Vol 25, No 4 (2014)

Despite the fact that obesity is regarded as a risk factor of a number of chronic diseases, the world is accumulating ambiguous information on the association between obesity and survival.

Liposuction is the simplest method that allows a sufficient number of mesenchymal stem cells (MSCs) to be obtained for regenerative purposes. Water-jet technology retains a high percentage of viable MSCs and adipocytes.

The paper considers the negative sequels of glucosotoxicity, lipotoxicity, and glucolipotoxicity in patients with type 2 diabetes mellitus in the presence of visceral obesity and outlines the ways of correcting these metabolic disturbances.

Trimetazidine used in patients with coronary heart disease during coronary bypass surgery under extracorporeal circulation and pharmacological cold cardioplegia provides an additional cardioprotective effect.

Gastroduodenal peptic ulcer is one of the most common digestive diseases. Despite the multietiological pattern of the disease, Helicobacter pylori infection remains its leading etiological factor and proton pump inhibitors form a basis for the therapy. The use of timely diagnostic methods and the choice of rational management tactics will be able to reduce therapy costs and to improve quality of life.

Hereditary sensory and autonomic polyneuropathies (HSAP) is a group of rare inherited diseases with progressively decreased sensitivity, leading to insensibility to pain. A case of mutating HSAP is described. The specific feature of the case is the absence of pain syndrome. The given clinical example suggests that there is a need to increase awareness of the clinical picture of HSAP and the ways of early detection of patients with such disabling hereditary polyneuropathies among physicians of different specialties.

The paper describes a clinical case of severe cognitive impairments in an elderly female patient with uncompensated hypothyroidism.

Latent HBV infection characterized by the isolated location of viral DNA in the liver in the absence of HBEe-, HBs-antigenemia and viremia was identified in 40,8% of patients with chronic viral hepatitis B (CVHB) in the presence of IgG class antibodies to nuclear HBV protein. CVHB with latent infection showed a weak activity and low-symptom benign course in 69,4% of the patients; but in 12,2% hepatocytic inflammation and fibrosis continuously progressed and liver cirrhosis developed 15-20 years later.

A randomized double-blind placebo-controlled trial of the medical and economic efficiency of magnetic therapy for gonarthrosis has been first conducted in the Russian Federation. There is evidence for the expediency of its incorporation into a medical intervention.

The paper presents the results of a systems analysis of the data available on the clinical and experimental pharmacology of drugs based on human placental extracts.

The paper discusses the impact of metabolic syndrome, including its manifestations, such as hyperaldosteronism, on the pathogenesis of neuroleptic cardiomyopathy.

Modified low-density lipoproteins (LDL) stimulate cholesterol accumulation in the cells of blood vessels, favoring the development of atherosclerosis. The enzyme trans-sialidase induces atherogenic modification of LDL. This investigation has studied the effect of extracts from natural products on plasma trans-sialidase activity.

The results of a comprehensive study were used to formulate the basic principles in the setting of work quotas for physicians in the system of controlling their motivation process to increase the availability of ambulatory health care at an urban polyclinic.