On the issue of standardization of wild chicory grass

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Introduction. Expansion of the nomenclature of medicinal plant raw materials for creation of effective medicines on their basis is one of the priority directions of pharmaceutical science. Among representatives of the native flora, common chicory is of interest for study.

Objective: This article is devoted to the study of chicory herb proposed as a raw material for the production of medicines.

Results. As a result of pharmacognostic study of chicory herb samples, authenticity criteria (morphological and anatomical signs, thin layer chromatography) and quality indicators have been established. On the basis of the analysis of experimental batches of raw materials the norms of numerical indicators have been determined. A method of quantitative determination of the content of active substances has been developed.

Conclusion. The proposed quality criteria are included in the draft pharmacopoeial article on a new type of medicinal plant raw material Chicory herba.

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作者简介

Olga Saybel

All-Russian Research Institute of Medicinal and Aromatic Plants

编辑信件的主要联系方式.
Email: olster@mail.ru
ORCID iD: 0000-0001-8059-5064

Doctor of Pharmaceutical Sciences, Head of the Center for Chemistry and Pharmaceutical Technology, All-Russian Research Institute of Medicinal and Aromatic Plants

俄罗斯联邦, Grina str., 7/2, Moscow, 117216

Elena Konyaeva

All-Russian Research Institute of Medicinal and Aromatic Plants

Email: lencon64@mail.ru
ORCID iD: 0000-0002-2154-3755

Senior Researcher at the Department of Chemistry of Natural Compounds, All-Russian Research Institute of Medicinal and Aromatic Plants

俄罗斯联邦, Grina str., 7/2, Moscow, 117216

Andrey Radimich

All-Russian Research Institute of Medicinal and Aromatic Plants

Email: vilarnii.radimich@mail.ru
ORCID iD: 0000-0002-1139-8902

Senior Researcher at the Department of Chemistry of Natural Compounds, All-Russian Research Institute of Medicinal and Aromatic Plants

俄罗斯联邦, Grina str., 7/2, Moscow, 117216

Tamara Rendyuk

Sechenov First Moscow State Medical University (Sechenov University)

Email: rendyuk_t_d@staff.sechenov.ru
ORCID iD: 0000-0002-0359-3847

PhD of Pharmaceutical Sciences, Associate Professor, Department of Pharmaceutical Natural Sciences, Institute of Pharmacy, Sechenov University

俄罗斯联邦, Trubetskaya str., 8/2, Mosсow, 119991

Tamara Dargaeva

All-Russian Research Institute of Medicinal and Aromatic Plants

Email: vilarnii@mail.ru
ORCID iD: 0000-0002-0722-9479

Doctor of Pharmaceutical Sciences, Professor, Chief Researcher at the Department of Chemistry of Natural Compounds, All-Russian Research Institute of Medicinal and Aromatic Plants

俄罗斯联邦, Grina str., 7/2, Moscow, 117216

参考

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  14. Lupanova I.A., Ferubko E.V., Saibel O.L., Kurmanova E.N., Nikolaev S.M. Experimental study of anti-inflammatory properties of the extract of herb extract of wild-growing chicory (Cichorium intybus L.). Proceedings of the International Scientific Conference "From plant to drug". Moscow, 2021; 563–7 (in Russian).
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2. Fig. 1. Diagnostic features of the anatomical structure of the herb of wild-growing common chicory: 1 – lower epidermis of leaf (×400), 2 – simple multicellular multi-row hairs (×200), 3 – simple multicellular multi-row hair with collapsed cell walls (×200), 4 – hair fragment (×200), 5 – place of hair attachment (×200), 6 – stem epidermis (×400), 7 – glandular hair (×200), 8 – places of hair attachment (×200), 9 – fragments of wrapper leaflet with simple hairs (apex and margin of denticle): a – filiform, б – cone-shaped, в – papilla-like outgrowths (×200), 10 – glandular hairs (×200), 11, 12 – fragments of uvular flower with simple and cephalic hairs (11 – ×200, 12 – ×400), 13 – pollen (×400).

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3. Fig. 2. TLC chromatogram of Merk Kieselgel 60 (365 nm): before treatment (а) and after treatment (б) with 1% alcoholic solution of diphenylboronic acid aminoethyl ether (1 – alcoholic extract from common chicory herb, 2 – CO of chicory acid, 3 – CO of esculentine).

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4. Fig. 3. UV-visible spectra of alcoholic extract from common chicory herb (1) and CO solution of chicoric acid (2)

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