Vol 6, No 1 (2024)

The loss of effectiveness of standard treatment methods and the increased risk of rapid spread of infections are serious consequences of this problem. This underscores the need to develop new approaches to combating pathogen resistance and ensuring effective control of infections. Studies of antimicrobial activity were conducted on strains of C. albicans, A. niger, and B. subtilis. The minimal fungicidal concentration was determined based on the growth of microorganisms C. albicans, A. niger on Sabouraud agar media containing different concentrations of a new substance - a derivative of thiadiazole. The sporicidal activity was determined by culturing the test culture B. subtilis in meat-peptone broth, followed by seeding on meat-peptone agar. Sporicidal activity was determined by inoculating the test culture of B. subtilis into meat-peptone broth, followed by plating on meat-peptone agar. Control assays were performed by inoculating the test cultures on corresponding media without the test substances. The new disinfectant - a derivative of thiadiazole - demonstrated high antimicrobial activity. The aim of this research was to study the new chemical substance for antimicrobial (antifungal and sporicidal) activity and the creation of new types of biocides. The studies showed that the minimum fungicidal concentration of the 0.3% solution in a 30% alcohol solution against C. albicans RCPGY401 was 1.56 ± 1.06 μg/mL, A. niger 137a - 1.56 ± 1.29 μg/mL. Furthermore, the material exhibited sporicidal activity against B. subtilis ATCC 10702, with an effective concentration of - 3.12 ± 1.34 μg/mL. The research confirms the activity of the new compound against the studied microorganisms and allows for its recommendation for further study (treatment regimens, safety, control methods, etc.) for use in veterinary practice for various treatment purposes.

Malignant neoplasms are considered among the most serious and prevalent diseases in many countries worldwide. In the course of our research, we conducted a review where we synthesized findings from five scientific articles providing detailed descriptions of age-related patterns of prevalence, structure, and survival among oncology patients. The final population-based study presents a culmination of all identified characteristics of this process, particularly regarding the role of age in the characteristics of prevalence and survival of cancer patients, which holds significant importance. The study utilized data from the International Agency for Research on Cancer (IARC), handbooks from the P.A. Herzen MNIOI and the N.N. Petrov National Medical Research Center of Oncology, as well as data from population-based cancer registries databases from the Saint Petersburg and Northwestern Federal District of Russia. Data processing was conducted using licensed software MS Excel 2013-2016 and STATISTICA 6.1. Modified Eurocare software, alongside mathematical, bibliographic, and statistical methods, was employed for survival calculations. The population-based study allowed for a detailed examination of the dynamics of age-specific indicators of morbidity, mortality, quality of initial patient management for MN, and survival rates of MN patients, consolidating vast datasets from across Russia and the Northwestern Federal District of Russia. All gathered and analyzed data indicate an enhancement in the quality of initial patient management for MN, a reduction in mortality rates, and an increase in survival rates.

The study is dedicated to the analysis of the cultural and medicinal plant Lavandula angustifolia Mill. from the Lamiaceae Martinov family. The plant is widely used in the food and perfume-cosmetic industries, as well as in traditional medicine for treating various diseases including rheumatism and migraines. The research focuses on the analysis of phenolic compounds and terpenoids, which are the main pharmacologically active components of narrow-leaved lavender. Phenolic compounds include flavonoids, phenolic acids, and coumarins, while terpenoids such as linalool and linalyl acetate are responsible for the aromatic essential oil. The experiment involved studying the quantitative content of flavonoids, chromatographic analysis of secondary metabolites, and microscopic analysis of the structure of narrow-leaved lavender flowers. The obtained data expand the nomenclature of pharmacopoeial herbal raw materials. The quantitative content of flavonoids and the profile of major polyphenolic secondary components have been established. These results can serve as a basis for standardization and quality assessment of narrow-leaved lavender flowers, as well as for further phytochemical and pharmacological research.

In the lecture, the significance of organizing the proper storage of various groups of pharmaceutical products in pharmacy institutions is discussed. The key principles and requirements for storing pharmaceutical products are illuminated, including maintaining the necessary temperature conditions, controlling humidity, tracking expiration dates, drug identification, as well as the peculiarities of storing light-sensitive and flammable medications. Special attention is given to the strict adherence to all established standards and procedures to ensure a high level of quality and safety in storing pharmaceutical products, in accordance with legislative requirements. Additionally, the lecture explores practical recommendations and current approaches to organizing the medication storage process to optimize the functioning of pharmacy organizations and to create conditions for safe and high-quality patient service.

The essay is dedicated to Nikolai Petrovich Elinov, an eminent scientist with a global reputation, who has made a substantial contribution to the development of medical microbiology, mycology, and biotechnology in the Russian Federation. N.P. Elinov is a professor, Doctor of Biological Sciences, Honored Scientist of the RSFSR, and rector of the Leningrad Chemical-Pharmaceutical Institute. He is an active member of the St. Petersburg Engineering Academy and the New York Academy of Sciences, author of 10 textbooks, 8 handbooks, 10 monographs, over 400 articles in domestic and foreign journals, and holds 70 patents for inventions. Professor N.P. Elinov is widely recognized in the scientific community for his work in areas such as biology of aposporous yeast, chemistry and biotechnology of microbial polysaccharides, and others. He has established a school of students and followers, including 50 candidates and 9 Doctors of Science. Under his guidance, the microbiology department laid the foundations for engineering and microbiological training of specialists. As the rector of LCFI, Nikolai Petrovich contributed to the organization of the country's only faculty for training biotechnology engineers, leading the university to top positions in preparing specialists for the pharmaceutical industry. In 1968, Nikolai Petrovich became a member of the International Commission on Yeast Organisms of the International Union of Microbiological Societies. His name was included in the book "2000 Outstanding Scientists of the Late 20th Century" (1998) by the Cambridge International Biographical Center (UK), where he was recognized as a specialist in microbiology and biotechnology. This essay, based on archival materials, publications, articles, and colleagues' memories, reveals the key milestones in the life and scientific achievements of Nikolai Petrovich Elinov.