographs in St. Petersburg and the Northwestern Federal District of Russia.

In this paper, we present the dynamics of analytical indicators calculated according to the PCR database, which sharply differ from the data of the Form No. 7 Annual Reports. The calculated indicators are close to the European average and have a positive trend.

Pharmacy Formulas. 2021;3(1):56-65
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Comparison of the effectiveness of supplementary prescribing the chonodoprotector Mucosat in the oral and parenteral dosage forms during the acute exacerbation of osteoarthritis
Peshekhonova L.K., Peshekhonov D.V., Pyatibrat A.O., Vengerovich N.
Abstract

The study aims to compare the methods of Mucosat drug use and administration for achieving the desired therapeutic effect in the treatment of osteoarthritis.

Despite extensive evidence base, improving complex therapy schemes for the use of successive and complementary dosage forms with the appropriate drug administration and use in order to achieve the desired therapeutic effect is still a valid aim.

In the course of the study, 50 knee osteoarthritis patients were examined and treated during the period from November, 2019 to April, 2020.

A clinical trial was carried out to assess Mucosat oral and parental administration effectiveness in the patients comparing their physical activity, functional ability and quality of life. The number of undesired side effects identified the degree of therapeutic tolerance against the comorbid diseases identified. A comparison of the therapeutic efficacy and tolerability of Musocat intramuscular and capsule administration, patient compliance, the need to take non-steroidal anti-inflammatory drugs (NSAIDs) was drawn.

Statistica 12 and Excel 2016 were used to carry out the statistical analysis of the data obtained. The study was generally marked by diagnostic accuracy with the use of modern methods, group homogeneity, prospective observational design.

By the time of pharmacotherapy completion, physical activity has become optimal in the study groups. However, parental therapy had significantly higher effectiveness than the oral one on all the subscales. As a result, articular syndrome severity has been reduced and the functional state of the joints expanded.

The study has shown that Mucosat demonstrates high efficacy both in injectable solution and capsule dosage forms as a basic chondroprotective drug. Mucosat pharmacotherapy course has contributed to permanent discontinuation of NSAIDs before completion of the therapy. The superiority of Mucosat parenteral administration over the oral one has been proven.

Pharmacy Formulas. 2021;3(1):66-75
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Dementia in elderly patients as a consequence of arterial hypertension (literature review)
Mikhailov S.S., Kozlov K.L., Shishkevich A.N., Bessonov E.Y., Lukjanov N.G., Puhal'skaja A.E.
Abstract

Alzheimer's disease and vascular dementia are important causes of cognitive decline in the elderly and senile. This problem is becoming increasingly important in connection with the general aging of the world population and an increase in the number of patients with concomitant pathology, among which arterial hypertension plays an important role. There are a number of studies proving the link between arterial hypertension in middle age and dementia in the elderly. It is hoped that the normalization of blood pressure among middle-aged people will reduce the incidence of cognitive dysfunction. It is also known that maintaining blood pressure at acceptable levels in elderly and old people can improve brain function and reduce the prevalence of dementia, but it is not entirely clear which blood pressure numbers are optimal.

Pharmacy Formulas. 2021;3(1):76-83
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Biological sciences
COMPARATIVE BIOELECTRONIC DIAGNOSTICS OF THE ECOLOGICAL STATE OF POLLUTED WATER AREAS (ON THE EXAMPLE OF SOME CHANNELS OF THE VOLGA DELTA)
Kholodkevich S.V., Motruk M.K., Lyubimtsev V.A., Susloparova O.N.
Abstract

The objects of bioindication of the ecological state were 3 channels of the Volga Delta, located both directly in Astrakhan and in the Astrakhan region. The aim of the work was to conduct a comparative bioelectronic diagnosis of the ecological state of the selected channels with different local anthropogenic loads, both by type and size, based on assessments of the functional state (health) of the bivalve mollusks Anodonta anatina living in them, estimated on the basis of an analysis of their cardiorhythm, measured using an original fiber-optic bioelectronic system. It was found that shellfish selected from different water areas, after 1–hour functional load, restore the original heart rate for different times, but in the range from 117 to 166 minutes, which is typical for shellfish living in significantly polluted reservoirs of the same ecological status - "Bad". This characteristic of the water areas completely coincides with the characteristic of the ecological state of the channels of the Volga River Delta specified in the State Report "On the state and on Environmental Protection of the Russian Federation in 2017". The authors proposed and justified the possibility of using the water area of the Gandurino River as a conditional reference for the Volga Delta region. In this case, according to the value of the environmental quality coefficient EQR, the channels of the Urban Branch and the Small Channel can be attributed to the regional environmental status - "Good".

Pharmacy Formulas. 2021;3(1):84-91
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Investigating the effects of Inonotus rickii extracts on the muscle contraction intensity
Ranadive K.R., Jagtap N.V., Jagtap P.N., Zmitrovich I.V., Perelygin V.V.
Abstract

The aim of this study is to test the effect of aqueous, ethereal and alcoholic extracts of the fruit bodies of the wood-destroying fungus Inonotus rickii on locomotor activity resulting from contraction of both cross-striated and smooth muscles. The pharmacological activity of I. rickii raw materials was determined in vitro using the dose-response curve method (smooth muscles) and in experiments with oral intake of extracts (CNS-mediated effects on cross-lacing muscles). The aqueous extract of fungal material showed an increase in the motor activity of smooth muscles compared to standard caffeine, which indicates the ability of fungal extract to have a stimulating effect on the synapses. It was found that I. rickii extracts have an effect on smooth muscle contraction similar to the acetylcholine. It was shown that the greatest stimulating activity demonstrates an aqueous extract that may be a result of inhibitory effect of diethyl ether and ethanol on synapses. The described effects put on the agenda both the fractionation of active extracts and further experiments on the therapeutic applications of their described properties. As a field of possible application of this kind of substances can be considered the cardiovascular remodeling, the maintenance of smooth muscle tone during a number of surgical interventions, and the palliative cure of disseminated cancers.

Pharmacy Formulas. 2021;3(1):92-96
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Information and Prevention
Medical gas supply systems in the context of a pandemic
Kravchenko A.G.
Abstract

Medical gases have long been used in healthcare. After pipelines began to be used everywhere in the 50s of the last century instead of heavy and clumsy gas supply systems from high-pressure cylinders, it became an almost universal requirement for hospitals to have systems for supplying medical oxygen, carbon dioxide, nitrous oxide, air and providing medical vacuum.

Pharmacy Formulas. 2021;3(1):102-103
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Heritage
Pyotr Ivanovich Astrakhantsev: first post-war Director of the Leningrad Pharmaceutical Institute
Narkevich I.A., Stepanov S.V., Volgusheva A.O., Zvyagin Y.Y., Vorobeva S., Perelygin V., Dobrova D.
Abstract

There were several periods in the history connected with the rebuilding of the Saint Petersburg State Chemical and Pharmaceutical University, which is over a century old, due to certain events related to the fate of Russia. One of these periods came after the Great Patriotic War. Some students and teachers were evacuated, some joined front line troops, others stayed in besieged Leningrad to live and work. Part of the facilities was evacuated. Another part was destroyed and lost. It was necessary to start all over again.

Based on unpublished documents from Saint Petersburg archives, this paper reconstructs the biography of P.I. Astrakhantsev (1905–1961), a university graduate, chemist, the first post-war director of the Leningrad Institute of Pharmacy. His life path was connected with Alma Mater, as well as with the work in the leading chemical institution of the USSR – the State Institute of Applied Chemistry (at present the Russian Scientific Center of Applied Chemistry) – he also taught chemistry in the 1st Leningrad Medical Institute, Molotov Pharmaceutical Institute, All-Union Correspondence Forest Engineering Institute.

Pharmacy Formulas. 2021;3(1):104-110
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The role of scientists of the Department of Psychiatry of the S.M. Kirov Military Medical Academy in the development of domestic narcology and pharmacological methods of treating this pathology
Tchudinovskih A.G., Zvyagin Y.Y.
Abstract

The study covers the history of the formation and development of narcology in the Russian Empire and the USSR. The role of the heads and psychiatrists of the Department of Psychiatry and the Clinic of Mental and Nervous Diseases of the S.M. Kirov Military Medical Academy in the fight against alcoholism in the country and the organization of drug treatment was identified. Particular emphasis was laid on the work of Vladimir Mikhailovich Bekhterev, a prominent Russian and Soviet psychiatrist, neuropathologist, physiologist and psychologist, the founder of reflexology and pathopsychological direction in Russia. It was V.M. Bekhterev who did everything to reverse public views on alcoholism and transfer it from the category of moral turpitude to the status of the disease; he organized the research and treatment for alcoholic patients. This paper considers the aspects of scientific development of issues related to narcology by the staff and heads of the department. The priority of domestic psychiatrists in the theoretical justification and practical application of conditioned reflex therapy for alcoholism has been shown.

Pharmacy Formulas. 2021;3(1):112-119
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