Vol 6, No 3 (2015)

Articles
30 let FNKTs FMBA Rossii
Khabazov R.I.
Abstract
Статья посвящена истории создания и развития 83-й клинической больницы ФМБА России (ныне - Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий ФМБА России) и приурочена к 30-летию учреждения.
Journal of Clinical Practice. 2015;6(3):3-8
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MEDICAL CARE TO PATIENTS WITH CARDIOVASCULAR DISEASE IN FEDERAL SCIENTIFIC CLINICAL CENTER
Chupin A.V., Staferov A.V., Zotov A.S.
Abstract
Diseases of the circulatory system are the major social problem worldwide. The prevalence of these diseases, disability, mortality, temporary disablement and the need for specialized medical care contribute to medical and social significance of this pathology, for which our society incurs tangible human and economic losses. According to experts, the number of deaths from CVDs will increase due to the increase of mortality among the male population from 18.1 million in 2010 to 24.2 million in 2030. Mortality rates from CVD in the Russian Federation - one of the highest in the world.
Journal of Clinical Practice. 2015;6(3):9-19
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SURGICAL CLINIC OF FEDERAL SCIENTIFIC CLINICAL CENTER FMBA OF RUSSIA: ON THE EDGE OF THE ACHIEVEMENTS OF MODERN SCIENCE AND PRACTICE
Panchenkov D.N., Ivanov Y.V.
Abstract
The article is devoted to the surgical clinic, Federal scientific clinical center FMBA of Russia, its modern level. Presented new surgical techniques successfully implemented over the last 5 years (2011-2015) and widely used in the surgical clinic of Federal scientific clinical center FMBA of Russia. Emphasis is placed on the description of new minimally invasive technologies. Given the ongoing attention of the clinic staff, research and educational work. The results of surgical clinic clearly show that the close and fruitful collaboration between practicing surgeons, the staff and specialists from other medical institutions, is fully justified.
Journal of Clinical Practice. 2015;6(3):20-29
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GAIT ANALYSIS AT PATIENTS WITH ANTERIOR CRUCIATE LIGAMENT RUPTURE BEFORE AND AFTER SURGICAL TREATMENT
Akhpashev A.A., Zagorodny N.V., Kaurkin S.N., Skvortsov D.V.
Abstract
The anterior cruciate ligament (ACL) is most often structures to be damaged. In this research investigated biomechanics of walking at the timing, kinematics and dynamics parameters for 34 patients which had verified rupture of ACL. The 11 patients were investigated before surgical treatment and 23 after it. Investigations of patients of the first group were made at the time of 1 week to 6 years after trauma of the knee joint (the average meaning is 18 months). The second group was investigated at the time from 1,5 month to 5,5 years (the average meaning is 13 months).At the current research we did not find any specific for rupture of ACL functional disturbances during level walking compare to normal data and healthy limp. However, we assume some tendency to increase of flection-extention movement at the damaged knee joint after surgery.This result could give us some basis for revision the term of instability, because we did not get definite symptoms at our study.
Journal of Clinical Practice. 2015;6(3):30-38
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MORPHOLOGICAL AND ULTRASOUND CHARACTERISTICS OF ENDOMETRIUM IN PATIENTS WITH BREAST CANCER AND THE RISK OF SECONDARY TUMORS
Gerasimov A.V., Krasilnikov S.E., Kedrova A.G., Afonina N.S., Nechaeva O.E., Maksimenko T.A., Kosyi V.V.
Abstract
The analysis of features of endometrial hyperplasia in patients with breast cancer (BC) receiving adjuvant tamoxifen therapy in the period from 2011 to 2014 inclusive. 196 patients with breast cancer with ultrasound criteria of endometrial hyperplasia were examined. A postoperative histopathologic examination revealed that the lesions were endometrial hyperplasias and with 4,1% malignant findings. Hyperplasia, polyps and endometrial cancer were diagnosed in patients receiving tamoxifen, which allowed a comparison clinicoanamnestic, ultrasound, morphological and genetic characteristics of the endometrium to recover a high risk of developing a second cancer, as well as offer a pathogenic variant of its prevention. The article can be interesting as for obstetrician-gynecologist, watching women after breast cancer treatment, and oncologists, choosing a drug for adjuvant therapy.
Journal of Clinical Practice. 2015;6(3):39-47
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CELL THERAPY OF STROKE AND SPINAL CORD INJURY COMPLICATIONS
Konoplyannikov M.A., Baklaushev V.P., Kalsin V.A., Tikhonovsky M.A., Averyanov A.V.
Abstract
The review analyzes the current advances of cell therapy for neurological complications of ischemic stroke and spinal cord injury (SCI). We demonstrate the most recent data on the use of different types of stem cells for the treatment of these severe damages, obtained both in experimental studies using animal models and in clinical studies. We particularly discuss the use of mesenchymal stem cells (MSC) and neural stem/progenitor cells (NSC/NPC) for the treatment of stroke and SCI. We also discuss the prospects for a further development of cell therapy of these diseases.
Journal of Clinical Practice. 2015;6(3):48-58
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CURRENT APPROACHES FOR THE DIAGNOSIS,RISK STRATIFICATION AND INTERVENTIONAL TREATMENT OF PATIENTS WITH ACUTE CORONARY SYNDROMES WITHOUT ST-SEGMENT ELEVATION
Ardashev A.V., Staferov A.V., Konev A.V., Afonina N.S., Negrun N.I., Himii O.V., Chelombitko E.G.
Abstract
This article reviews current approaches to diagnosis and determination of the individual risk of patients with acute coronary syndrome without ST-segment elevation. Guidelines for determining the choice of treatment strategy and the time slots for its implementation are discussed. We describe the technical features of the implementation of interventional treatment in this group of patients; the choice of methods of myocardial revascularization is discussed.
Journal of Clinical Practice. 2015;6(3):59-84
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MOLECULAR GENETIC APPROACHES IN THE DIAGNOSIS OF LUNG CANCER
Khodyrev D.S., Nikitin A.G., Kulagina N.S., Averyanov A.V.
Abstract
It is an acute problem for the 21st century to find effective and inexpensive methods for early detection of lung cancer. Patients, suspected of having a malignant disease of lungs, generally undergo clinical studies such as CT scans of the chest and bronchoscopy. The latter is mainly used to confirm the diagnosis. However, even when the signs, symptoms and radiological findings indicate that clinical diagnosis of malignant lung disease is evident, additional invasive procedures for obtaining the biological material suitable for the final confirmation of the presence of malignant cells are required. Currently, there is a clear understanding of the need to find biomarkers able to detect pre-clinical stage of cancer cells using minimally invasive procedures.
Journal of Clinical Practice. 2015;6(3):85-94
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INSUFFICIENCY OF PROPRIOCEPTIVE CONTROL AFTER PLASTIC OF THE ACL AS THE REASONFOR KNEE RE-INJURY IN PROFESSIONAL ATHLETES
Chekeres P.P., Budashkina M.V., Mukhanov V.V., Karpashevich A.A.
Abstract
Considered training regimes needed to restore both muscle strength of the operated limb and the neuromuscular balance of the lower extremities; and criteria for athlete returning to professional exercises, in the absence of which the risk of re-traumatisation of the knee joint is extremely high. The clinical example is given.
Journal of Clinical Practice. 2015;6(3):95-98
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A CASE OF RARE FORM OF PRIMARY CUTANEOUS CD4+ SMALL/MEDIUM T-CELL LYMPHOMA
Diakonov D.A., Fedorovskaya N.S., Luchinin A.S.
Abstract
Primary cutaneous CD4+ small/medium T-cell lymphoma is very rare blood disease with usually good prognosis. However similar histology and immunohistоchemistry of this pathology with more aggressive T-cells lymphomas, such as mycosis fungoides, make it difficult for pathologist to find the accurate diagnosis. We report about of 40-year-old woman, whо came to our clinic with cheek skin lesion.
Journal of Clinical Practice. 2015;6(3):99-102
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