Vol 70, No 5 (2021)

The paper presents a review, generalization and systematization of literature data on the main plant sources of polyprenols, the methods of their preparation and standardization, biosynthesis, metabolism, a biological role, pharmacodynamic effects, mechanisms of action, and areas of therapeutic use of polyprenols. Polyprenols are an original class of natural compounds, namely: a group of long-chain isoprenoid alcohols, in which 2,3-dihydro derivatives, dolichols, are natural bioregulators. Dolichols are formed in the liver and are directly involved in the synthesis of cell membrane glycoproteins, being oligosaccharide donors in the process of N-glycosylation of proteins, which determines one of the mechanisms of their pharmacological action: the process of cell regeneration and renewal is accelerated. When entering the human body, natural polyprenols normalize natural cell needs for endogenous dolichol phosphate, promoting the intensification of glycoprotein biosynthesis. The most obvious mechanism of action of polyprenols, dolichols in particular, is the suppression of oxidative stress: due to their chemical structure, dolichols has been found to act as fat-soluble antioxidants. In addition, polyprenols are noted to be able to increase the fluidity and permeability of biological membranes, which favors the stimulation of metabolic processes and the increase of cell viability. The properties of polyprenols predetermine their wide spectrum of pharmacological action. The main sources of polyprenols are coniferous plants (various types of fir (Picea), silver fir (Abies), and pine (Pinus)), as well as maidenhair tree (Ginkgo biloba L.). At the same time, a long-chain polyprenol mixture isolated from the leaves of maidenhair tree is dominated by polyprenols that are similar in the number of isoprene units to that of mammalian dolichols. Polyprenols have a significant, not fully evaluated therapeutic potential, which is the initiating factor in the in-depth study of their pharmacological properties.

Introduction. The study of consumer behavior when choosing the necessary product is aimed at identifying and analyzing the factors that influence the purchasing decision. The findings allow medical and pharmacy practitioners to meet the needs of patients, including those with myocardial infarction (MI), for the necessary medicines in the process of pharmaceutical care. The denoted category of consumers in the country's healthcare system is particularly important in both medical and social contexts. Objective: to analyze needs and preferences in the consumers of medical and pharmaceutical goods and services in the system of pharmaceutical assistance to the population with MI. Material and methods. Data from a questionnaire-based survey of 416 patients with MI were used as primary documentation in the study. Respondents were selected from a random non-repeated sample. The concepts of the questionnaire blocks for studying the needs and preferences in the consumers of medical and pharmaceutical goods and services were considered as a studied phenomenon, which make it possible to identify the patterns of consumer behavior of the population with MI and can serve as a basis for optimizing medical and pharmaceutical care. The material was processed using the Statistica 10.0 program. Results. The needs and preferences of the population with MI, who are consumers of medical and pharmaceutical services, were studied. The sociodemographic characteristics of the members of reference groups were compiled. Data on their health status, medical and pharmaceutical culture were collected. The awareness about preferences in medical and pharmaceutical services, patients' adherence to medical recommendations, and preferences of medical and pharmaceutical services was explored. Conclusion. The performed studies confirm the need for a detailed assessment of customer satisfaction in the treatment of MI. On its basis, it is possible to more effectively form loyal or regular customers, which requires pharmacies to constantly meet consumer preferences and to ensure an improvement in the quality of medical and pharmaceutical care to the population.

Actuality: In this timethere are many different topical medicines inducing wound healing. Many drug forms or their active substances are produced abroad. Active substance selenopyrane with antioxidant, immunomodulatory and other actions was synthesized by research center “Park of activemolecules” (Obninsk). Topical action of substance has not been researched. Research purpose: study of wound healing activity of gel-cream, containing 1% selenopyraneon a model of a full-thickness planar wound in rats. Material and methods: wound healing activity of gel-cream, containing 1% selenopyrane has researched on model of a fullthickness planar wound in rats. Animals were divided into 3 groups: I - intact group; II - group of rats, were treated by gel-cream with selenopyrane; III - group of rats, were treated by dexpanthenol cream (comparison drug). Histological preparations of skin from wound area were made after the end of research (day 14). Results: On the 3rd day of experiment relative wound area in animal treated by selenopyrane was 2.1 % less than in intact rats but differences were not statistically significant. On the 5th day of experiment there was statistically significant difference of relative wound area in II group of animals in comparison with I (intact) group: 45.8% and 64.6% accordingly. Thus, gel-cream containing 1% selenopyran accelerated the onset of the wound process second phase- proliferation phase. Histological research showed that gel-cream containing of 1% selenopyran stimulates the epithelization of the wound defect of the skin with epidermis layers differentiation.