Vol 68, No 5 (2019)

Based on the analysis of legal issues and documentation in the field of statutory regulation of the circulation of medicines and cosmetics, the authors provide an overview of the procedure for registration of medicines and cosmetics in the Russian Federation, the European Union, and the USA. The procedure for registration of Russian and imported medicines, as well as cosmetics in the Russian Federation and foreign countries is provided at the federal level and has a number of substantial differences, the purpose of which is to obtain information on the efficacy and safety of a product.

Telogen hair loss is a common type of alopecia. It is characterized by a sudden onset and can occur in both women and men at any age. Factors that can provoke both acute and chronic telogen hair loss, as well as drugs used in its therapy are considered. Exogenous (drugs and various chemicals) and endogenous (infectious diseases) intoxications play a substantial role in the development of this disease. Drug therapy for telogen hair shedding is based on the correction of nutrient, vitamin, and mineral deficiencies. The vitamin and mineral complexes prescribed should contain protein, essential fatty acids, zinc, selenium, copper, vitamin C, biotin, vitamins B, L-cysteine, if necessary, iron, copper, and folic acid. The patients with telogen hair loss may have a favorable prognosis when the causal factors are eliminated.

Introduction. Yellow iris (Iris pseudacorus L.) is widespread in the Russian Federation. The plant has a complex multicomponent composition of biologically active substances. However, the use of yellow iris rhizomes is very limited in Russian officinal medicine. The wider use of yellow iris rhizomes as a pharmaceutical plant substance and the design of innovative drugs require regulatory documentation that meets the current requirements for medicinal plant raw materials. Objective: to conduct in-depth morphological and anatomical studies of yellow iris rhizomes for the subsequent development of the draft pharmacopoeia article (PA) «Yellow iris rhizomes» Material and methods. The dried yellow iris rhizomes stored in the Shatura District, Moscow Region, in the summer of 2015 were investigated. The appearance and anatomical structure of the rhizomes were analyzed using the methods laid down in the State Pharmacopoeia of the Russian Federation, 14th edition (SP 14). Results. The investigators provide a refined and extended description of the appearance of yellow iris rhizomes of different processing forms (the rhizomes can be left whole, grounded, or powdered). Microscopic analysis made it possible to clarify their diagnostic signs characterizing whole raw materials and to visualize them. Conclusion. The findings of the in-depth morphological and anatomical studies of yellow iris rhizomes, which revealed their diagnostic signs, can be used in the development of a draft PA for raw materials.

The provision of the Russian Army and Navy with medical chests which were a specially selected and systematized range of medical products, packaged in a specific container was initiated in the Petrine era. It is established that numerous wars and armed conflicts, as well as the development of medicine became a powerful boost to improve the equipping of military medical units and military hospitals. It is shown that the scientists and specialists of the Military Medical Academy, the Scientific Research Sanitary Institute of the Red Army, and the Main Military Medical Administration made a weighty contribution to the development of medical chests and substantiated their configuration and content, which contributed to the better medical support of the Armed Forces.

Introduction. Organic molecules belonging to the class of amidines have a broad spectrum of biological activity: antimicrobial, anticoagulant, anti-inflammatory, analgesic, etc. But these compounds are poorly soluble in water and in most organic solvents, which is a substantial disadvantage in designing new pharmaceuticals based on them. The introduction of the substituents into the molecules of these compounds, which fail to alter the biological activity and toxicity, but change the solubility, or the obtaining of salts with a higher solubility, is one of the ways to solve this problem. Objective: to investigate the biological activity of synthesized N-arylbenzamidines and their hydrochlorides. Material and methods. N-arylbenzamidines were obtained by baking arylamines with benzonitrile in the presence of aluminum chloride. N-arylbenzamidine hydrochlorides were synthesized by passing dry hydrogen chloride through a suspension of N-arylbenzamidines. Acute toxicity was determined by the Miller-Teichner method. Anti-inflammatory activity was studied using the formalin-induced rat paw edema method. For experimental evaluation of analgesic activity, an acetic acid-induced writhing model was used in male mice. Antimicrobial activity was investigated by the serial dilution method. Results. Series of N-arylbenzamidines and their hydrochlorides were synthesized. The structure of the compounds obtained was proved using modern methods of analysis. The synthesized compounds were studied in terms of acute toxicity and biological (antimicrobial, analgesic and anti-inflammatory) activity. Conclusion. The acute toxicity of the obtained N-arylbenzamidines and their salts depends on the electronic nature of the substituent in the aryl moiety. Increasing the electron-acceptor nature of the substituent reduces the toxicity of synthesized compounds. N-arylbenzamidines, unlike their hydrochlorides, have pronounced antimicrobial, anti-inflammatory, and analgesic activities. These properties are at the level of widely used antimicrobial drugs, such as fluoroquinolones and chlorhexidine. The presence of an electron-acceptor substituent in the aryl moiety of amidines leads to an increase in antimicrobial activity.