Email this article Experience of successful treatment of a patient with chronic non-bacterial osteomyelitis (clinical case)
- Authors: Tairov G.N.1, Toptygina A.P.2, Ochkurenko A.A.1, Buklemishev Y.V.1, Karpov I.N.1
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Affiliations:
- Priorov National Medical Research Center of Traumatology and Orthopedics
- G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology
- Issue: Vol 29, No 4 (2022)
- Pages: 403-411
- Section: Clinical case reports
- URL: https://journals.eco-vector.com/0869-8678/article/view/111823
- DOI: https://doi.org/10.17816/vto111823
- ID: 111823
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Abstract
BACKGROUND: Chronic nonbacterial osteomyelitis is a rare autoinflammatory bone disease with periods of relapses and remissions. No etiotropic therapy, diagnostic and treatment standards exist, patients are observed by rheumatologists, immunologists, and orthopedist. They receive symptomatic, anti-inflammatory treatment, broad-spectrum antibiotics, immunosuppressants to control inflammation, which helps to prevent new or to reduce existing pathological foci.
CLINICAL CASE DESCRIPTION: This article describes the effect of immune therapy and osteotropic treatment with zoledronic acid combination in a patient with chronic non-bacterial osteomyelitis. In a clinical observation involving comprehensive examination, including radiological (radiography, computed tomography and magnetic resonance imaging) and laboratory methods, a positive outcome was achieved using conservative methods of treatment in a patient with chronic non-bacterial sternum osteomyelitis.
CONCLUSION: Thus, a combination of bisphosphonates and immunotherapy may be promising in the treatment of chronic non-bacterial osteomyelitis. However, it is unknown as to how long the remission will last and what treatment program is necessary for the final disease resolution.
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About the authors
Gazinur N. Tairov
Priorov National Medical Research Center of Traumatology and Orthopedics
Author for correspondence.
Email: Gazinur.vezunchik@mail.ru
Post-Graduate Student, Traumatologist-Orthopedist
Russian Federation, MoscowAnna P. Toptygina
G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology
Email: toptyginaanna@rambler.ru
ORCID iD: 0000-0002-9981-4762
SPIN-code: 8523-5018
MD, Dr. Sci. (Med.), Immunologist-Allergologist, Head of the Laboratory of Cytokines
Russian Federation, MoscowAlexander A. Ochkurenko
Priorov National Medical Research Center of Traumatology and Orthopedics
Email: cito-omo@mail.ru
ORCID iD: 0000-0002-1078-9725
SPIN-code: 8324-2383
MD, Dr. Sci. (Med.), Professor, Traumatologist-Orthopedist
Russian Federation, MoscowYuriy V. Buklemishev
Priorov National Medical Research Center of Traumatology and Orthopedics
Email: buklemishev@mail.ru
ORCID iD: 0000-0002-0039-2118
SPIN-code: 4329-4720
MD, Traumatologist-Orthopedist
Russian Federation, MoscowIgor N. Karpov
Priorov National Medical Research Center of Traumatology and Orthopedics
Email: igoukarpoff@mail.ru
ORCID iD: 0000-0002-3135-9361
SPIN-code: 5943-3689
MD, Cand. Sci. (Med.), Radiologist
Russian Federation, MoscowReferences
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).