Vol 21, No 2 (2013)

Articles
MORPHOGENESIS ABDOMINAL AORTIC ANEURYSM
Nikonenko T.N., Nikonenko A.A.
Abstract
This paper presents data on morphological changes in the wall of abdominal aortic aneurysms in order to study the importance of the inflammatory response in the development of an aneurysm. It is found that chronic inflammation plays a major role in the pathogenesis of abdominal aortic aneurysm formation. In the wall of the aneurysm revealed extensive inflammatory infiltrates of lymphocytes, macrophages, which are the main source of metalloproteinases that cause degeneration of elastin and collagen, which leads to the destruction of the wall structure and dilatation of the aorta.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):7-12
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MYC FAMILY GENES IN SOLID-PSEUDOPAPILLARY TUMORS OF THE PANCREAS
Gordienko E.N., Pakhlina O.V., Chekmareva I.A., Rothin D.L., Gorin D.S.
Abstract
In the paper the study of molecular disorder genes c-Myc and N-Myc in solid-pseudopapillary tumor of the pancreas. Examined 24 samples of tumors obtained from 21 patients, including 19 primary, recurrent 1, 4 metastasis. Fluorescence in situ hybridization was performed using DNA samples lokusspetsificheskih to the loci 2p24, 6q23, 8q24 company «Vysis, Abbott Laboratories Inc», demonstrated that amplification of the N-Myc gene in solid-pseudopapillary tumor can be another confirming its neurogenic origin.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):13-21
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MORPHOFUNCTIONAL CHARACTERISTICS OF THYROID GLAND OF MALE WISTAR RATS IN CASE OF PROLONGED ALCOHOL CONSUMPTION UNDER THE CONDITIONS OF VOLUNTARY INTAKE
Mkhitarov V.A., Makarova O.V.
Abstract
The aim of the work: the investigation of the morphofunctional features of the thyroid gland of male Wistar rats depending on the dose of consumed alcohol under the conditions of voluntary intake. The levels of thyrothrophin (TSH), triiodothyronine (T3), thyroxin (T4) and morphometric parameters of thyroid gland were estimated. Depending on the individual alcohol consumption three subgroups of rats were distinguished: with low (3,14±0,19 g/kg per day), medium (7,23±0,54 g/kg per day) and high consumption (13.51±1.12 g/kg per day). TSH concentration increased for the animals with medium and low consumption, being within normal limits for the animals with high consumption. The T4 level decreased in groups with medium and high consumption, T3 decreased only in the group with medium consumption. Under the conditions of voluntary intake alcohol induced an apparent activating effect onto the thyroid gland independently of the dose, which consisted in a mass increase and the increase of the nuclei area and thyrocyte height. The detected differences in rat alcohol consumption and the intensity of the activation signs of the thyroid gland under the conditions of voluntary intake can be stipulated by the genetically determined body properties.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):22-29
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THE CHITOSAN-COATED IMPLANTS WITH BIOACTIVE SURFACE DEMONSTRATE IMPROVED CHARACTERISTICS OF OSSEOINTEGRATION IN RATS
Novochadov V.V., Gaifullin N.M., Zalewski D.A., Semenov P.S., Shemonaev V.I.
Abstract
The application of chitosan on bioactive surface of the screw titanium implants was shown to improve the morphological characteristics of osseointegration after implantation into the rat femoral bone. The additional osteoconductive effect of the fine-dispersed chitosan appeared in more intensive and rapid osteogenesis around implants, and the more expressed remodeling and thickening of the surrounding trabecular bone.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):30-35
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CHANGES IN RAT THYMUS MORPHOLOGY AND FUNCTION AFTER CHRONIC EXPOSURE TO LOW DOSES OF DDT
Rodichenko E.P., Yaglova N.V., Yaglov V.V., Obernikhin S.S.
Abstract
There is increasing evidence that chronic environmental exposure to DDT and other pesticides play an important role in disregulation of the immune system and increased incidence of autoimmune and allergic diseases. The aim of the research was to investigate whether consumption of low doses of DDT may affect the immune system and change morphology and function of thymus. The research was performed on 42 Wistar rats 80-100gg body weight. Rats were exposed to 1.89±0.086μg/kg DDT per os for 6 and 10 weeks. Histological examination found time-depending acceleration of apoptosis both of lymphocytes and reticuloepitelial cells. After 10 weeks of exposure proliferation of thymocytes was significantly decreased. Concanavalin A-induced mitogenic activity of thymocytes after 10 weeks of exposure to DDT was 6 times higher than the control values. The data obtained showed that even low doses of DDT accelerated thymus aging and modulated proliferation of thymocytes.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):36-42
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PASSIVE AVOIDANCE BEHAVIOR AFTER STRESS EXPOSURE OF RATS IMMUNIZED BY GLUTAMATE-BSA CONJUGATE
Umryukhin A.E., Chekmareva N.Y., Sotnikov S.V., Vetrile L.A., Zaharova I.A.
Abstract
Behavior of rats in passive avoidance task was studied after their immunization by glutamate-BSA conjugate. Active rats immunized by conjugate displayed decreased avoidance of aversive stimuli when tested after stress exposure. It may be concluded that immunization by glutamate conjugate is accompanied in active rats by reorganization of avoidance behavior after stress.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):43-48
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DYNAMICS OF ADAPTIVE MECHANISMS SUCH AS THE OPTIMIZATION CRITERIA MAGNETIC INTERFERENCE
Bulatetsky S.V., Byalovsky Y.Y., Glushkova E.P.
Abstract
This article has studied the local action of the alternating magnetic field on the nonspecific mechanisms of human adaptation. It is shown that the body’s response to the electromagnetic effect is a complex phenomenon system, including mechanisms at various levels and has its own functional organization. Parameters of local influences AMF must be optimized based on the dynamics of adaptive mechanisms: the spatio-temporal local magnetic therapy must maintain a minimum activation of stress mechanisms and implement the most include stress-limiting mechanisms.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):49-53
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MEDICO-SOCIAL ASPECTS OF POSTPARTUM PURULENT-SEPTIC COMPLICATIONS
Chernov A.V., Brigadirova V.Y., Korotkih I.N.
Abstract
On the basis of retrospective study the risk factors are identified, which commonly found among women with postpartum purulent-septic complications, and with using of nonparametric measures make analysis of their significance.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):54-58
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TO THE MECHANISM OF ACTION OF NEW ANTIHYPOXIC COMPLEX COMPOUND OF ASCORBIC ACID
Novikov V.E., Markova E.O., Parfenov E.A.
Abstract
In the experiment on rats a new derivative of ascorbic acid with antihypoxic activity was learned. It is shown that a dose of 100 mg / kg in normoxia and after exposure to acute hypoxia, it reduces the activity of free radical oxidation, has no effect on the hemogram, but leads to a significant reduction of ALT, AST, alkaline phosphatase, LDG, the level of uric acid and total protein after acute hypoxia, which is of some importance in its hypoxic effect.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):59-65
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STUDYING OF ANTIATHEROGENEOUS PROPERTIES OF PREPARATIONS FROM THE BIOMASS OF GINSENG AND POLISCIAS FILICIFOLIA BAILET CELLULAR CULTURE
Ryabkov A.N., Slepnev A.A.
Abstract
This article is devoted to an assessment of degree of expressiveness of antiatherogenous properties of preparations from the biomass of ginseng and poliscias filicifolia bailey cellular culture. The experiments were performed on rabbits, kept for a month on the strictly antioksidantless diet and on the hypodynamy immobilization condition. An analysis of the biochemical parameters of serum lipid spectrum and intensity of lipid peroxidation in the tissue of the aorta in preventive and therapeutic uses of comparable compaunds indicates a rather pronounced antiatherogenic properties of drugs of Araliaceae plant biomass, especially poliscias fiicifolia.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):66-70
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HYGIENIC AND EPIDEMIOLOGICAL ASPECTS OF THE WORK OF MODERN OBSTETRIC FACILITIES
Kiriushin V.A., Kotelevets E.P.
Abstract
The main indicators of the quality of the art medical facilities are the lack of infections associated with medical care (IHS) for patients and staff, low level of occupational diseases. These indicators can provide only a set of preventive measures aimed at improving the quality of patient care and safety of personnel.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):71-78
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DYNAMICS AND TRENDS REPRODUCTIVE LOSSES IN THE RYAZAN REGION
Medvedeva O.V., Petrova E.I.
Abstract
The paper presents an analysis of reproductive losses, which, in addition to part of the reproductive potential and reproductive behavior, is one of the most important characteristics of reproductive health. The main directions of improving reproductive health can only be realized by improving the quality of basic obstetric and perinatal care.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):79-81
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SOME ASPECTS OF RHEUMATIC HEART DISEASE PROBLEM
Petrov V.S.
Abstract
The fifth years condition of patient with rheumatic heart disease, change in quality of life, echocardiographic data and chronic heart failure progress present in article. The patients had not change in chronic heart failure condition and quality of life but had negative echocardiographic dynamic. Combination of atrial fibrillation, diabetes mellitus, severe mitral stenosis and left atrial dilatation increase risk of death patients with rheumatic heart disease.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):82-87
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METABOLIC SYNDROME IN THE PRACTICE OF THE THERAPIST CITY POLYCLINIC: EXPERIENCE OF DIETARY THERAPY JAM OF LAMINARIA, ENRICHED WITH CHROMIUM, AND METFORMIN
Dashkevich O.V., Nizov A.A., Lapkin M.M., Trutneva E.A., Gershunskaya V.V.
Abstract
We investigated safety and efficacy of metformin and dietary product - jam laminaria, enriched with chromium, in integrated ambulatory treatment of patients with metabolic syndrome (MS). During the 6 months we observed 81 patients with MS, the average age of 50, 3 ± 1, 9 years old, who were divided into 3 comparable groups. Patients of the comparison group (n=30) with recommendations on modeling lifestyle and drug therapy of diseases; the first group of patients (n=31) was additionally appointed with metformin 1500-2000 mg/day, and patients in the second group (n=20) received dietary product 20 g/day. Surveillance in all groups of patients registered reduction of overweight, improved clinical and laboratory parameters, adaptive organism reserves and quality of life. The use of metformin and the dietary product in treatment of MS allowed to achieve a more pronounced positive dynamics in patients than in the comparison group.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):88-92
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PROINFLAMMATORY CYTOKINES AND THEIR ROLE IN THE DEVELOPMENT OF CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH HYPOTHYROIDISM
Vernigorodsky V.S., Fetisova N.M., Vernigorodskaya M.V.
Abstract
The study of interleukin-6 and C-reactive protein in 101 patients with hypothyroidism revealed a close relationship between metabolic, proinflammatory factors and the state of blood vessels in patients with hypothyroidism (p <0,05) compared to healthy individuals. Formation of pro-inflammatory state is a risk factor for vascular intimal lesions in patients with hypothyroidism, especially with the idiopathic form of it.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):93-96
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HYPOTHYROIDISM AND PREGNANCY
Titova L.Y., Aristarkhov V.G., Puzin D.A.
Abstract
The functional status of the thyroid gland (TG). Inpregnant women with a hypothyroidism. Using laser therapy treatment with thyroid contributes to lowering titer antibodies to TPO and the quality of TSH.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):97-101
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THE COMPARATIVE CHARACTERISTIC OF NEUROPSYCHOPHYSIOLOGICAL STATUS OF PATIENTS WITH MULTIPLE SCLEROSIS AND PARKINSON’S DISEASE
Lorina L.V., Butova V.M., Dzhaparalieva N.T.
Abstract
The role of а-motor neurons in the pathogenesis of spasticity and rigidity in multiple sclerosis and Parkinson’s disease. Extent of change in motor unit potentials (MUP) in multiple sclerosis and Parkinson’s disease is directly dependent on the shape and duration of the disease. Quality of life, health-related, in patients with multiple sclerosis suffer less than in patients with Parkinson’s disease. All patients perceive their disease as a stressful factor reduces the quality of life and limits their role in society.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):102-106
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ANALYSIS OF ANTERIOR RESECTION OF THE RECTUM RESULTS
Semionkin E.I., Khubezov D.A., Kulikov E.P., Trushin S.N., Ogoreltsev A.Y., Lukanin R.V., Yudina E.A.
Abstract
The analysis of treatment of 154 patients with rectal cancer after resection of the rectum in specialized department was done. Safety of machine stitch in rectal cancer surgery and reasonability of preventive colostomy especially in low rectal cancer localization were showed.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):107-110
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SURGICAL TREATMENT OF MORBID OBESITY
Yudin V.A., Usachev I.A., Melnikov A.A.
Abstract
The paper presents the material with the problems of surgical treatment of patients with severe obesity. On a sufficient factual material provides an assessment of all the authors of the applied methods of bariatric operations, dynamics of decrease in weight. Attention is drawn to the causality of the development of complications and methods of their treatment. Estimated remote (over three years) the results of operations.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):111-118
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INFLUENCE FACTORS SPECIFIC TO MILITARY SERVICE PERFORMANCE COMPONENT OF THE BODY MASS YOUTH
Shpakova N.A., Andriychuk V.M., Guminskiy Y.I.
Abstract
Identification of the possible impact of specific factors on the military service component composition of body weight in a population of healthy young men serving in the armed forces.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):119-123
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THE LOWER LIMB FUNCTIONAL STATE IN PATIENTS WITH THE KNEE INTRA-ARTICULAR FRACTURES AFTER TREATMENT USING THE ILIZAROV FIXATOR COMBINED WITH ARTHROSCOPY
Dolganova T.I., Sizova T.V., Karasev E.A., Karaseva T.Y., Karasev A.G.
Abstract
The results of treatment using the Ilizarov fixator combined with arthroscopy in 39 patients (38±4.5 years) with the knee intra-articular fractures have been analyzed clinically and physiologically. The functional state of the lower limb muscles has been evaluated depending on the type of feet support responses using the techniques of dynamometry and electromyography. Significant changes in the stride cycle parameters were registered in case of > 40% asymmetry of the moment of force values of leg flexors/extensors and < 1.0 values of the index of antagonist muscles. When the antagonist index was < 0.5 the ability to maintain the body stable balance in walking was disordered, and the patients had to use additional supports. Attention should be primarily focused to the recovery of the anterior group of femoral muscles in patients with Type I feet support responses, and to that of both the anterior and posterior groups of femoral muscles - for patients with Type II. Treatment-and-rehabilitation measures should be directed to the function recovery of femoral and leg muscle groups for Type III of feet support responses.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):124-129
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ROLE OF PROINFLAMMATORY CYTOKINES IN CHRONIC HEART FAILURE
Osipova O.A., Suyazova S.B., Vlasenko M.A., Godlevskaya O.M.
Abstract
Accumulating evidence indicates that cytokines play an important role in the pathogenesis of chronic heart failure. The review considers the participation of proinflammatory cytokines (factors-necroses-tumors-α, interleukin 1β and interleukin 6) in the pathophysiological processes of congestive heart failure, as well as the influence of proinflammatory cytokines on cardiac contractility, hypertrophy and remodeling of the left ventricle of the heart, apoptotic, and fibrotic processes.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):130-135
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ROLE OF MATRIX METALLOPROTEINASES IN THE PATHOGENESIS OF PRIMARY OPEN-ANGLE GLAUCOMA
Sokolov V.A., Levanova O.N.
Abstract
Matrix metalloproteinases (MMPs) - a family of enzymes, which convert extracellular matrix. Proved the role of MMPs in apoptosis of retinal ganglion cells, tissues remodulition the optic nerve and the change in the form of lattice plate with POAG. MMPs are involved in violations of blood aqueous barrier and the regulation of intraocular fluid. Many papers have focused on the role of these enzymes in the filter pad with scarring antiglaucomatous operations. The study of MMPs offers the prospect of early diagnosis and targeted therapy of POAG pathogenesis.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):136-141
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PECULIARITIES OF TREATMENT AND PROPHYLAXIS OF INITIAL CARIES AND CHRONIC CATARRHAL GINGIVITIS
Galizina O.A.
Abstract
The article is devoted to the review of the modern literary data regarding peculiarities of treatment and prophylaxis of initial caries and chronic catarrhal gingivitis use phyto medicines. The role of microorganisms in appearance and progression of caries and diseases of marginal periodont is described in article. Usage of medicines on the base of plants is the most perspective trend in prophylactic medicine nowadays. Phyto medicines cause bactericide, anti-inflammatary, analgetic, reparative actions combined with absence of disadvantages.
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):142-148
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RETsENZIYa na monografiyu D.F. Khritinina, D.S. Petrova, O.E. Konovalova «Organizatsiya lecheniya i reabilitatsii bol'nykh shizofreniey na osnove semeyno-orientirovannogo podkhoda»
Semke V.Y.
Abstract
I.P. Pavlov Russian Medical Biological Herald. 2013;21(2):149-150
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