Vol 6, No 3 (2015)

Diseases of the circulatory system are the major social problem worldwide. The prevalence of these diseases, disability, mortality, temporary disablement and the need for specialized medical care contribute to medical and social significance of this pathology, for which our society incurs tangible human and economic losses. According to experts, the number of deaths from CVDs will increase due to the increase of mortality among the male population from 18.1 million in 2010 to 24.2 million in 2030. Mortality rates from CVD in the Russian Federation - one of the highest in the world.

The anterior cruciate ligament (ACL) is most often structures to be damaged. In this research investigated biomechanics of walking at the timing, kinematics and dynamics parameters for 34 patients which had verified rupture of ACL. The 11 patients were investigated before surgical treatment and 23 after it. Investigations of patients of the first group were made at the time of 1 week to 6 years after trauma of the knee joint (the average meaning is 18 months). The second group was investigated at the time from 1,5 month to 5,5 years (the average meaning is 13 months).At the current research we did not find any specific for rupture of ACL functional disturbances during level walking compare to normal data and healthy limp. However, we assume some tendency to increase of flection-extention movement at the damaged knee joint after surgery.This result could give us some basis for revision the term of instability, because we did not get definite symptoms at our study.

The review analyzes the current advances of cell therapy for neurological complications of ischemic stroke and spinal cord injury (SCI). We demonstrate the most recent data on the use of different types of stem cells for the treatment of these severe damages, obtained both in experimental studies using animal models and in clinical studies. We particularly discuss the use of mesenchymal stem cells (MSC) and neural stem/progenitor cells (NSC/NPC) for the treatment of stroke and SCI. We also discuss the prospects for a further development of cell therapy of these diseases.

It is an acute problem for the 21st century to find effective and inexpensive methods for early detection of lung cancer. Patients, suspected of having a malignant disease of lungs, generally undergo clinical studies such as CT scans of the chest and bronchoscopy. The latter is mainly used to confirm the diagnosis. However, even when the signs, symptoms and radiological findings indicate that clinical diagnosis of malignant lung disease is evident, additional invasive procedures for obtaining the biological material suitable for the final confirmation of the presence of malignant cells are required. Currently, there is a clear understanding of the need to find biomarkers able to detect pre-clinical stage of cancer cells using minimally invasive procedures.

Primary cutaneous CD4+ small/medium T-cell lymphoma is very rare blood disease with usually good prognosis. However similar histology and immunohistоchemistry of this pathology with more aggressive T-cells lymphomas, such as mycosis fungoides, make it difficult for pathologist to find the accurate diagnosis. We report about of 40-year-old woman, whо came to our clinic with cheek skin lesion.